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Tbio
CAPN15
Calpain-15

Protein Summary
Description
This gene encodes a protein containing zinc-finger-like repeats and a calpain-like protease domain. The encoded protein may function as a transcription factor, RNA-binding protein, or in protein-protein interactions during visual system development. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000219611
  • ENSP00000219611
  • ENSG00000103326

Symbol
  • SOLH
  • SOLH
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.91
histone modification site profile
0.76
tissue
0.69
cell type or tissue
0.67
tissue sample
0.66


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 97.02   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 69   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 97.02   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 69   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
1
1
51.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
51.8
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
calpain 15
695881
Mouse
MGI:1355075
50817
Rat
RGD:1306514
303000
Dog
calpain 15
VGNC:38703
490097
Horse
calpain 15 [Source:HGNC Symbol;Acc:HGNC:11182]
Species
Name
OMA
EggNOG
Inparanoid
Macaque
calpain 15
Mouse
Rat
Dog
calpain 15
Horse
calpain 15 [Source:HGNC Symbol;Acc:HGNC:11182]
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O75808-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (2)
Degradation of the extracellular matrix (R-HSA-1474228)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Degradation of the extracellular matrix
Reactome
Extracellular matrix organization
Name
Explore in Pharos
Explore in Source
Degradation of the extracellular matrix
Extracellular matrix organization
Gene Ontology Terms (7)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (62)
1 – 10 of 62
HERPUD1
Tbio
Novelty: 0.00793854
p_int: 0.999954222
p_ni: 0.000045778
Score: 0.537
Data Source: BioPlex,STRINGDB
CTLA4
Tclin
Novelty: 0.00012781
p_int: 0.999591501
p_ni: 0.000401878
p_wrong: 0.000006621
Data Source: BioPlex
UNC119
Tchem
Novelty: 0.00396292
p_int: 0.999476335
p_ni: 0.000517528
p_wrong: 0.000006137
Score: 0.164
Data Source: BioPlex,STRINGDB
FAM189B
Tbio
Novelty: 0.21064304
p_int: 0.999474634
p_ni: 0.000525366
Data Source: BioPlex
TBL1Y
Tbio
p_int: 0.999441635
p_ni: 0.000558358
p_wrong: 7e-9
Data Source: BioPlex
FNDC5
Tbio
Novelty: 0.0015827
p_int: 0.998804046
p_ni: 0.001195954
Score: 0.187
Data Source: BioPlex,STRINGDB
RNF126
Tbio
Family: Enzyme
Novelty: 0.08123801
p_int: 0.998647221
p_ni: 0.00135277
p_wrong: 8e-9
Score: 0.254
Data Source: BioPlex,STRINGDB
FAM189A2
Tdark
Novelty: 0.41335428
p_int: 0.998527102
p_ni: 0.001472875
p_wrong: 2.3e-8
Data Source: BioPlex
CDH5
Tbio
Novelty: 0.00072649
p_int: 0.991171742
p_ni: 0.008788144
p_wrong: 0.000040113
Score: 0.178
Data Source: BioPlex,STRINGDB
CAPNS1
Tbio
Novelty: 0.00954566
Score: 0.966
Data Source: STRINGDB
Publication Statistics
PubMed Score  97.02

PubMed score by year
PubTator Score  5.33

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer