PPP1R15A
Protein phosphatase 1 regulatory subunit 15A
You are using an outdated browser. Please upgrade your browser to improve your experience.
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
small molecule perturbation | 0.95 | ||
biological process | 0.91 | ||
transcription factor binding site profile | 0.88 | ||
virus perturbation | 0.88 | ||
gene perturbation | 0.87 | ||
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
- OR - satisfy the following criterion:
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Target has at least one approved drug - AND - satisfies the preceding conditions
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Downregulation of TGF-beta receptor signaling | ||||
Reactome | Signal Transduction | ||||
Reactome | Signaling by TGF-beta Receptor Complex | ||||
Reactome | Signaling by TGF-beta family members | ||||
Reactome | TGF-beta receptor signaling activates SMADs | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Downregulation of TGF-beta receptor signaling | ||||
Signal Transduction | ||||
Signaling by TGF-beta Receptor Complex | ||||
Signaling by TGF-beta family members | ||||
TGF-beta receptor signaling activates SMADs | ||||
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | ParkinsonsUK-UCL | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred by Curator (IC) | ParkinsonsUK-UCL | |||
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
reticulocyte measurement | 3 | 5 | 6 | 96.1 | |||||
red blood cell distribution width | 4 | 3 | 5 | 95.1 | |||||
reticulocyte count | 6 | 4 | 12 | 94.4 | |||||
eosinophil count | 3 | 1 | 3 | 70.9 | |||||
mean corpuscular hemoglobin concentration | 1 | 1 | 1 | 64.4 | |||||
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
reticulocyte measurement | 6 | 96.1 | |||||
red blood cell distribution width | 5 | 95.1 | |||||
reticulocyte count | 12 | 94.4 | |||||
eosinophil count | 3 | 70.9 | |||||
mean corpuscular hemoglobin concentration | 1 | 64.4 | |||||
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | protein phosphatase 1 regulatory subunit 15A | VGNC:12063 | 456191 | |||||
Macaque | protein phosphatase 1 regulatory subunit 15A | 718350 | ||||||
Mouse | MGI:1927072 | 17872 | ||||||
Rat | RGD:621526 | 171071 | ||||||
Dog | protein phosphatase 1 regulatory subunit 15A | VGNC:53754 | 476419 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | protein phosphatase 1 regulatory subunit 15A | |||||
Macaque | protein phosphatase 1 regulatory subunit 15A | |||||
Mouse | ||||||
Rat | ||||||
Dog | protein phosphatase 1 regulatory subunit 15A | |||||
PMID | Year | Title |
---|