Tbio RPP40 Ribonuclease P protein subunit p40

Protein Summary

Description

Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

Uniprot Accession IDs

• O75818
• Q5VX97
• Q8WVK8
• RNaseP protein p40

Gene Name

• RPP40

Ensembl ID

• ENST00000319533
• ENSP00000317998
• ENSG00000124787
• ENST00000380051
• ENSP00000369391

Symbol

• RNASEP1
• RNASEP1
• bA428J1.3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.89
kinase perturbation	0.81
virus perturbation	0.76
tissue sample	0.65
transcription factor binding site profile	0.65

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.66   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 70   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.66   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 70   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (151)

Explore Interacting Targets

1 – 10 of 151

• See Interactions on String-DB

RPP25L

Tdark

Family:  Enzyme

Novelty:  1.39761189

p_int:  0.999999254

p_ni:  7.46e-7

Score:  0.935

Data Source:  BioPlex,STRINGDB

POP5

Tbio

Family:  Enzyme

Novelty:  0.02459167

p_int:  0.999999068

p_ni:  9.32e-7

Score:  0.992

Data Source:  BioPlex,STRINGDB

RPP30

Tbio

Family:  Enzyme

Novelty:  0.01375777

p_int:  0.999998403

p_ni:  0.000001597

Score:  0.998

Data Source:  BioPlex,STRINGDB

RPP21

Tbio

Family:  Enzyme

Novelty:  0.05805689

p_int:  0.99999623

p_ni:  0.00000377

Score:  0.997

Data Source:  BioPlex,STRINGDB

RPP25

Tbio

Family:  Enzyme

Novelty:  0.07178063

p_int:  0.999996217

p_ni:  0.000003783

Score:  0.998

Data Source:  BioPlex,STRINGDB

C18orf21

Tdark

Novelty:  0.65363998

p_int:  0.999995063

p_ni:  0.000004937

Score:  0.826

Data Source:  BioPlex,STRINGDB

POP4

Tbio

Family:  Enzyme

Novelty:  0.01072287

p_int:  0.999992282

p_ni:  0.000007718

Score:  0.998

Data Source:  BioPlex,STRINGDB

NEPRO

Tbio

Novelty:  0.12980261

p_int:  0.998912226

p_ni:  0.001087771

p_wrong:  3e-9

Score:  0.357

Data Source:  BioPlex,STRINGDB

RBM4

Tbio

Novelty:  0.02034191

p_int:  0.997608529

p_ni:  0.002391471

Score:  0.22

Data Source:  BioPlex,STRINGDB

VTN

Tbio

Family:  TF

Novelty:  0.00046861

p_int:  0.995734273

p_ni:  0.00426565

p_wrong:  7.7e-8

Data Source:  BioPlex

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (8)

Reactome (6)

KEGG (2)

Major pathway of rRNA processing in the nucleolus and cytosol (R-HSA-6791226)

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1 – 5 of 6

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Major pathway of rRNA processing in the nucleolus and cytosol	183 targets	R-HSA-6791226
Reactome	Metabolism of RNA	686 targets	R-HSA-8953854
Reactome	rRNA processing	217 targets	R-HSA-72312
Reactome	rRNA processing in the nucleus and cytosol	193 targets	R-HSA-8868773
Reactome	tRNA processing	123 targets	R-HSA-72306

Name	Explore in Pharos	Explore in Source
Major pathway of rRNA processing in the nucleolus and cytosol	183 targets	R-HSA-6791226
Metabolism of RNA	686 targets	R-HSA-8953854
rRNA processing	217 targets	R-HSA-72312
rRNA processing in the nucleus and cytosol	193 targets	R-HSA-8868773
tRNA processing	123 targets	R-HSA-72306

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (5)

Functions (1)

Components (3)

Processes (1)

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10

1 – 1 of 1

GO Term	Evidence	Assigned by
ribonuclease P activity	Traceable Author Statement (TAS)	ProtInc

Disease Associations ()

No disease associations found

GWAS Traits (4)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 4 of 4

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
basal cell carcinoma	EFO_0004193	1	1	0	1.1	29
keratinocyte carcinoma	EFO_0010176	1	1	0	1.1	13.5
squamous cell carcinoma	EFO_0000707	1	1	0	1.1	13.1
red blood cell distribution width	EFO_0005192	1	1	1		12

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 4 of 4

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
basal cell carcinoma	EFO_0004193	0	1.1	29
keratinocyte carcinoma	EFO_0010176	0	1.1	13.5
squamous cell carcinoma	EFO_0000707	0	1.1	13.1
red blood cell distribution width	EFO_0005192	1		12

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Complete proteome
Direct protein sequencing
Hydrolase
Nucleus
Polymorphism
Reference proteome
tRNA processing

GWAS Trait Find Similar Targets

No Header	No Header
basal cell carcinoma
keratinocyte carcinoma
red blood cell distribution width
squamous cell carcinoma

IDG Resources

No IDG generated resources found

Orthologs (13)

1 – 5 of 13

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	ribonuclease P/MRP 40 subunit	VGNC:3688	471844
Macaque	ribonuclease P/MRP subunit p40		710505
Mouse	ribonuclease P 40 subunit	MGI:1346084	208366
Rat	ribonuclease P/MRP subunit p40	RGD:1310228	291071
Dog	ribonuclease P/MRP subunit p40	VGNC:45725	478709

Species	Name	OMA	EggNOG	Inparanoid
Chimp	ribonuclease P/MRP 40 subunit
Macaque	ribonuclease P/MRP subunit p40
Mouse	ribonuclease P 40 subunit
Rat	ribonuclease P/MRP subunit p40
Dog	ribonuclease P/MRP subunit p40

Publication Statistics

PubMed Score 13.66

PubMed score by year

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PubTator Score 1.87

PubTator score by year

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Related Publications

Text Mined References (7)

GeneRif Annotations (2)

Items per page:

10

0 of 0

PMID	Year	Title