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Tbio
ZMPSTE24
CAAX prenyl protease 1 homolog

Protein Summary
Description
Proteolytically removes the C-terminal three residues of farnesylated proteins. Acts on lamin A/C. This gene encodes a member of the peptidase M48A family. The encoded protein is a zinc metalloproteinase involved in the two step post-translational proteolytic cleavage of carboxy terminal residues of farnesylated prelamin A to form mature lamin A. Mutations in this gene have been associated with mandibuloacral dysplasia and restrictive dermopathy. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000372759
  • ENSP00000361845
  • ENSG00000084073

Symbol
  • FACE1
  • STE24
  • HGPS
  • PRO1
  • FACE1
  • STE24
  • FACE-1
  • Ste24p
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
histone modification site profile
0.87
interacting protein
0.84
disease perturbation
0.79
transcription factor binding site profile
0.79


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 312.63   (req: < 5)
Gene RIFs: 36   (req: <= 3)
Antibodies: 387   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 312.63   (req: >= 5)
Gene RIFs: 36   (req: > 3)
Antibodies: 387   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 53
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (118)
SLC18A1
Tchem
Family:  Transporter
Novelty:  0.01135292
p_int:  0.999332915
p_ni:  0.000667085
Data Source:  BioPlex
TNFRSF17
Tclin
Novelty:  0.00222663
p_int:  0.997526573
p_ni:  0.002473358
p_wrong:  6.9e-8
Score:  0.177
Data Source:  BioPlex,STRINGDB
GDPD5
Tbio
Family:  Enzyme
Novelty:  0.05871733
p_int:  0.997431027
p_ni:  0.002568971
p_wrong:  2e-9
Score:  0.179
Data Source:  BioPlex,STRINGDB
IL7
Tbio
Novelty:  0.00054101
p_int:  0.995721301
p_ni:  0.004275188
p_wrong:  0.000003511
Data Source:  BioPlex
TMEM196
Tdark
Novelty:  0.37594264
p_int:  0.991919328
p_ni:  0.008080651
p_wrong:  2.1e-8
Data Source:  BioPlex
VAC14
Tbio
Novelty:  0.02677738
p_int:  0.990638547
p_ni:  0.009361448
p_wrong:  5e-9
Data Source:  BioPlex
FDPS
Tclin
Family:  Enzyme
Novelty:  0.00164195
p_int:  0.990153026
p_ni:  0.009846961
p_wrong:  1.3e-8
Score:  0.287
Data Source:  BioPlex,STRINGDB
MED21
Tbio
Family:  Enzyme
Novelty:  0.06996616
p_int:  0.982610974
p_ni:  0.017389002
p_wrong:  2.4e-8
Data Source:  BioPlex
DEFB4A
Tbio
Novelty:  0.0017451
p_int:  0.980841365
p_ni:  0.019158601
p_wrong:  3.4e-8
Data Source:  BioPlex
GPR21
Tdark
Family:  GPCR
Novelty:  0.90865557
p_int:  0.973487301
p_ni:  0.026510581
p_wrong:  0.000002118
Data Source:  BioPlex
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
1
1
1
70.9
platelet count
1
1
1
42.3
BMI-adjusted hip circumference
1
1
1
39.6
BMI-adjusted waist circumference
1
1
1
0.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
1
70.9
platelet count
1
42.3
BMI-adjusted hip circumference
1
39.6
BMI-adjusted waist circumference
1
0.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
zinc metallopeptidase STE24
VGNC:1633
456790
Macaque
zinc metallopeptidase STE24
693765
Mouse
MGI:1890508
230709
Rat
RGD:1305570
313564
Dog
zinc metallopeptidase STE24
VGNC:48644
482460
Species
Name
OMA
EggNOG
Inparanoid
Chimp
zinc metallopeptidase STE24
Macaque
zinc metallopeptidase STE24
Mouse
Rat
Dog
zinc metallopeptidase STE24
Publication Statistics
PubMed Score 312.63
PubMed score by year
PubTator Score 116.88
PubTator score by year
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Related Publications
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PMID
Year
Title