Tbio AP1G2 AP-1 complex subunit gamma-like 2

Protein Summary

Description

May function in protein sorting in late endosomes or multivesucular bodies (MVBs). (Microbial infection) Involved in MVB-assisted maturation of hepatitis B virus (HBV). Adaptins are important components of clathrin-coated vesicles transporting ligand-receptor complexes from the plasma membrane or from the trans-Golgi network to lysosomes. The adaptin family of proteins is composed of four classes of molecules named alpha, beta-, beta prime- and gamma- adaptins. Adaptins, together with medium and small subunits, form a heterotetrameric complex called an adaptor, whose role is to promote the formation of clathrin-coated pits and vesicles. The protein encoded by this gene is a gamma-adaptin protein and it belongs to the adaptor complexes large subunits family. This protein along with the complex is thought to function at some trafficking step in the complex pathways between the trans-Golgi network and the cell surface. [provided by RefSeq, Aug 2017]

Uniprot Accession IDs

• O75843
• D3DS51
• O75504

Gene Name

• AP1G2

Ensembl ID

• ENST00000308724
• ENSP00000312442
• ENSG00000213983
• ENST00000397120
• ENSP00000380309

Symbol

• G2AD

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.92
cellular component	0.79
gene perturbation	0.76
transcription factor	0.74
cell type or tissue	0.7

Protein Classes

PANTHER Classes

Protein / Transmembrane Receptor Regulatory/adaptor Protein / Ap-1 Complex Subunit Gamma-like 2

DTO Classes

Protein / Receptor / Ap-1 Complex Subunit Gamma-like 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.41   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 65   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.41   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 65   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0