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Tbio
B3GALNT1
UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1

Protein Summary
Description
Transfers N-acetylgalactosamine onto globotriaosylceramide (PubMed:10993897). Plays a critical role in preimplantation stage embryonic development (By similarity). This gene is a member of the beta-1,3-galactosyltransferase (beta3GalT) gene family. This family encodes type II membrane-bound glycoproteins with diverse enzymatic functions using different donor substrates (UDP-galactose and UDP-N-acetylglucosamine) and different acceptor sugars (N-acetylglucosamine, galactose, N-acetylgalactosamine). The beta3GalT genes are distantly related to the Drosophila Brainiac gene and have the protein coding sequence contained in a single exon. The beta3GalT proteins also contain conserved sequences not found in the beta4GalT or alpha3GalT proteins. The carbohydrate chains synthesized by these enzymes are designated as type 1, whereas beta4GalT enzymes synthesize type 2 carbohydrate chains. The ratio of type 1:type 2 chains changes during embryogenesis. By sequence similarity, the beta3GalT genes ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000320474
  • ENSP00000323479
  • ENSG00000169255
  • ENST00000392779
  • ENSP00000376530
  • ENST00000392781
  • ENSP00000376532
  • ENST00000473285
  • ENSP00000418226
  • ENST00000488170
  • ENSP00000420163

Symbol
  • B3GALT3
  • P
  • P1
  • GLOB
  • GLCT3
  • galT3
  • Gb4Cer
  • B3GALT3
  • beta3Gal-T3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.88
PubMedID
0.8
histone modification site profile
0.73
gene perturbation
0.66
kinase perturbation
0.66


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 80.13   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 88   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 80.13   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 88   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (77)
CST1
Tbio
Novelty:  0.02399609
p_int:  0.998864747
p_ni:  0.001087903
p_wrong:  0.00004735
Data Source:  BioPlex
AMY1A
Tchem
Family:  Enzyme
Novelty:  0.00210045
p_int:  0.998843885
p_ni:  0.001156115
Data Source:  BioPlex
DUSP14
Tbio
Family:  Enzyme
Novelty:  0.04013065
p_int:  0.998807996
p_ni:  0.001192003
Data Source:  BioPlex
KPRP
Tdark
Novelty:  0.11744927
p_int:  0.99548986
p_ni:  0.00451014
Data Source:  BioPlex
SELENBP1
Tbio
Novelty:  0.00758018
p_int:  0.990196949
p_ni:  0.009803051
Data Source:  BioPlex
RNASE7
Tbio
Family:  Enzyme
Novelty:  0.01866347
p_int:  0.988188248
p_ni:  0.011811747
p_wrong:  5e-9
Data Source:  BioPlex
DSG4
Tbio
Novelty:  0.01599371
p_int:  0.984751825
p_ni:  0.015230128
p_wrong:  0.000018047
Data Source:  BioPlex
PKP3
Tbio
Novelty:  0.0269462
p_int:  0.984679468
p_ni:  0.015320526
p_wrong:  6e-9
Data Source:  BioPlex
LOR
Tbio
Novelty:  0.0033781
p_int:  0.972346378
p_ni:  0.02725486
p_wrong:  0.000398762
Score:  0.217
Data Source:  BioPlex,STRINGDB
LRRC15
Tbio
Novelty:  0.03701624
p_int:  0.969290477
p_ni:  0.030709523
Data Source:  BioPlex
Pathways (14)
Glycosphingolipid metabolism (R-HSA-1660662)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glycosphingolipid metabolism
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Sphingolipid metabolism
Name
Explore in Pharos
Explore in Source
Glycosphingolipid metabolism
Metabolism
Metabolism of lipids
Sphingolipid metabolism
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (11)
Find Similar Targets
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
2
3
1
1
80.2
self reported educational attainment
3
3
3
44
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
1
1
80.2
self reported educational attainment
3
44
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group)
703939
Mouse
MGI:1349405
26879
Rat
RGD:1304797
310508
Dog
beta-1,3-N-acetylgalactosaminyltransferase 1
VGNC:53548
100683634
Horse
beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group) [Source:HGNC Symbol;Acc:HGNC:918]
Species
Name
OMA
EggNOG
Inparanoid
Macaque
beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group)
Mouse
Rat
Dog
beta-1,3-N-acetylgalactosaminyltransferase 1
Horse
beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group) [Source:HGNC Symbol;Acc:HGNC:918]
Publication Statistics
PubMed Score 80.13
PubMed score by year
PubTator Score 76.24
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title