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Tbio
RAD51D
DNA repair protein RAD51 homolog 4

Protein Summary
Description
Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. Bind to single-stranded DNA (ssDNA) and has DNA-dependent ATPase activity. Part of the Rad21 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. Involved in telomere maintenance. The BCDX2 subcomplex XRCC2:RAD51D can stimulate Holliday junction resolution by BLM. The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, which ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000335858
  • ENSP00000338408
  • ENSG00000185379
  • ENST00000345365
  • ENSP00000338790
  • ENST00000394589
  • ENSP00000378090
  • ENST00000586044
  • ENSP00000465584
  • ENST00000587977
  • ENSP00000466587
  • ENST00000588594
  • ENSP00000465366
  • ENST00000590016
  • ENSP00000466399

Symbol
  • RAD51L3
  • TRAD
  • R51H3
  • BROVCA4
  • RAD51L3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
molecular function
0.99
kinase perturbation
0.84
cell type or tissue
0.75
cellular component
0.75


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.39   (req: < 5)
Gene RIFs: 26   (req: <= 3)
Antibodies: 330   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.39   (req: >= 5)
Gene RIFs: 26   (req: > 3)
Antibodies: 330   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
QT interval
2
1
0
1.2
57.8
electrocardiography
1
1
17
40.7
TPE interval measurement
1
1
1
21.5
macrophage inflammatory protein 1b measurement
1
1
1
13.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
QT interval
0
1.2
57.8
electrocardiography
17
40.7
TPE interval measurement
1
21.5
macrophage inflammatory protein 1b measurement
1
13.5
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RAD51 paralog D
VGNC:9550
468212
Mouse
MGI:1261809
19364
Rat
RGD:1306944
303375
Dog
RAD51 paralog D
VGNC:45320
491143
Horse
RAD51 paralog D [Source:HGNC Symbol;Acc:HGNC:9823]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RAD51 paralog D
Mouse
Rat
Dog
RAD51 paralog D
Horse
RAD51 paralog D [Source:HGNC Symbol;Acc:HGNC:9823]
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O75771-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (16)
DNA Double-Strand Break Repair (R-HSA-5693532)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
DNA Double-Strand Break Repair
Reactome
DNA Repair
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
HDR through Homologous Recombination (HRR)
Name
Explore in Pharos
Explore in Source
DNA Double-Strand Break Repair
DNA Repair
Gene expression (Transcription)
Generic Transcription Pathway
HDR through Homologous Recombination (HRR)
Protein-Protein Interactions (158)
1 – 10 of 158
XRCC2
Tbio
Novelty:  0.00862049
p_int:  0.999992702
p_ni:  0.000007293
p_wrong:  5e-9
Score:  0.99
Data Source:  BioPlex,Reactome,STRINGDB
DKKL1
Tbio
Novelty:  0.00544618
p_int:  0.99646458
p_ni:  0.003535419
Data Source:  BioPlex
CCL22
Tbio
Novelty:  0.00245992
p_int:  0.987301684
p_ni:  0.012698313
p_wrong:  3e-9
Data Source:  BioPlex
NDUFAF5
Tbio
Family:  Enzyme
Novelty:  0.13483499
p_int:  0.985991184
p_ni:  0.013944938
p_wrong:  0.000063878
Data Source:  BioPlex
ICMT
Tchem
Family:  Enzyme
Novelty:  0.00706181
p_int:  0.982396043
p_ni:  0.017603957
Score:  0.193
Data Source:  BioPlex,STRINGDB
ARL4C
Tbio
Family:  Enzyme
Novelty:  0.04764628
p_int:  0.978096232
p_ni:  0.021832816
p_wrong:  0.000070951
Data Source:  BioPlex
TOMM22
Tbio
Novelty:  0.01217913
p_int:  0.918866888
p_ni:  0.029028698
p_wrong:  0.052104415
Data Source:  BioPlex
LAGE3
Tdark
Novelty:  0.02099961
p_int:  0.917334557
p_ni:  0.071164127
p_wrong:  0.011501316
Data Source:  BioPlex
WDR19
Tbio
Novelty:  0.037197
p_int:  0.898653438
p_ni:  0.101346562
Data Source:  BioPlex
BRIP1
Tbio
Novelty:  0.03886334
p_int:  0.896942907
p_ni:  0.103052469
p_wrong:  0.000004624
Score:  0.476
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  57.39

PubMed score by year
PubTator Score  144.48

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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