IDH1
Isocitrate dehydrogenase [NADP] cytoplasmic
Protein Summary
Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the cytoplasm and peroxisomes. It contains the PTS-1 peroxisomal targeting signal sequence. The presence of this enzyme in peroxisomes suggests roles in the regeneration of NADPH for intraperoxisomal reductions, such as the conversion of 2, 4-dienoyl-CoAs to 3-enoyl-CoAs, as well as in peroxisomal reactions that consume 2-oxoglutarate, namely the alpha-hydroxylation o ...more
- ENST00000345146
- ENSP00000260985
- ENSG00000138413
- ENST00000415913
- ENSP00000390265
- ENST00000446179
- ENSP00000410513
- PICD
- IDH
- IDP
- IDCD
- IDPC
- PICD
- HEL-216
- HEL-S-26
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological term | 1 | ||
transcription factor perturbation | 0.99 | ||
disease perturbation | 0.93 | ||
kinase perturbation | 0.91 | ||
transcription factor binding site profile | 0.87 | ||
Related Tools
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2261.54 (req: < 5)
Gene RIFs: 585 (req: <= 3)
Antibodies: 843 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2261.54 (req: >= 5)
Gene RIFs: 585 (req: > 3)
Antibodies: 843 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 23
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 706
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
Active Ligands (706)
1 – 10 of 706
Orthologs (15)
1 – 5 of 15
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | isocitrate dehydrogenase (NADP(+)) 1, cytosolic | VGNC:1968 | 460113 | |||||
Macaque | isocitrate dehydrogenase (NADP(+)) 1, cytosolic | 710019 | ||||||
Mouse | MGI:96413 | 15926 | ||||||
Rat | RGD:2862 | 24479 | ||||||
Dog | isocitrate dehydrogenase (NADP(+)) 1, cytosolic | 478889 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | isocitrate dehydrogenase (NADP(+)) 1, cytosolic | |||||
Macaque | isocitrate dehydrogenase (NADP(+)) 1, cytosolic | |||||
Mouse | ||||||
Rat | ||||||
Dog | isocitrate dehydrogenase (NADP(+)) 1, cytosolic | |||||
Protein Data Bank (36)
1 – 5 of 36
PDB Structure Id | Ligand | Method | Resolution (Å) | M.W. (kDa) | Pub Year | Title |
|---|
PDB Structure Id | M.W. | Resolution | Pub Year |
|---|
Pathways (30)
Reactome (12)
KEGG (8)
WikiPathways (10)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 12
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate | ||||
Reactome | Disease | ||||
Reactome | Diseases of metabolism | ||||
Reactome | Immune System | ||||
Reactome | Innate Immune System | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate | ||||
Disease | ||||
Diseases of metabolism | ||||
Immune System | ||||
Innate Immune System | ||||
Gene Ontology Terms (33)
Functions (9)
Components (10)
Processes (14)
Items per page:
10
1 – 9 of 9
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Experiment (EXP) | Reactome | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | IntAct | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from High Throughput Direct Assay (HDA) | BHF-UCL | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Protein-Protein Interactions (376)
1 – 10 of 376
IDH3B
Family: Enzyme
Novelty: 0.04326765
Score: 0.995
Data Source: STRINGDB
IDH3G
Family: Enzyme
Novelty: 0.04861242
Score: 0.995
Data Source: STRINGDB
IDH3A
Family: Enzyme
Novelty: 0.02027198
Score: 0.989
Data Source: STRINGDB
OGDH
Family: Enzyme
Novelty: 0.00674601
Score: 0.987
Data Source: STRINGDB
ACO2
Family: Enzyme
Novelty: 0.00276725
Score: 0.979
Data Source: STRINGDB
IDH2
Family: Enzyme
Novelty: 0.00131782
Score: 0.976
Data Source: STRINGDB
ACO1
Family: Enzyme
Novelty: 0.00194023
Score: 0.971
Data Source: STRINGDB
PGM1
Family: Enzyme
Novelty: 0.00163947
Score: 0.964
Data Source: STRINGDB
HSD17B4
Novelty: 0.00547499
Score: 0.957
Data Source: STRINGDB
CAT
Family: Enzyme
Novelty: 0.00181888
Score: 0.951
Data Source: STRINGDB
Publication Statistics
PubMed Score 2261.54
PubMed score by year
PubTator Score 1729.94
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by:
UniProt Keyword