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Tchem
SLC22A3
Solute carrier family 22 member 3

Protein Summary
Description
Mediates potential-dependent transport of a variety of organic cations. May play a significant role in the disposition of cationic neurotoxins and neurotransmitters in the brain. Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000275300
  • ENSP00000275300
  • ENSG00000146477

Symbol
  • EMTH
  • OCT3
  • EMT
  • EMTH
  • OCT3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug
0.93
trait
0.86
disease
0.84
chemical
0.82
molecular function
0.73


Related Tools
RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 182.19   (req: < 5)
Gene RIFs: 46   (req: <= 3)
Antibodies: 190   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 182.19   (req: >= 5)
Gene RIFs: 46   (req: > 3)
Antibodies: 190   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
chlorhexidine
chemical structure image
Active Ligands (1)
1 – 1 of 1
disprocynium24
chemical structure image
GWAS Traits (19)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
6
3
6
99.6
lipoprotein A measurement
2
8
0
8.4
99.6
prostate carcinoma
6
4
0
1.1
98.7
apolipoprotein A 1 measurement
1
4
0
8.4
98.7
3
3
2
1
93.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
6
99.6
lipoprotein A measurement
0
8.4
99.6
prostate carcinoma
0
1.1
98.7
apolipoprotein A 1 measurement
0
8.4
98.7
2
1
93.9
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 22 member 3
VGNC:7920
463114
Macaque
solute carrier family 22 member 3
709454
Mouse
MGI:1333817
20519
Rat
RGD:3701
29504
Dog
solute carrier family 22 member 3
VGNC:46278
476261
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 22 member 3
Macaque
solute carrier family 22 member 3
Mouse
Rat
Dog
solute carrier family 22 member 3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O75751-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (10)
Abacavir transmembrane transport (R-HSA-2161517)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Abacavir transmembrane transport
Reactome
Abacavir transport and metabolism
Reactome
Metabolism
Reactome
Organic cation transport
Reactome
Organic cation/anion/zwitterion transport
Name
Explore in Pharos
Explore in Source
Abacavir transmembrane transport
Abacavir transport and metabolism
Metabolism
Organic cation transport
Organic cation/anion/zwitterion transport
Gene Ontology Terms (12)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
MGI
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (52)
1 – 10 of 52
IGF2R
Tchem
Novelty: 0.00138374
Score: 0.729
Data Source: STRINGDB
YRDC
Tdark
Novelty: 0.01240103
Score: 0.71
Data Source: STRINGDB
SLC47A1
Tchem
Family: Transporter
Novelty: 0.00535064
Score: 0.68
Data Source: STRINGDB
SLC47A2
Tchem
Family: Transporter
Novelty: 0.01171254
Score: 0.678
Data Source: STRINGDB
SLC29A4
Tchem
Family: Transporter
Novelty: 0.00772914
Score: 0.678
Data Source: STRINGDB
EHMT2
Tchem
Family: Epigenetic
Novelty: 0.00262578
Score: 0.65
Data Source: STRINGDB
RSC1A1
Tbio
Novelty: 0.23664927
Score: 0.642
Data Source: STRINGDB
GGA3
Tbio
Novelty: 0.01898553
Score: 0.641
Data Source: STRINGDB
CSTF3
Tbio
Novelty: 0.05260909
Score: 0.631
Data Source: STRINGDB
SLC6A2
Tclin
Family: Transporter
Novelty: 0.00093735
Score: 0.625
Data Source: STRINGDB
Publication Statistics
PubMed Score  182.19

PubMed score by year
PubTator Score  92.46

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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