Tbio RNASEH2A Ribonuclease H2 subunit A

Protein Summary

Description

Catalytic subunit of RNase HII, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes. The protein encoded by this gene is a component of the heterotrimeric type II ribonuclease H enzyme (RNAseH2). RNAseH2 is the major source of ribonuclease H activity in mammalian cells and endonucleolytically cleaves ribonucleotides. It is predicted to remove Okazaki fragment RNA primers during lagging strand DNA synthesis and to excise single ribonucleotides from DNA-DNA duplexes. Mutations in this gene cause Aicardi-Goutieres Syndrome (AGS), a an autosomal recessive neurological disorder characterized by progressive microcephaly and psychomotor retardation, intracranial calcifications, elevated levels of interferon-alpha and white blood cells in the cerebrospinal fluid.[provided by RefSeq, Aug 2009]

Uniprot Accession IDs

• O75792
• B2RCY1
• Q96F11
• RNase H2 subunit A

Gene Name

• RNASEH2A

Ensembl ID

• ENST00000221486
• ENSP00000221486
• ENSG00000104889

Symbol

• RNASEHI
• RNHIA
• AGS4
• JUNB
• RNHL
• RNHIA
• THSD8
• RNASEHI

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.8
disease perturbation	0.74
protein domain	0.73
transcription factor binding site profile	0.72
PubMedID	0.7

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Nuclease / Endoribonuclease / Ribonuclease H2 Subunit A

Protein / Nucleic Acid Binding / Rna Binding Protein / Endoribonuclease / Ribonuclease H2 Subunit A

Protein / Hydrolase / Ribonuclease H2 Subunit A

DTO Classes

Protein / Enzyme / Nuclease / Endoribonuclease / Ribonuclease H2 Subunit A

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 242.14   (req: < 5)

Gene RIFs: 17   (req: <= 3)

Antibodies: 167   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 242.14   (req: >= 5)

Gene RIFs: 17   (req: > 3)

Antibodies: 167   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0