ZMPSTE24
CAAX prenyl protease 1 homolog
Protein Summary
Proteolytically removes the C-terminal three residues of farnesylated proteins. Acts on lamin A/C. This gene encodes a member of the peptidase M48A family. The encoded protein is a zinc metalloproteinase involved in the two step post-translational proteolytic cleavage of carboxy terminal residues of farnesylated prelamin A to form mature lamin A. Mutations in this gene have been associated with mandibuloacral dysplasia and restrictive dermopathy. [provided by RefSeq, Jul 2008]
- ENST00000372759
- ENSP00000361845
- ENSG00000084073
- FACE1
- STE24
- HGPS
- PRO1
- FACE1
- STE24
- FACE-1
- Ste24p
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
kinase perturbation | 1 | ||
histone modification site profile | 0.87 | ||
interacting protein | 0.84 | ||
disease perturbation | 0.79 | ||
transcription factor binding site profile | 0.79 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 367.5 (req: < 5)
Gene RIFs: 49 (req: <= 3)
Antibodies: 387 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 367.5 (req: >= 5)
Gene RIFs: 49 (req: > 3)
Antibodies: 387 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 53
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0