Tclin IDH1 Isocitrate dehydrogenase [NADP] cytoplasmic

Protein Summary

Description

Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the cytoplasm and peroxisomes. It contains the PTS-1 peroxisomal targeting signal sequence. The presence of this enzyme in peroxisomes suggests roles in the regeneration of NADPH for intraperoxisomal reductions, such as the conversion of 2, 4-dienoyl-CoAs to 3-enoyl-CoAs, as well as in peroxisomal reactions that consume 2-oxoglutarate, namely the alpha-hydroxylation of phytanic acid. The cytoplasmic enzyme serves a significant role in cytoplasmic NADPH production. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2013]

Uniprot Accession IDs

• O75874
• Q567U4
• Q6FHQ6
• Q7Z3V0
• Q93090
• Q9NTJ9
• Q9UKW8
• IDH

Gene Name

• IDH1

Ensembl ID

• ENST00000345146
• ENSP00000260985
• ENSG00000138413
• ENST00000415913
• ENSP00000390265
• ENST00000446179
• ENSP00000410513

Symbol

• PICD
• IDH
• IDP
• IDCD
• IDPC
• PICD
• HEL-216
• HEL-S-26

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological term	1
transcription factor perturbation	0.99
disease perturbation	0.93
kinase perturbation	0.91
transcription factor binding site profile	0.87

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3017.82   (req: < 5)

Gene RIFs: 850   (req: <= 3)

Antibodies: 843   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3017.82   (req: >= 5)

Gene RIFs: 850   (req: > 3)

Antibodies: 843   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 1288

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1