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Tbio
EIF3J
Eukaryotic translation initiation factor 3 subunit J

Protein Summary
Description
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). This gene enc ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261868
  • ENSP00000261868
  • ENSG00000104131
  • ENST00000424492
  • ENSP00000414548
  • ENST00000535391
  • ENSP00000440221

Symbol
  • EIF3S1
  • EIF3S1
  • eIF3-p35
  • eIF3-alpha
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug perturbation
0.96
kinase perturbation
0.95
transcription factor perturbation
0.91
histone modification site profile
0.89
transcription factor binding site profile
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.9   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 151   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.9   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 151   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (166)
CSNK2A2
Tchem
Family:  Kinase
Novelty:  0.00231447
p_int:  0.999999722
p_ni:  2.78e-7
Score:  0.542
Data Source:  BioPlex,STRINGDB
CSNK2B
Tbio
Family:  Kinase
Novelty:  0.00152367
p_int:  0.999981014
p_ni:  0.000018986
Data Source:  BioPlex
ARL6IP4
Tbio
Novelty:  0.01317084
p_int:  0.997884442
p_ni:  0.002115558
Score:  0.699
Data Source:  BioPlex,STRINGDB
PNKD
Tbio
Family:  Enzyme
Novelty:  0.02456078
p_int:  0.980517885
p_ni:  0.019482115
Data Source:  BioPlex
EIF3I
Tbio
Novelty:  0.04398155
p_int:  0.96906719
p_ni:  0.03093281
Score:  0.994
Data Source:  BioPlex,STRINGDB
CYP1A1
Tchem
Novelty:  0.0002404
p_int:  0.966428195
p_ni:  0.033571805
Data Source:  BioPlex
IFRD2
Tbio
Novelty:  0.03050513
p_int:  0.93789105
p_ni:  0.06210895
Score:  0.271
Data Source:  BioPlex,STRINGDB
NOP56
Tbio
Novelty:  0.01256937
p_int:  0.91964792
p_ni:  0.077901905
p_wrong:  0.002450175
Data Source:  BioPlex
FGB
Tbio
Novelty:  0.00437751
p_int:  0.907610895
p_ni:  0.092389105
Data Source:  BioPlex
GTF2E2
Tbio
Novelty:  0.18033153
p_int:  0.906378822
p_ni:  0.093621178
Score:  0.159
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (13)
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S (R-HSA-72662)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
Reactome
Cap-dependent Translation Initiation
Reactome
Eukaryotic Translation Initiation
Reactome
Formation of a pool of free 40S subunits
Reactome
Formation of the ternary complex, and subsequently, the 43S complex
Name
Explore in Pharos
Explore in Source
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
Cap-dependent Translation Initiation
Eukaryotic Translation Initiation
Formation of a pool of free 40S subunits
Formation of the ternary complex, and subsequently, the 43S complex
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (26)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
27
4
28
92.6
triglyceride measurement
19
2
20
91.7
C-reactive protein measurement
2
2
2
88.3
free cholesterol:total lipids ratio
8
3
8
86.1
low density lipoprotein cholesterol measurement
12
3
12
86.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
28
92.6
triglyceride measurement
20
91.7
C-reactive protein measurement
2
88.3
free cholesterol:total lipids ratio
8
86.1
low density lipoprotein cholesterol measurement
12
86.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
eukaryotic translation initiation factor 3 subunit J
712295
Mouse
MGI:1925905
78655
Mouse
MGI:3704486
100042807
Rat
RGD:1593338
691947
Dog
eukaryotic translation initiation factor 3 subunit J
VGNC:40276
487532
Species
Name
OMA
EggNOG
Inparanoid
Macaque
eukaryotic translation initiation factor 3 subunit J
Mouse
Mouse
Rat
Dog
eukaryotic translation initiation factor 3 subunit J
Publication Statistics
PubMed Score 23.90
PubMed score by year
PubTator Score 33.67
PubTator score by year
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Related Publications
Items per page:
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PMID
Year
Title