PIK3C2G
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma
Protein Summary
Generates phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) that act as second messengers. May play a role in SDF1A-stimulated chemotaxis (By similarity). The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. This gene may play a role in several diseases, including type II diabetes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
- ENST00000266497
- ENSP00000266497
- ENSG00000139144
- ENST00000433979
- ENSP00000404845
- PI3K-C2GAMMA
- PI3K-C2-gamma
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 1 | ||
molecular function | 0.96 | ||
gene perturbation | 0.7 | ||
cell line | 0.63 | ||
small molecule | 0.62 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 14.86 (req: < 5)
Gene RIFs: 5 (req: <= 3)
Antibodies: 108 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 14.86 (req: >= 5)
Gene RIFs: 5 (req: > 3)
Antibodies: 108 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 12
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 2
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
The Dark Kinase Knowledgebase is an an online compendium of knowledge and experimental results of understudied kinases.
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (2)
Protein-Protein Interactions (95)
Nearest Tclin Targets (6)
Upstream (3)
Downstream (3)
1 – 3 of 3
Pathways (17)
Reactome (6)
KEGG (3)
PathwayCommons (3)
WikiPathways (5)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Metabolism | ||||
Reactome | Metabolism of lipids | ||||
Reactome | PI Metabolism | ||||
Reactome | Phospholipid metabolism | ||||
Reactome | Synthesis of PIPs at the Golgi membrane | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Metabolism | ||||
Metabolism of lipids | ||||
PI Metabolism | ||||
Phospholipid metabolism | ||||
Synthesis of PIPs at the Golgi membrane | ||||
Viral Interactions (0)
Gene Ontology Terms (17)
Functions (5)
Components (5)
Processes (7)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Non-traceable Author Statement (NAS) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations ()
GWAS Traits (6)
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
mathematical ability | 3 | 2 | 3 | 68.5 | |||||
alcohol use disorder measurement | 1 | 1 | 1 | 21.5 | |||||
alcohol consumption measurement | 1 | 1 | 1 | 21.5 | |||||
diastolic blood pressure | 1 | 1 | 0 | 1.8 | 15.8 | ||||
glucose measurement | 1 | 1 | 1 | 15.8 | |||||
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
mathematical ability | 3 | 68.5 | |||||
alcohol use disorder measurement | 1 | 21.5 | |||||
alcohol consumption measurement | 1 | 21.5 | |||||
diastolic blood pressure | 0 | 1.8 | 15.8 | ||||
glucose measurement | 1 | 15.8 | |||||
Find similar targets by:
IDG Resources
Orthologs (8)
1 – 5 of 8
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma | VGNC:8607 | 465321 | |||||
Macaque | phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma | 702929 | ||||||
Mouse | MGI:1203730 | 18705 | ||||||
Rat | RGD:620231 | 116720 | ||||||
Dog | phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma | VGNC:44553 | 477681 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma | |||||
Macaque | phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma | |||||
Mouse | ||||||
Rat | ||||||
Dog | phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma | |||||
Publication Statistics
PubMed Score 14.86
PubMed score by year
PubTator Score 7.27
PubTator score by year
Patents
Patents by year
Related Publications
Text Mined References (23)
GeneRif Annotations (5)
Items per page:
0 of 0
PMID | Year | Title |
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