Tbio RAD51D DNA repair protein RAD51 homolog 4

Protein Summary

Description

Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. Bind to single-stranded DNA (ssDNA) and has DNA-dependent ATPase activity. Part of the Rad21 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. Involved in telomere maintenance. The BCDX2 subcomplex XRCC2:RAD51D can stimulate Holliday junction resolution by BLM. The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, which are known to be involved in the homologous recombination and repair of DNA. This protein forms a complex with several other members of the RAD51 family, including RAD51L1, RAD51L2, and XRCC2. The protein complex formed with this protein has been shown to catalyze homologous pairing between single- and double-stranded DNA, and is thought to play a role in the early stage of recombinational repair of DNA. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream ring finger and FYVE-like domain containing 1 (RFFL) gene. [provided by RefSeq, Jan 2011]

Uniprot Accession IDs

• O75771
• B4DJU7
• E1P637
• O43537
• O60355
• O75196
• O75847
• O75848
• O76073
• O76085
• O94908
• Q9UFU5

Gene Name

• RAD51D

Ensembl ID

• ENST00000335858
• ENSP00000338408
• ENSG00000185379
• ENST00000345365
• ENSP00000338790
• ENST00000394589
• ENSP00000378090
• ENST00000586044
• ENSP00000465584
• ENST00000587977
• ENSP00000466587
• ENST00000588594
• ENSP00000465366
• ENST00000590016
• ENSP00000466399

Symbol

• RAD51L3
• TRAD
• R51H3
• BROVCA4
• RAD51L3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
co-expressed gene	1
molecular function	0.99
kinase perturbation	0.84
cell type or tissue	0.75
cellular component	0.75

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 75.02   (req: < 5)

Gene RIFs: 43   (req: <= 3)

Antibodies: 330   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 75.02   (req: >= 5)

Gene RIFs: 43   (req: > 3)

Antibodies: 330   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0