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Tchem
PIK3C2G
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma

Protein Summary
Description
Generates phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) that act as second messengers. May play a role in SDF1A-stimulated chemotaxis (By similarity). The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. This gene may play a role in several diseases, including type II diabetes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000266497
  • ENSP00000266497
  • ENSG00000139144
  • ENST00000433979
  • ENSP00000404845

Symbol
  • PI3K-C2GAMMA
  • PI3K-C2-gamma
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
molecular function
0.96
gene perturbation
0.7
cell line
0.63
small molecule
0.62


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.86   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 108   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.86   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 108   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Dark Kinase Knowledgebase
Thumbnail image for Dark Kinase Knowledgebase
The Dark Kinase Knowledgebase is an an online compendium of knowledge and experimental results of understudied kinases.
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (95)
PTEN
Tchem
Family:  Enzyme
Novelty:  0.00013818
Score:  0.935
Data Source:  STRINGDB
PI4K2B
Tbio
Family:  Enzyme
Novelty:  0.19272599
Score:  0.93
Data Source:  STRINGDB
HRAS
Tchem
Family:  Enzyme
Novelty:  0.00008069
Score:  0.928
Data Source:  STRINGDB
PIKFYVE
Tchem
Family:  Kinase
Novelty:  0.00441336
Score:  0.927
Data Source:  STRINGDB
PI4KB
Tchem
Family:  Kinase
Novelty:  0.00856875
Score:  0.922
Data Source:  STRINGDB
INPP4B
Tbio
Family:  Enzyme
Novelty:  0.02053228
Score:  0.921
Data Source:  STRINGDB
INPPL1
Tchem
Family:  Enzyme
Novelty:  0.00634126
Score:  0.92
Data Source:  STRINGDB
RAC1
Tbio
Family:  Enzyme
Novelty:  0.00365325
Score:  0.917
Data Source:  STRINGDB
PI4KA
Tchem
Family:  Kinase
Novelty:  0.01701469
Score:  0.915
Data Source:  STRINGDB
INPP5F
Tbio
Family:  Enzyme
Novelty:  0.1881586
Score:  0.915
Data Source:  STRINGDB
Nearest Tclin Targets (6)
Explore Nearest Tclin Targets
Pathways (17)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
PI Metabolism
Reactome
Phospholipid metabolism
Reactome
Synthesis of PIPs at the Golgi membrane
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of lipids
PI Metabolism
Phospholipid metabolism
Synthesis of PIPs at the Golgi membrane
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (17)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations ()
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
3
2
3
68.5
alcohol use disorder measurement
1
1
1
21.5
alcohol consumption measurement
1
1
1
21.5
diastolic blood pressure
1
1
0
1.8
15.8
glucose measurement
1
1
1
15.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
3
68.5
alcohol use disorder measurement
1
21.5
alcohol consumption measurement
1
21.5
diastolic blood pressure
0
1.8
15.8
glucose measurement
1
15.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma
VGNC:8607
465321
Macaque
phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma
702929
Mouse
MGI:1203730
18705
Rat
RGD:620231
116720
Dog
phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma
VGNC:44553
477681
Species
Name
OMA
EggNOG
Inparanoid
Chimp
phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma
Macaque
phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma
Mouse
Rat
Dog
phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma
Publication Statistics
PubMed Score 14.86
PubMed score by year
PubTator Score 7.27
PubTator score by year
Patents
Patents by year
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Related Publications
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PMID
Year
Title