IDH1
Isocitrate dehydrogenase [NADP] cytoplasmic
Protein Summary
Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the cytoplasm and peroxisomes. It contains the PTS-1 peroxisomal targeting signal sequence. The presence of this enzyme in peroxisomes suggests roles in the regeneration of NADPH for intraperoxisomal reductions, such as the conversion of 2, 4-dienoyl-CoAs to 3-enoyl-CoAs, as well as in peroxisomal reactions that consume 2-oxoglutarate, namely the alpha-hydroxylation o ...more
- ENST00000345146
- ENSP00000260985
- ENSG00000138413
- ENST00000415913
- ENSP00000390265
- ENST00000446179
- ENSP00000410513
- PICD
- IDH
- IDP
- IDCD
- IDPC
- PICD
- HEL-216
- HEL-S-26
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological term | 1 | ||
transcription factor perturbation | 0.99 | ||
disease perturbation | 0.93 | ||
kinase perturbation | 0.91 | ||
transcription factor binding site profile | 0.87 | ||
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2052.76 (req: < 5)
Gene RIFs: 585 (req: <= 3)
Antibodies: 843 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2052.76 (req: >= 5)
Gene RIFs: 585 (req: > 3)
Antibodies: 843 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 23
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 706
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
Active Ligands (706)
1 – 10 of 706
Protein Data Bank (36)
1 – 5 of 36
PDB Structure Id | Ligand | Method | Resolution (Å) | M.W. (kDa) | Pub Year | Title |
|---|
PDB Structure Id | M.W. | Resolution | Pub Year |
|---|
Pathways (30)
Reactome (12)
KEGG (8)
WikiPathways (10)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 12
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate | ||||
Reactome | Disease | ||||
Reactome | Diseases of metabolism | ||||
Reactome | Immune System | ||||
Reactome | Innate Immune System | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate | ||||
Disease | ||||
Diseases of metabolism | ||||
Immune System | ||||
Innate Immune System | ||||
Gene Ontology Terms (33)
Functions (9)
Components (10)
Processes (14)
Items per page:
10
1 – 9 of 9
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Experiment (EXP) | Reactome | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | IntAct | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from High Throughput Direct Assay (HDA) | BHF-UCL | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Protein-Protein Interactions (376)
1 – 10 of 376
IDH3B
Family: Enzyme
Novelty: 0.08029569
Score: 0.995
Data Source: STRINGDB
IDH3G
Family: Enzyme
Novelty: 0.10433606
Score: 0.995
Data Source: STRINGDB
IDH3A
Family: Enzyme
Novelty: 0.02666246
Score: 0.989
Data Source: STRINGDB
OGDH
Family: Enzyme
Novelty: 0.01059143
Score: 0.987
Data Source: STRINGDB
ACO2
Family: Enzyme
Novelty: 0.00277235
Score: 0.979
Data Source: STRINGDB
IDH2
Family: Enzyme
Novelty: 0.00094359
Score: 0.976
Data Source: STRINGDB
ACO1
Family: Enzyme
Novelty: 0.00249122
Score: 0.971
Data Source: STRINGDB
PGM1
Family: Enzyme
Novelty: 0.00195415
Score: 0.964
Data Source: STRINGDB
HSD17B4
Novelty: 0.00700004
Score: 0.957
Data Source: STRINGDB
CAT
Family: Enzyme
Novelty: 0.00022628
Score: 0.951
Data Source: STRINGDB
Publication Statistics
PubMed Score 2052.76
PubMed score by year
PubTator Score 1729.94
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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