Tchem RBBP9 Putative hydrolase RBBP9

Protein Summary

Description

May play a role in the transformation process due to its capacity to confer resistance to the growth-inhibitory effects of TGF-beta1 through interaction with retinoblastoma and the subsequent displacement of E2F-1. The protein encoded by this gene is a retinoblastoma binding protein that may play a role in the regulation of cell proliferation and differentiation. Two alternatively spliced transcript variants of this gene with identical predicted protein products have been reported, one of which is a nonsense-mediated decay candidate. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O75884
• D3DW31
• Q5JPH9
• Q9H1D8

Gene Name

• RBBP9

Ensembl ID

• ENST00000337227
• ENSP00000336866
• ENSG00000089050

Symbol

• BOG
• RBBP10
• BOG
• RBBP10

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cellular component	0.85
virus perturbation	0.83
tissue	0.61
transcription factor perturbation	0.61
cell line	0.57

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.36   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 270   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.36   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 270   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0