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Tbio
CBR3
Carbonyl reductase [NADPH] 3

Protein Summary
Description
Has low NADPH-dependent oxidoreductase activity towards 4-benzoylpyridine and menadione (in vitro). Carbonyl reductase 3 catalyzes the reduction of a large number of biologically and pharmacologically active carbonyl compounds to their corresponding alcohols. The enzyme is classified as a monomeric NADPH-dependent oxidoreductase. CBR3 contains three exons spanning 11.2 kilobases and is closely linked to another carbonyl reductase gene - CBR1. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000290354
  • ENSP00000290354
  • ENSG00000159231

Symbol
  • hCBR3
  • SDR21C2
  • HEL-S-25
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.93
small molecule perturbation
0.81
interacting protein
0.79
kinase perturbation
0.76
disease perturbation
0.74


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 50.8   (req: < 5)
Gene RIFs: 24   (req: <= 3)
Antibodies: 286   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 50.8   (req: >= 5)
Gene RIFs: 24   (req: > 3)
Antibodies: 286   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
IGF-1 measurement
1
4
4
95.1
low density lipoprotein cholesterol measurement
1
1
1
38.8
C-reactive protein measurement
1
1
1
11.1
Mitral valve prolapse
1
1
0
1.2
2.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
IGF-1 measurement
4
95.1
low density lipoprotein cholesterol measurement
1
38.8
C-reactive protein measurement
1
11.1
Mitral valve prolapse
0
1.2
2.4
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
carbonyl reductase 3
VGNC:14652
458533
Mouse
MGI:1309992
109857
Rat
RGD:1309728
304078
Dog
carbonyl reductase 3
VGNC:38764
487748
Cow
carbonyl reductase 3
VGNC:53516
516036
Species
Name
OMA
EggNOG
Inparanoid
Chimp
carbonyl reductase 3
Mouse
Rat
Dog
carbonyl reductase 3
Cow
carbonyl reductase 3
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O75828-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (12)
Biological oxidations (R-HSA-211859)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Biological oxidations
Reactome
Metabolism
Reactome
Phase I - Functionalization of compounds
Name
Explore in Pharos
Explore in Source
Biological oxidations
Metabolism
Phase I - Functionalization of compounds
Protein-Protein Interactions (53)
1 – 10 of 53
CBR1
Tchem
Family:  Enzyme
Novelty:  0.0062295
p_int:  0.903060658
p_ni:  0.096939342
Score:  0.947
Data Source:  BioPlex,STRINGDB
BTBD9
Tbio
Novelty:  0.02793632
p_int:  0.865192653
p_ni:  0.134807346
Score:  0.514
Data Source:  BioPlex,STRINGDB
CYP2D6
Tclin
Family:  Enzyme
Novelty:  0.00021853
Score:  0.937
Data Source:  STRINGDB
CYP3A4
Tclin
Family:  Enzyme
Novelty:  0.00015515
Score:  0.921
Data Source:  STRINGDB
CYP1A1
Tchem
Novelty:  0.0002404
Score:  0.915
Data Source:  STRINGDB
CYP2E1
Tchem
Novelty:  0.00030504
Score:  0.913
Data Source:  STRINGDB
CYP2A13
Tchem
Novelty:  0.00697238
Score:  0.906
Data Source:  STRINGDB
CYP2A6
Tchem
Novelty:  0.00105285
Score:  0.906
Data Source:  STRINGDB
PTGES
Tchem
Family:  Enzyme
Novelty:  0.00146096
Score:  0.902
Data Source:  STRINGDB
PTGES2
Tchem
Family:  Enzyme
Novelty:  0.01415352
Score:  0.901
Data Source:  STRINGDB
Publication Statistics
PubMed Score  50.80

PubMed score by year
PubTator Score  45.4

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer