IDH1
Isocitrate dehydrogenase [NADP] cytoplasmic
Protein Summary
Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the cytoplasm and peroxisomes. It contains the PTS-1 peroxisomal targeting signal sequence. The presence of this enzyme in peroxisomes suggests roles in the regeneration of NADPH for intraperoxisomal reductions, such as the conversion of 2, 4-dienoyl-CoAs to 3-enoyl-CoAs, as well as in peroxisomal reactions that consume 2-oxoglutarate, namely the alpha-hydroxylation o ...more
- ENST00000345146
- ENSP00000260985
- ENSG00000138413
- ENST00000415913
- ENSP00000390265
- ENST00000446179
- ENSP00000410513
- PICD
- IDH
- IDP
- IDCD
- IDPC
- PICD
- HEL-216
- HEL-S-26
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological term | 1 | ||
transcription factor perturbation | 0.99 | ||
disease perturbation | 0.93 | ||
kinase perturbation | 0.91 | ||
transcription factor binding site profile | 0.87 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2386.92 (req: < 5)
Gene RIFs: 585 (req: <= 3)
Antibodies: 843 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2386.92 (req: >= 5)
Gene RIFs: 585 (req: > 3)
Antibodies: 843 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 23
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 1230
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 1
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (1)
Active Ligands (1230)
Protein-Protein Interactions (376)
Nearest Tclin Targets (2)
Upstream (1)
Downstream (1)
1 – 1 of 1
IDH2
Pathways (30)
Reactome (12)
KEGG (8)
WikiPathways (10)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate | ||||
Reactome | Disease | ||||
Reactome | Diseases of metabolism | ||||
Reactome | Immune System | ||||
Reactome | Innate Immune System | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate | ||||
Disease | ||||
Diseases of metabolism | ||||
Immune System | ||||
Innate Immune System | ||||
Viral Interactions (0)
Gene Ontology Terms (33)
Functions (9)
Components (10)
Processes (14)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Experiment (EXP) | Reactome | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | IntAct | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from High Throughput Direct Assay (HDA) | BHF-UCL | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations ()
GWAS Traits (2)
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
1 | 1 | 0 | 1.2 | 42.3 | |||||
1 | 1 | 0 | 1.2 | 42.3 | |||||
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
0 | 1.2 | 42.3 | |||||
0 | 1.2 | 42.3 | |||||
Find similar targets by:
IDG Resources
Orthologs (15)
1 – 5 of 15
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | isocitrate dehydrogenase (NADP(+)) 1, cytosolic | VGNC:1968 | 460113 | |||||
Macaque | isocitrate dehydrogenase (NADP(+)) 1, cytosolic | 710019 | ||||||
Mouse | MGI:96413 | 15926 | ||||||
Rat | RGD:2862 | 24479 | ||||||
Dog | isocitrate dehydrogenase (NADP(+)) 1, cytosolic | 478889 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | isocitrate dehydrogenase (NADP(+)) 1, cytosolic | |||||
Macaque | isocitrate dehydrogenase (NADP(+)) 1, cytosolic | |||||
Mouse | ||||||
Rat | ||||||
Dog | isocitrate dehydrogenase (NADP(+)) 1, cytosolic | |||||
Publication Statistics
PubMed Score 2386.92
PubMed score by year
PubTator Score 1729.94
PubTator score by year
Related Publications
Text Mined References (615)
GeneRif Annotations (585)
Items per page:
0 of 0
PMID | Year | Title |
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