Protein Summary
Catalyzes a dehydrogenation to introduce C5-6 double bond into lathosterol. This gene encodes an enzyme of cholesterol biosynthesis. The encoded protein catalyzes the conversion of lathosterol into 7-dehydrocholesterol. Mutations in this gene have been associated with lathosterolosis. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]
- ENST00000264027
- ENSP00000264027
- ENSG00000109929
- ENST00000392789
- ENSP00000376539
- SC5DL
- ERG3
- S5DES
- SC5DL
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
transcription factor perturbation | 0.96 | ||
kinase perturbation | 0.81 | ||
small molecule perturbation | 0.73 | ||
transcription factor binding site profile | 0.69 | ||
histone modification site profile | 0.67 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 51.33 (req: < 5)
Gene RIFs: 4 (req: <= 3)
Antibodies: 34 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 51.33 (req: >= 5)
Gene RIFs: 4 (req: > 3)
Antibodies: 34 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0