IDH1
Isocitrate dehydrogenase [NADP] cytoplasmic
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Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
biological term | 1 | ||
transcription factor perturbation | 0.99 | ||
disease perturbation | 0.93 | ||
kinase perturbation | 0.91 | ||
transcription factor binding site profile | 0.87 | ||
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
- OR - satisfy the following criterion:
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Target has at least one approved drug - AND - satisfies the preceding conditions
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Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate | ||||
Reactome | Disease | ||||
Reactome | Diseases of metabolism | ||||
Reactome | Immune System | ||||
Reactome | Innate Immune System | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate | ||||
Disease | ||||
Diseases of metabolism | ||||
Immune System | ||||
Innate Immune System | ||||
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Experiment (EXP) | Reactome | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | IntAct | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from High Throughput Direct Assay (HDA) | BHF-UCL | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
1 | 1 | 0 | 1.2 | 42.3 | |||||
1 | 1 | 0 | 1.2 | 42.3 | |||||
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
0 | 1.2 | 42.3 | |||||
0 | 1.2 | 42.3 | |||||
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | isocitrate dehydrogenase (NADP(+)) 1, cytosolic | VGNC:1968 | 460113 | |||||
Macaque | isocitrate dehydrogenase (NADP(+)) 1, cytosolic | 710019 | ||||||
Mouse | MGI:96413 | 15926 | ||||||
Rat | RGD:2862 | 24479 | ||||||
Dog | isocitrate dehydrogenase (NADP(+)) 1, cytosolic | 478889 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | isocitrate dehydrogenase (NADP(+)) 1, cytosolic | |||||
Macaque | isocitrate dehydrogenase (NADP(+)) 1, cytosolic | |||||
Mouse | ||||||
Rat | ||||||
Dog | isocitrate dehydrogenase (NADP(+)) 1, cytosolic | |||||
PMID | Year | Title |
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