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Tbio
BCAR3
Breast cancer anti-estrogen resistance protein 3

Protein Summary
Description
May act as an adapter protein and couple activated growth factor receptors to a signaling pathway that regulates the proliferation in breast cancer cells. When overexpressed, it confers anti-estrogen resistance in breast cancer cell lines. May also be regulated by cellular adhesion to extracellular matrix proteins. Breast tumors are initially dependent on estrogens for growth and progression and can be inhibited by anti-estrogens such as tamoxifen. However, breast cancers progress to become anti-estrogen resistant. Breast cancer anti-estrogen resistance gene 3 was identified in the search for genes involved in the development of estrogen resistance. The gene encodes a component of intracellular signal transduction that causes estrogen-independent proliferation in human breast cancer cells. The protein contains a putative src homology 2 (SH2) domain, a hall mark of cellular tyrosine kinase signaling molecules, and is partly homologous to the cell division cycle protein CDC48. Multiple t ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000260502
  • ENSP00000260502
  • ENSG00000137936
  • ENST00000370243
  • ENSP00000359263
  • ENST00000370244
  • ENSP00000359264
  • ENST00000370247
  • ENSP00000359267
  • ENST00000539242
  • ENSP00000441343

Symbol
  • NSP2
  • SH2D3B
  • NSP2
  • AND-34
  • SH2D3B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.88
transcription factor binding site profile
0.85
gene perturbation
0.71
PubMedID
0.71
tissue sample
0.69


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.47   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 140   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.47   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 140   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
2
1
2
69.6
myeloid white cell count
1
1
1
59
balding measurement
1
1
1
51.2
systolic blood pressure
1
1
1
35.6
glomerular filtration rate
2
1
2
30.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
2
69.6
myeloid white cell count
1
59
balding measurement
1
51.2
systolic blood pressure
1
35.6
glomerular filtration rate
2
30.4
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
BCAR3, NSP family adaptor protein
VGNC:49009
457032
Mouse
MGI:1352501
29815
Rat
RGD:1311688
310838
Dog
BCAR3, NSP family adaptor protein
VGNC:49077
479941
Horse
BCAR3, NSP family adaptor protein
VGNC:50447
100059015
Species
Name
OMA
EggNOG
Inparanoid
Chimp
BCAR3, NSP family adaptor protein
Mouse
Rat
Dog
BCAR3, NSP family adaptor protein
Horse
BCAR3, NSP family adaptor protein
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Gene Ontology Terms (6)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (38)
1 – 10 of 38
BCAR1
Tbio
Novelty: 0.00329214
p_int: 1
Score: 0.983
Data Source: BioPlex,STRINGDB
NEDD9
Tbio
Novelty: 0.00539079
p_int: 0.999999933
p_ni: 2.9e-8
p_wrong: 3.8e-8
Score: 0.924
Data Source: BioPlex,STRINGDB
GAST
Tbio
Novelty: 0.00011795
p_int: 0.999999408
p_ni: 5.86e-7
p_wrong: 6e-9
Score: 0.19
Data Source: BioPlex,STRINGDB
DEFA5
Tbio
Novelty: 0.00863727
p_int: 0.996625584
p_ni: 1.16e-7
p_wrong: 0.0033743
Data Source: BioPlex
CDC42
Tchem
Family: Enzyme
Novelty: 0.00032619
Score: 0.932
Data Source: STRINGDB
TULP4
Tbio
Family: TF
Novelty: 0.05658032
Score: 0.69
Data Source: STRINGDB
KCNE4
Tbio
Family: IC
Novelty: 0.04524673
Score: 0.673
Data Source: STRINGDB
SAT1
Tbio
Family: Enzyme
Novelty: 0.0022456
Score: 0.642
Data Source: STRINGDB
CASS4
Tbio
Novelty: 0.01000437
Score: 0.64
Data Source: STRINGDB
VCP
Tchem
Family: Enzyme
Novelty: 0.00103317
Score: 0.632
Data Source: STRINGDB
Publication Statistics
PubMed Score  26.47

PubMed score by year
PubTator Score  15.89

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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