You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
TRAPPC6A
Trafficking protein particle complex subunit 6A

Protein Summary
Description
May play a role in vesicular transport during the biogenesis of melanosomes. This gene encodes a component of the trafficking protein particle complex, which tethers transport vesicles to the cis-Golgi membrane. Loss of expression of the related gene in mouse affects coat and eye pigmentation, suggesting that the encoded protein may be involved in melanosome biogenesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000006275
  • ENSP00000006275
  • ENSG00000007255
  • ENST00000585934
  • ENSP00000468612
  • ENST00000588062
  • ENSP00000468363
  • ENST00000592647
  • ENSP00000468182

Symbol
  • TRS33
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.72
transcription factor perturbation
0.68
transcription factor
0.66
gene perturbation
0.57
tissue sample
0.56


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.22   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 118   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.22   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 118   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (39)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
4
3
5
98
platelet count
3
5
4
2.6
97.6
leukocyte count
2
3
3
97.4
2
11
0
7
97.3
family history of Alzheimer’s disease
1
9
0
7.2
97.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
5
98
platelet count
4
2.6
97.6
leukocyte count
3
97.4
0
7
97.3
family history of Alzheimer’s disease
0
7.2
97.2
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
trafficking protein particle complex 6A
713880
Mouse
MGI:1914341
67091
Rat
RGD:1591735
680465
Dog
trafficking protein particle complex 6A
VGNC:47785
612313
Horse
trafficking protein particle complex 6A
VGNC:24475
100065619
Species
Name
OMA
EggNOG
Inparanoid
Macaque
trafficking protein particle complex 6A
Mouse
Rat
Dog
trafficking protein particle complex 6A
Horse
trafficking protein particle complex 6A
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O75865-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (10)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
COPII-mediated vesicle transport
Reactome
ER to Golgi Anterograde Transport
Reactome
Membrane Trafficking
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
COPII-mediated vesicle transport
ER to Golgi Anterograde Transport
Membrane Trafficking
Metabolism of proteins
Gene Ontology Terms (10)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (103)
1 – 10 of 103
TRAPPC1
Tbio
Novelty:  0.09781468
p_int:  0.999999899
p_ni:  9.6e-8
p_wrong:  4e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
TRAPPC2
Tbio
Novelty:  0.02016231
p_int:  0.999999819
p_ni:  1.81e-7
Score:  0.998
Data Source:  BioPlex,STRINGDB
TRAPPC5
Tdark
Novelty:  0.22558077
p_int:  0.999999813
p_ni:  1.87e-7
p_wrong:  1e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
TRAPPC12
Tbio
Novelty:  0.09847363
p_int:  0.999988145
p_ni:  0.000010184
p_wrong:  0.00000167
Score:  0.993
Data Source:  BioPlex,STRINGDB
TRAPPC3
Tbio
Novelty:  0.0360262
Score:  0.997
Data Source:  STRINGDB
TRAPPC9
Tbio
Novelty:  0.02703008
Score:  0.996
Data Source:  STRINGDB
TRAPPC4
Tbio
Novelty:  0.05749912
Score:  0.994
Data Source:  STRINGDB
TRAPPC2L
Tdark
Novelty:  0.41040339
Score:  0.993
Data Source:  STRINGDB
TRAPPC8
Tdark
Novelty:  0.07711264
Score:  0.993
Data Source:  STRINGDB
TRAPPC10
Tbio
Novelty:  0.03433058
Score:  0.988
Data Source:  STRINGDB
Publication Statistics
PubMed Score  9.22

PubMed score by year
PubTator Score  4.52

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: