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Tbio
ATP6AP2
Renin receptor

Protein Classes
Protein Summary
Description
Functions as a renin and prorenin cellular receptor. May mediate renin-dependent cellular responses by activating ERK1 and ERK2. By increasing the catalytic efficiency of renin in AGT/angiotensinogen conversion to angiotensin I, it may also play a role in the renin-angiotensin system (RAS). This gene encodes a protein that is associated with adenosine triphosphatases (ATPases). Proton-translocating ATPases have fundamental roles in energy conservation, secondary active transport, acidification of intracellular compartments, and cellular pH homeostasis. There are three classes of ATPases- F, P, and V. The vacuolar (V-type) ATPases have a transmembrane proton-conducting sector and an extramembrane catalytic sector. The encoded protein has been found associated with the transmembrane sector of the V-type ATPases. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000636409
  • ENSP00000489819
  • ENSG00000182220
  • ENST00000636580
  • ENSP00000490083

Symbol
  • ATP6IP2
  • CAPER
  • ELDF10
  • PRR
  • M8-9
  • MRXE
  • RENR
  • XMRE
  • XPDS
  • HT028
  • MRXSH
  • ELDF10
  • ATP6IP2
  • MSTP009
  • APT6M8-9
  • ATP6M8-9
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.95
disease perturbation
0.9
histone modification site profile
0.86
tissue
0.82
cellular component
0.65


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 250.07   (req: < 5)
Gene RIFs: 68   (req: <= 3)
Antibodies: 322   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 250.07   (req: >= 5)
Gene RIFs: 68   (req: > 3)
Antibodies: 322   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ATPase H+ transporting accessory protein 2
VGNC:12199
465575
Macaque
ATPase H+ transporting accessory protein 2
705048
Mouse
MGI:1917745
70495
Rat
RGD:1561269
302526
Dog
ATPase H+ transporting accessory protein 2
VGNC:38267
100682978
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ATPase H+ transporting accessory protein 2
Macaque
ATPase H+ transporting accessory protein 2
Mouse
Rat
Dog
ATPase H+ transporting accessory protein 2
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O75787-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (69)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Metabolism of Angiotensinogen to Angiotensins
Reactome
Metabolism of proteins
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Metabolism of Angiotensinogen to Angiotensins
Metabolism of proteins
Neutrophil degranulation
Gene Ontology Terms (18)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (159)
1 – 10 of 159
PICK1
Tbio
Novelty: 0.0058265
p_int: 0.999999987
p_ni: 1.3e-8
Score: 0.177
Data Source: BioPlex,STRINGDB
TMEM199
Tbio
Novelty: 0.05799147
p_int: 0.999996004
p_ni: 0.000003996
Score: 0.927
Data Source: BioPlex,STRINGDB
VMA21
Tdark
Family: Enzyme
Novelty: 0.46129032
p_int: 0.99999589
p_ni: 0.000004106
p_wrong: 4e-9
Score: 0.901
Data Source: BioPlex,STRINGDB
ATP6V0A2
Tbio
Family: Enzyme
Novelty: 0.00504614
p_int: 0.999988373
p_ni: 0.000011627
Score: 0.928
Data Source: BioPlex,STRINGDB
TCIRG1
Tbio
Family: Enzyme
Novelty: 0.00814253
p_int: 0.999542202
p_ni: 0.000457798
Score: 0.931
Data Source: BioPlex,STRINGDB
CCDC115
Tbio
Novelty: 0.23966137
p_int: 0.999216923
p_ni: 0.000614604
p_wrong: 0.000168473
Score: 0.845
Data Source: BioPlex,STRINGDB
ATP6V0A1
Tbio
Family: Enzyme
Novelty: 0.02009317
p_int: 0.999035882
p_ni: 0.000964117
Score: 0.852
Data Source: BioPlex,STRINGDB
ATP6V1D
Tbio
Family: Enzyme
Novelty: 0.02298626
p_int: 0.997995792
p_ni: 0.002004208
Score: 0.749
Data Source: BioPlex,STRINGDB
ATP6V1C1
Tbio
Family: Enzyme
Novelty: 0.03660846
p_int: 0.99707179
p_ni: 0.00292821
Score: 0.864
Data Source: BioPlex,STRINGDB
ATP6V0C
Tbio
Family: Enzyme
Novelty: 0.01142874
p_int: 0.995532306
p_ni: 0.004467694
Score: 0.993
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  250.07

PubMed score by year
PubTator Score  206.57

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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