Protein Summary
Functions as a renin and prorenin cellular receptor. May mediate renin-dependent cellular responses by activating ERK1 and ERK2. By increasing the catalytic efficiency of renin in AGT/angiotensinogen conversion to angiotensin I, it may also play a role in the renin-angiotensin system (RAS). This gene encodes a protein that is associated with adenosine triphosphatases (ATPases). Proton-translocating ATPases have fundamental roles in energy conservation, secondary active transport, acidification of intracellular compartments, and cellular pH homeostasis. There are three classes of ATPases- F, P, and V. The vacuolar (V-type) ATPases have a transmembrane proton-conducting sector and an extramembrane catalytic sector. The encoded protein has been found associated with the transmembrane sector of the V-type ATPases. [provided by RefSeq, Jul 2008]
- ENST00000636409
- ENSP00000489819
- ENSG00000182220
- ENST00000636580
- ENSP00000490083
- ATP6IP2
- CAPER
- ELDF10
- PRR
- M8-9
- MRXE
- RENR
- XMRE
- XPDS
- HT028
- MRXSH
- ELDF10
- ATP6IP2
- MSTP009
- APT6M8-9
- ATP6M8-9
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
kinase perturbation | 0.95 | ||
disease perturbation | 0.9 | ||
histone modification site profile | 0.86 | ||
tissue | 0.82 | ||
cellular component | 0.65 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 281.17 (req: < 5)
Gene RIFs: 99 (req: <= 3)
Antibodies: 322 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 281.17 (req: >= 5)
Gene RIFs: 99 (req: > 3)
Antibodies: 322 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 10
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0