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Tbio
SC5D
Lathosterol oxidase

Protein Summary
Description
Catalyzes a dehydrogenation to introduce C5-6 double bond into lathosterol. This gene encodes an enzyme of cholesterol biosynthesis. The encoded protein catalyzes the conversion of lathosterol into 7-dehydrocholesterol. Mutations in this gene have been associated with lathosterolosis. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264027
  • ENSP00000264027
  • ENSG00000109929
  • ENST00000392789
  • ENSP00000376539

Symbol
  • SC5DL
  • ERG3
  • S5DES
  • SC5DL
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.96
kinase perturbation
0.81
small molecule perturbation
0.73
transcription factor binding site profile
0.69
histone modification site profile
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.33   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 34   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.33   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 34   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0