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Tbio
GRAP2
GRB2-related adapter protein 2

Protein Summary
Description
Interacts with SLP-76 to regulate NF-AT activation. Binds to tyrosine-phosphorylated shc. This gene encodes a member of the GRB2/Sem5/Drk family. This member is an adaptor-like protein involved in leukocyte-specific protein-tyrosine kinase signaling. Like its related family member, GRB2-related adaptor protein (GRAP), this protein contains an SH2 domain flanked by two SH3 domains. This protein interacts with other proteins, such as GRB2-associated binding protein 1 (GAB1) and the SLP-76 leukocyte protein (LCP2), through its SH3 domains. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Apr 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000344138
  • ENSP00000339186
  • ENSG00000100351
  • ENST00000407075
  • ENSP00000385607

Symbol
  • GADS
  • GRB2L
  • GRID
  • P38
  • GADS
  • GRID
  • GRPL
  • GrbX
  • Mona
  • GRB2L
  • GRBLG
  • Grf40
  • GRAP-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.66
transcription factor
0.64
interacting protein
0.61
tissue
0.6
cell type or tissue
0.56


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 179.58   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 458   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 179.58   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 458   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (226)
USP8
Tchem
Family:  Enzyme
Novelty:  0.0105645
p_int:  1
Score:  0.554
Data Source:  BioPlex,STRINGDB
GAB2
Tbio
Novelty:  0.00697372
p_int:  0.999999997
p_ni:  1e-9
p_wrong:  2e-9
Score:  0.898
Data Source:  BioPlex,STRINGDB
PTPN23
Tbio
Family:  Enzyme
Novelty:  0.03578001
p_int:  0.999999991
p_ni:  7e-9
p_wrong:  2e-9
Score:  0.635
Data Source:  BioPlex,STRINGDB
STAMBP
Tchem
Novelty:  0.01543821
p_int:  0.999999835
p_ni:  1.61e-7
p_wrong:  4e-9
Score:  0.354
Data Source:  BioPlex,STRINGDB
GAREM1
Tbio
Novelty:  0.21021078
p_int:  0.999999529
p_ni:  4.71e-7
Score:  0.453
Data Source:  BioPlex,STRINGDB
GAB1
Tchem
Novelty:  0.02174353
p_int:  0.999998408
p_ni:  0.000001588
p_wrong:  4e-9
Score:  0.722
Data Source:  BioPlex,STRINGDB
ZSCAN21
Tbio
Family:  TF
Novelty:  0.18025344
p_int:  0.999996925
p_ni:  0.000003075
Score:  0.209
Data Source:  BioPlex,STRINGDB
CDC27
Tbio
Novelty:  0.00589846
p_int:  0.999922559
p_ni:  0.000077441
Data Source:  BioPlex
TNIP1
Tbio
Novelty:  0.0147254
p_int:  0.999921754
p_ni:  0.000078246
Score:  0.196
Data Source:  BioPlex,STRINGDB
IFNAR2
Tclin
Novelty:  0.00453303
p_int:  0.9994602
p_ni:  0.0005398
Score:  0.307
Data Source:  BioPlex,STRINGDB
Pathways (31)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
CD28 co-stimulation
Reactome
Costimulation by the CD28 family
Reactome
DAP12 interactions
Reactome
DAP12 signaling
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
CD28 co-stimulation
Costimulation by the CD28 family
DAP12 interactions
DAP12 signaling
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
1
1
1
59.8
eosinophil percentage of leukocytes
1
1
1
6.6
1
1
0
1.1
4.6
1
1
0
1.1
1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
1
59.8
eosinophil percentage of leukocytes
1
6.6
0
1.1
4.6
0
1.1
1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
GRB2 related adaptor protein 2
VGNC:53398
744653
Macaque
GRB2-related adaptor protein 2
704410
Mouse
MGI:1333842
17444
Dog
GRB2 related adaptor protein 2
VGNC:41470
481241
Horse
GRB2 related adaptor protein 2
VGNC:18568
100055418
Species
Name
OMA
EggNOG
Inparanoid
Chimp
GRB2 related adaptor protein 2
Macaque
GRB2-related adaptor protein 2
Mouse
Dog
GRB2 related adaptor protein 2
Horse
GRB2 related adaptor protein 2
Publication Statistics
PubMed Score 179.58
PubMed score by year
PubTator Score 281.76
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title