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Tbio
RNASEH2A
Ribonuclease H2 subunit A

Protein Summary
Description
Catalytic subunit of RNase HII, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes. The protein encoded by this gene is a component of the heterotrimeric type II ribonuclease H enzyme (RNAseH2). RNAseH2 is the major source of ribonuclease H activity in mammalian cells and endonucleolytically cleaves ribonucleotides. It is predicted to remove Okazaki fragment RNA primers during lagging strand DNA synthesis and to excise single ribonucleotides from DNA-DNA duplexes. Mutations in this gene cause Aicardi-Goutieres Syndrome (AGS), a an autosomal recessive neurological disorder characterized by progressive microcephaly and psychomotor retardation, intracranial calcifications, elevated levels of interferon-alpha and white blood cells in the cerebrospinal fluid.[provide ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000221486
  • ENSP00000221486
  • ENSG00000104889

Symbol
  • RNASEHI
  • RNHIA
  • AGS4
  • JUNB
  • RNHL
  • RNHIA
  • THSD8
  • RNASEHI
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.8
disease perturbation
0.74
protein domain
0.73
transcription factor binding site profile
0.72
PubMedID
0.7


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 218.49   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 167   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 218.49   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 167   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (199)
RNASEH2C
Tbio
Family:  Enzyme
Novelty:  0.06148299
p_int:  0.999999736
p_ni:  2.64e-7
Score:  0.999
Data Source:  BioPlex,STRINGDB
FAM136A
Tdark
Novelty:  0.4050275
p_int:  0.999665604
p_ni:  0.000334396
Score:  0.223
Data Source:  BioPlex,STRINGDB
KPTN
Tbio
Novelty:  0.06841936
p_int:  0.997850982
p_ni:  0.002149018
Score:  0.173
Data Source:  BioPlex,STRINGDB
C6orf141
Tdark
Novelty:  1.46022784
p_int:  0.987857785
p_ni:  0.012142215
Data Source:  BioPlex
AGPAT1
Tbio
Family:  Enzyme
Novelty:  0.05245441
p_int:  0.980864772
p_ni:  0.019135227
Score:  0.383
Data Source:  BioPlex,STRINGDB
BPNT1
Tbio
Family:  Enzyme
Novelty:  0.1114547
p_int:  0.980804465
p_ni:  0.019195535
Data Source:  BioPlex
KLHL1
Tbio
Novelty:  0.05206893
p_int:  0.830861214
p_ni:  0.16913864
p_wrong:  1.47e-7
Data Source:  BioPlex
RNASEH2B
Tbio
Family:  Enzyme
Novelty:  0.02210045
Score:  0.999
Data Source:  STRINGDB
FEN1
Tchem
Family:  Enzyme
Novelty:  0.00082515
Score:  0.955
Data Source:  STRINGDB
RNASEH1
Tchem
Family:  Enzyme
Novelty:  0.01838314
Score:  0.948
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (20)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
4
6
6
98.2
reticulocyte measurement
3
5
6
97.9
mean corpuscular hemoglobin concentration
3
3
3
97
reticulocyte count
7
4
8
96.5
erythrocyte count
3
4
4
95.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
6
98.2
reticulocyte measurement
6
97.9
mean corpuscular hemoglobin concentration
3
97
reticulocyte count
8
96.5
erythrocyte count
4
95.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ribonuclease H2 subunit A
VGNC:7490
455752
Macaque
ribonuclease H2 subunit A
716701
Mouse
MGI:1916974
69724
Rat
RGD:1307248
364974
Dog
ribonuclease H2 subunit A
VGNC:45612
100856442
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ribonuclease H2 subunit A
Macaque
ribonuclease H2 subunit A
Mouse
Rat
Dog
ribonuclease H2 subunit A
Publication Statistics
PubMed Score 218.49
PubMed score by year
PubTator Score 14.60
PubTator score by year
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Related Publications
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PMID
Year
Title