You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
RBBP9
Putative hydrolase RBBP9

Protein Summary
Description
May play a role in the transformation process due to its capacity to confer resistance to the growth-inhibitory effects of TGF-beta1 through interaction with retinoblastoma and the subsequent displacement of E2F-1. The protein encoded by this gene is a retinoblastoma binding protein that may play a role in the regulation of cell proliferation and differentiation. Two alternatively spliced transcript variants of this gene with identical predicted protein products have been reported, one of which is a nonsense-mediated decay candidate. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000337227
  • ENSP00000336866
  • ENSG00000089050

Symbol
  • BOG
  • RBBP10
  • BOG
  • RBBP10
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.85
virus perturbation
0.83
tissue
0.61
transcription factor perturbation
0.61
cell line
0.57


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.83   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 270   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.83   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 270   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RB binding protein 9, serine hydrolase
VGNC:14288
458118
Macaque
RB binding protein 9, serine hydrolase
698192
Mouse
MGI:1347074
26450
Rat
RGD:3542
29459
Dog
RB binding protein 9, serine hydrolase
VGNC:45396
607819
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RB binding protein 9, serine hydrolase
Macaque
RB binding protein 9, serine hydrolase
Mouse
Rat
Dog
RB binding protein 9, serine hydrolase
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O75884-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (4)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (38)
1 – 10 of 38
YRDC
Tdark
Novelty: 0.01240103
Score: 0.935
Data Source: STRINGDB
POLR3F
Tbio
Family: Enzyme
Novelty: 0.0805125
Score: 0.776
Data Source: STRINGDB
DTD1
Tbio
Family: Enzyme
Novelty: 0.11544469
Score: 0.732
Data Source: STRINGDB
KAT14
Tbio
Novelty: 0.17168043
Score: 0.73
Data Source: STRINGDB
DZANK1
Tdark
Novelty: 1.1964364
Score: 0.728
Data Source: STRINGDB
PPME1
Tchem
Family: Enzyme
Novelty: 0.01559862
Score: 0.682
Data Source: STRINGDB
RSC1A1
Tbio
Novelty: 0.23664927
Score: 0.64
Data Source: STRINGDB
ABHD18
Tdark
Novelty: 10.43528841
Score: 0.622
Data Source: STRINGDB
LYPLA2
Tchem
Family: Enzyme
Novelty: 0.05436006
Score: 0.589
Data Source: STRINGDB
ZNF133
Tbio
Family: TF
Novelty: 0.20117958
Score: 0.587
Data Source: STRINGDB
Publication Statistics
PubMed Score  13.83

PubMed score by year
PubTator Score  19.85

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer