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Tbio
SLC25A12
Calcium-binding mitochondrial carrier protein Aralar1

Protein Summary
Description
Mitochondrial and calcium-binding carrier that catalyzes the calcium-dependent exchange of cytoplasmic glutamate with mitochondrial aspartate across the mitochondrial inner membrane (PubMed:11566871, PubMed:25410934). May have a function in the urea cycle (PubMed:11566871). This gene encodes a calcium-binding mitochondrial carrier protein. The encoded protein localizes to the mitochondria and is involved in the exchange of aspartate for glutamate across the inner mitochondrial membrane. Polymorphisms in this gene may be associated with autism, and mutations in this gene may also be a cause of global cerebral hypomyelination. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Apr 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000422440
  • ENSP00000388658
  • ENSG00000115840

Symbol
  • ARALAR1
  • AGC1
  • ARALAR
  • EIEE39
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
interacting protein
0.98
transcription factor perturbation
0.94
histone modification site profile
0.91
protein domain
0.85


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 90   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 198   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 90   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 198   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
RESOLUTE
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RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (67)
SLC25A13
Tbio
Family:  Transporter
Novelty:  0.00538567
p_int:  0.897425739
p_ni:  0.102574261
Score:  0.697
Data Source:  BioPlex,STRINGDB
TIMM13
Tdark
Family:  Enzyme
Novelty:  0.04802297
Score:  0.989
Data Source:  STRINGDB
TIMM8A
Tbio
Family:  Enzyme
Novelty:  0.00954602
Score:  0.98
Data Source:  STRINGDB
TIMM23
Tbio
Family:  Enzyme
Novelty:  0.06463808
Score:  0.975
Data Source:  STRINGDB
ACO2
Tbio
Family:  Enzyme
Novelty:  0.00276725
Score:  0.972
Data Source:  STRINGDB
CYC1
Tchem
Novelty:  0.01369865
Score:  0.93
Data Source:  STRINGDB
VDAC1
Tbio
Novelty:  0.0011441
Score:  0.928
Data Source:  STRINGDB
ATP5F1A
Tbio
Family:  Enzyme
Novelty:  0.01052213
Score:  0.927
Data Source:  STRINGDB
CS
Tbio
Family:  Enzyme
Novelty:  0.00154214
Score:  0.925
Data Source:  STRINGDB
ATP5F1B
Tbio
Family:  Enzyme
Novelty:  0.01053177
Score:  0.921
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
Aspartate and asparagine metabolism (R-HSA-8963693)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Aspartate and asparagine metabolism
Reactome
Gluconeogenesis
Reactome
Glucose metabolism
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Name
Explore in Pharos
Explore in Source
Aspartate and asparagine metabolism
Gluconeogenesis
Glucose metabolism
Metabolism
Metabolism of amino acids and derivatives
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (19)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Disease Associations (null)
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
3
3
3
84.6
refractive error measurement
2
2
1
8.2
78.2
mathematical ability
2
2
2
70.4
Myopia
2
1
0
4.6
66.3
age at onset
1
1
0
8.2
66.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
3
84.6
refractive error measurement
1
8.2
78.2
mathematical ability
2
70.4
Myopia
0
4.6
66.3
age at onset
0
8.2
66.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 25 member 12
VGNC:9057
459736
Macaque
solute carrier family 25 member 12
695173
Mouse
MGI:1926080
78830
Dog
solute carrier family 25 member 12
VGNC:46292
478798
Horse
solute carrier family 25 member 12
VGNC:23091
100063768
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 25 member 12
Macaque
solute carrier family 25 member 12
Mouse
Dog
solute carrier family 25 member 12
Horse
solute carrier family 25 member 12
Publication Statistics
PubMed Score 90.00
PubMed score by year
PubTator Score 32.71
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title