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Tbio
SCO1
Protein SCO1 homolog, mitochondrial

Protein Summary
Description
Copper metallochaperone essential for the maturation of cytochrome c oxidase subunit II (MT-CO2/COX2). Not required for the synthesis of MT-CO2/COX2 but plays a crucial role in stabilizing MT-CO2/COX2 during its subsequent maturation. Involved in transporting copper to the Cu(A) site on MT-CO2/COX2 (PubMed:15659396, PubMed:16735468, PubMed:17189203, PubMed:19336478, PubMed:15229189). Plays an important role in the regulation of copper homeostasis by controlling the abundance and cell membrane localization of copper transporter CTR1 (By similarity). Mammalian cytochrome c oxidase (COX) catalyzes the transfer of reducing equivalents from cytochrome c to molecular oxygen and pumps protons across the inner mitochondrial membrane. In yeast, 2 related COX assembly genes, SCO1 and SCO2 (synthesis of cytochrome c oxidase), enable subunits 1 and 2 to be incorporated into the holoprotein. This gene is the human homolog to the yeast SCO1 gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000255390
  • ENSP00000255390
  • ENSG00000133028

Symbol
  • SCOD1
  • SCOD1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.87
transcription factor binding site profile
0.74
cell type or tissue
0.69
tissue
0.6
cellular component
0.59


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 105.15   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 145   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 105.15   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 145   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (107)
CYCS
Tchem
Novelty:  0.00014004
Score:  0.978
Data Source:  STRINGDB
COX17
Tbio
Family:  Enzyme
Novelty:  0.01025112
Score:  0.959
Data Source:  STRINGDB
COX11
Tbio
Family:  Enzyme
Novelty:  0.02572582
Score:  0.959
Data Source:  STRINGDB
COX15
Tbio
Family:  Enzyme
Novelty:  0.02252282
Score:  0.954
Data Source:  STRINGDB
SURF1
Tbio
Novelty:  0.00717605
Score:  0.921
Data Source:  STRINGDB
COX19
Tbio
Family:  Enzyme
Novelty:  0.06540633
Score:  0.894
Data Source:  STRINGDB
COX10
Tbio
Family:  Enzyme
Novelty:  0.0156235
Score:  0.893
Data Source:  STRINGDB
MT-CO2
Tchem
Family:  Enzyme
Novelty:  0.00073921
Score:  0.889
Data Source:  STRINGDB
NDUFS7
Tclin
Family:  Enzyme
Novelty:  0.01562198
Score:  0.88
Data Source:  STRINGDB
MT-CO1
Tchem
Family:  Enzyme
Novelty:  0.00008262
Score:  0.837
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (65)
Gene expression (Transcription) (R-HSA-74160)

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Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Metabolism
Reactome
RNA Polymerase II Transcription
Reactome
Respiratory electron transport
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
Metabolism
RNA Polymerase II Transcription
Respiratory electron transport
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (11)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SCO1, cytochrome c oxidase assembly protein
VGNC:9585
745696
Macaque
protein SCO1 homolog, mitochondrial
722074
Mouse
MGI:106362
52892
Rat
RGD:1559538
497930
Dog
SCO1, cytochrome c oxidase assembly protein
VGNC:45929
489505
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SCO1, cytochrome c oxidase assembly protein
Macaque
protein SCO1 homolog, mitochondrial
Mouse
Rat
Dog
SCO1, cytochrome c oxidase assembly protein
Publication Statistics
PubMed Score 105.15
PubMed score by year
PubTator Score 33.75
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title