Tbio TRAPPC6A Trafficking protein particle complex subunit 6A

Protein Summary

Description

May play a role in vesicular transport during the biogenesis of melanosomes. This gene encodes a component of the trafficking protein particle complex, which tethers transport vesicles to the cis-Golgi membrane. Loss of expression of the related gene in mouse affects coat and eye pigmentation, suggesting that the encoded protein may be involved in melanosome biogenesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012]

Uniprot Accession IDs

• O75865
• K7ERB1
• K7ERQ4
• Q9BQ45
• Q9P092
• TRAPP complex subunit 6A

Gene Name

• TRAPPC6A

Ensembl ID

• ENST00000006275
• ENSP00000006275
• ENSG00000007255
• ENST00000585934
• ENSP00000468612
• ENST00000588062
• ENSP00000468363
• ENST00000592647
• ENSP00000468182

Symbol

• TRS33

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor binding site profile	0.72
transcription factor perturbation	0.68
transcription factor	0.66
gene perturbation	0.57
tissue sample	0.56

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.75   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 118   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.75   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 118   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0