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Tbio
CIB2
Calcium and integrin-binding family member 2

Protein Summary
Description
Calcium-binding protein critical for proper photoreceptor cell maintenance and function. Plays a role in intracellular calcium homeostasis by decreasing ATP-induced calcium release (PubMed:23023331, PubMed:26173970, PubMed:26426422). May be involved in the mechanotransduction process (By similarity). The protein encoded by this gene is similar to that of KIP/CIB, calcineurin B, and calmodulin. The encoded protein is a calcium-binding regulatory protein that interacts with DNA-dependent protein kinase catalytic subunits (DNA-PKcs), and it is involved in photoreceptor cell maintenance. Mutations in this gene cause deafness, autosomal recessive, 48 (DFNB48), and also Usher syndrome 1J (USH1J). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000258930
  • ENSP00000258930
  • ENSG00000136425
  • ENST00000539011
  • ENSP00000442459
  • ENST00000557846
  • ENSP00000453488

Symbol
  • KIP2
  • KIP2
  • USH1J
  • DFNB48
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.82
disease perturbation
0.74
PubMedID
0.61
disease
0.59
transcription factor perturbation
0.54


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.67   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 185   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.67   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 185   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (59)
PARD3B
Tbio
Novelty:  0.09155541
p_int:  0.999991589
p_ni:  0.000004584
p_wrong:  0.000003827
Data Source:  BioPlex
RAD21
Tbio
Novelty:  0.00270936
p_int:  0.997415756
p_ni:  0.002584164
p_wrong:  8e-8
Data Source:  BioPlex
B3GNT2
Tbio
Family:  Enzyme
Novelty:  0.02724566
p_int:  0.995187188
p_ni:  0.004812675
p_wrong:  1.36e-7
Data Source:  BioPlex
RNF19B
Tbio
Family:  Enzyme
Novelty:  0.20054824
p_int:  0.995060784
p_ni:  0.004692565
p_wrong:  0.000246651
Data Source:  BioPlex
FAM208A
Tbio
Novelty:  0.17789689
p_int:  0.994574981
p_ni:  0.005425018
p_wrong:  2e-9
Data Source:  BioPlex
PLD2
Tchem
Family:  Enzyme
Novelty:  0.00331129
p_int:  0.989661407
p_ni:  0.010338591
p_wrong:  2e-9
Data Source:  BioPlex
PDZD8
Tbio
Novelty:  0.09015543
p_int:  0.961375397
p_ni:  0.038624603
Data Source:  BioPlex
ATP13A2
Tbio
Family:  Transporter
Novelty:  0.00623191
p_int:  0.931830874
p_ni:  0.068169118
p_wrong:  7e-9
Score:  0.192
Data Source:  BioPlex,STRINGDB
EPHA4
Tchem
Family:  Kinase
Novelty:  0.00321698
p_int:  0.928727501
p_ni:  0.071269802
p_wrong:  0.000002697
Data Source:  BioPlex
SETX
Tbio
Family:  Enzyme
Novelty:  0.00474094
p_int:  0.920131074
p_ni:  0.079864297
p_wrong:  0.000004629
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum albumin measurement
1
2
2
78.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum albumin measurement
2
78.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
calcium and integrin binding family member 2
VGNC:2472
453564
Macaque
calcium and integrin binding family member 2
709429
Mouse
MGI:1929293
56506
Rat
RGD:1308718
300719
Dog
calcium and integrin binding family member 2
VGNC:39267
491539
Species
Name
OMA
EggNOG
Inparanoid
Chimp
calcium and integrin binding family member 2
Macaque
calcium and integrin binding family member 2
Mouse
Rat
Dog
calcium and integrin binding family member 2
Publication Statistics
PubMed Score 25.67
PubMed score by year
PubTator Score 12.78
PubTator score by year
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Related Publications
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PMID
Year
Title