GRAP2
GRB2-related adapter protein 2
Protein Summary
Interacts with SLP-76 to regulate NF-AT activation. Binds to tyrosine-phosphorylated shc. This gene encodes a member of the GRB2/Sem5/Drk family. This member is an adaptor-like protein involved in leukocyte-specific protein-tyrosine kinase signaling. Like its related family member, GRB2-related adaptor protein (GRAP), this protein contains an SH2 domain flanked by two SH3 domains. This protein interacts with other proteins, such as GRB2-associated binding protein 1 (GAB1) and the SLP-76 leukocyte protein (LCP2), through its SH3 domains. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Apr 2014]
- ENST00000344138
- ENSP00000339186
- ENSG00000100351
- ENST00000407075
- ENSP00000385607
- GADS
- GRB2L
- GRID
- P38
- GADS
- GRID
- GRPL
- GrbX
- Mona
- GRB2L
- GRBLG
- Grf40
- GRAP-2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
tissue sample | 0.66 | ||
transcription factor | 0.64 | ||
interacting protein | 0.61 | ||
tissue | 0.6 | ||
cell type or tissue | 0.56 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 262.46 (req: < 5)
Gene RIFs: 17 (req: <= 3)
Antibodies: 458 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 262.46 (req: >= 5)
Gene RIFs: 17 (req: > 3)
Antibodies: 458 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0