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Tbio
RPP40
Ribonuclease P protein subunit p40

Protein Summary
Description
Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000319533
  • ENSP00000317998
  • ENSG00000124787
  • ENST00000380051
  • ENSP00000369391

Symbol
  • RNASEP1
  • RNASEP1
  • bA428J1.3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.89
kinase perturbation
0.81
virus perturbation
0.76
tissue sample
0.65
transcription factor binding site profile
0.65


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.66   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 70   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.66   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 70   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (151)
RPP25L
Tdark
Family:  Enzyme
Novelty:  1.39761189
p_int:  0.999999254
p_ni:  7.46e-7
Score:  0.935
Data Source:  BioPlex,STRINGDB
POP5
Tbio
Family:  Enzyme
Novelty:  0.02459167
p_int:  0.999999068
p_ni:  9.32e-7
Score:  0.992
Data Source:  BioPlex,STRINGDB
RPP30
Tbio
Family:  Enzyme
Novelty:  0.01375777
p_int:  0.999998403
p_ni:  0.000001597
Score:  0.998
Data Source:  BioPlex,STRINGDB
RPP21
Tbio
Family:  Enzyme
Novelty:  0.05805689
p_int:  0.99999623
p_ni:  0.00000377
Score:  0.997
Data Source:  BioPlex,STRINGDB
RPP25
Tbio
Family:  Enzyme
Novelty:  0.07178063
p_int:  0.999996217
p_ni:  0.000003783
Score:  0.998
Data Source:  BioPlex,STRINGDB
C18orf21
Tdark
Novelty:  0.65363998
p_int:  0.999995063
p_ni:  0.000004937
Score:  0.826
Data Source:  BioPlex,STRINGDB
POP4
Tbio
Family:  Enzyme
Novelty:  0.01072287
p_int:  0.999992282
p_ni:  0.000007718
Score:  0.998
Data Source:  BioPlex,STRINGDB
NEPRO
Tbio
Novelty:  0.12980261
p_int:  0.998912226
p_ni:  0.001087771
p_wrong:  3e-9
Score:  0.357
Data Source:  BioPlex,STRINGDB
RBM4
Tbio
Novelty:  0.02034191
p_int:  0.997608529
p_ni:  0.002391471
Score:  0.22
Data Source:  BioPlex,STRINGDB
VTN
Tbio
Family:  TF
Novelty:  0.00046861
p_int:  0.995734273
p_ni:  0.00426565
p_wrong:  7.7e-8
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
Major pathway of rRNA processing in the nucleolus and cytosol (R-HSA-6791226)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Major pathway of rRNA processing in the nucleolus and cytosol
Reactome
Metabolism of RNA
Reactome
rRNA processing
Reactome
rRNA processing in the nucleus and cytosol
Reactome
tRNA processing
Name
Explore in Pharos
Explore in Source
Major pathway of rRNA processing in the nucleolus and cytosol
Metabolism of RNA
rRNA processing
rRNA processing in the nucleus and cytosol
tRNA processing
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.1
29
keratinocyte carcinoma
1
1
0
1.1
13.5
1
1
0
1.1
13.1
red blood cell distribution width
1
1
1
12
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
29
keratinocyte carcinoma
0
1.1
13.5
0
1.1
13.1
red blood cell distribution width
1
12
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ribonuclease P/MRP 40 subunit
VGNC:3688
471844
Macaque
ribonuclease P/MRP subunit p40
710505
Mouse
MGI:1346084
208366
Rat
RGD:1310228
291071
Dog
ribonuclease P/MRP subunit p40
VGNC:45725
478709
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ribonuclease P/MRP 40 subunit
Macaque
ribonuclease P/MRP subunit p40
Mouse
Rat
Dog
ribonuclease P/MRP subunit p40
Publication Statistics
PubMed Score 13.66
PubMed score by year
PubTator Score 1.87
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title