Tbio CYP7B1 25-hydroxycholesterol 7-alpha-hydroxylase

Protein Summary

Description

Oxysterol 7alpha-hydroxylase that mediates formation of 7-alpha,25-dihydroxycholesterol (7-alpha,25-OHC) from 25-hydroxycholesterol (PubMed:10588945). Plays a key role in cell positioning and movement in lymphoid tissues: 7-alpha,25-dihydroxycholesterol (7-alpha,25-OHC) acts as a ligand for the G protein-coupled receptor GPR183/EBI2, a chemotactic receptor for a number of lymphoid cells (By similarity). This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum membrane protein catalyzes the first reaction in the cholesterol catabolic pathway of extrahepatic tissues, which converts cholesterol to bile acids. This enzyme likely plays a minor role in total bile acid synthesis, but may also be involved in the development of atherosclerosis, neurosteroid metabolism and sex hormone synthesis. Mutations in this gene have been associated with hereditary spastic paraplegia (SPG5 or HSP), an autosomal recessive disorder. [provided by RefSeq, Apr 2016]

Uniprot Accession IDs

• O75881
• B2RN07
• Q9UNF5

Gene Name

• CYP7B1

Ensembl ID

• ENST00000310193
• ENSP00000310721
• ENSG00000172817

Symbol

• CP7B
• CBAS3
• SPG5A

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
pathway	0.79
gene perturbation	0.75
trait	0.75
PubMedID	0.72
histone modification site profile	0.67

Protein Classes

PANTHER Classes

Protein / Oxidoreductase / Oxygenase / 25-hydroxycholesterol 7-alpha-hydroxylase

DTO Classes

Protein / Enzyme / Oxidoreductase / Oxygenase / 25-hydroxycholesterol 7-alpha-hydroxylase

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 98.95   (req: < 5)

Gene RIFs: 44   (req: <= 3)

Antibodies: 266   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 98.95   (req: >= 5)

Gene RIFs: 44   (req: > 3)

Antibodies: 266   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0