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Tbio
CYP7B1
25-hydroxycholesterol 7-alpha-hydroxylase

Protein Summary
Description
Oxysterol 7alpha-hydroxylase that mediates formation of 7-alpha,25-dihydroxycholesterol (7-alpha,25-OHC) from 25-hydroxycholesterol (PubMed:10588945). Plays a key role in cell positioning and movement in lymphoid tissues: 7-alpha,25-dihydroxycholesterol (7-alpha,25-OHC) acts as a ligand for the G protein-coupled receptor GPR183/EBI2, a chemotactic receptor for a number of lymphoid cells (By similarity). This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum membrane protein catalyzes the first reaction in the cholesterol catabolic pathway of extrahepatic tissues, which converts cholesterol to bile acids. This enzyme likely plays a minor role in total bile acid synthesis, but may also be involved in the development of atherosclerosis, neurosteroid metabolism and sex hormone synthes ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000310193
  • ENSP00000310721
  • ENSG00000172817

Symbol
  • CP7B
  • CBAS3
  • SPG5A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
pathway
0.79
gene perturbation
0.75
trait
0.75
PubMedID
0.72
histone modification site profile
0.67


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 83.53   (req: < 5)
Gene RIFs: 39   (req: <= 3)
Antibodies: 266   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 83.53   (req: >= 5)
Gene RIFs: 39   (req: > 3)
Antibodies: 266   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
unipolar depression
1
1
0
1
88.5
neuroticism measurement
3
3
1
5.7
87.1
wellbeing measurement
1
1
1
72.9
depressive symptom measurement
1
1
1
70.3
risk-taking behaviour
1
1
1
56.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
unipolar depression
0
1
88.5
neuroticism measurement
1
5.7
87.1
wellbeing measurement
1
72.9
depressive symptom measurement
1
70.3
risk-taking behaviour
1
56.9
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cytochrome P450 family 7 subfamily B member 1
VGNC:6564
743817
Macaque
25-hydroxycholesterol 7-alpha-hydroxylase
710188
Mouse
MGI:104978
13123
Rat
RGD:2483
25429
Dog
cytochrome P450 family 7 subfamily B member 1
VGNC:50379
486973
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cytochrome P450 family 7 subfamily B member 1
Macaque
25-hydroxycholesterol 7-alpha-hydroxylase
Mouse
Rat
Dog
cytochrome P450 family 7 subfamily B member 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O75881-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (26)
Bile acid and bile salt metabolism (R-HSA-194068)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Bile acid and bile salt metabolism
Reactome
Biological oxidations
Reactome
Cytochrome P450 - arranged by substrate type
Reactome
Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3)
Reactome
Disease
Name
Explore in Pharos
Explore in Source
Bile acid and bile salt metabolism
Biological oxidations
Cytochrome P450 - arranged by substrate type
Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3)
Disease
Gene Ontology Terms (13)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (100)
1 – 10 of 100
UBB
Tbio
Novelty: 0.00661254
p_int: 0.981719247
p_ni: 0.018280753
Score: 0.181
Data Source: BioPlex,STRINGDB
GHITM
Tbio
Novelty: 0.00360652
p_int: 0.818644383
p_ni: 0.181355584
p_wrong: 3.2e-8
Score: 0.188
Data Source: BioPlex,STRINGDB
CH25H
Tbio
Family: Enzyme
Novelty: 0.01620877
Score: 0.988
Data Source: STRINGDB
HSD3B7
Tbio
Family: Enzyme
Novelty: 0.04791842
Score: 0.98
Data Source: STRINGDB
HSD3B1
Tchem
Family: Enzyme
Novelty: 0.0019271
Score: 0.95
Data Source: STRINGDB
HSD3B2
Tclin
Family: Enzyme
Novelty: 0.00711552
Score: 0.947
Data Source: STRINGDB
CYP27A1
Tchem
Family: Enzyme
Novelty: 0.00071796
Score: 0.94
Data Source: STRINGDB
SULT2B1
Tbio
Family: Enzyme
Novelty: 0.02652128
Score: 0.924
Data Source: STRINGDB
CYP17A1
Tclin
Family: Enzyme
Novelty: 0.00065091
Score: 0.92
Data Source: STRINGDB
CYP21A2
Tchem
Family: Enzyme
Novelty: 0.00110959
Score: 0.918
Data Source: STRINGDB
Publication Statistics
PubMed Score  83.53

PubMed score by year
PubTator Score  65.84

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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