Tbio CRTAP Cartilage-associated protein

Protein Summary

Description

Necessary for efficient 3-hydroxylation of fibrillar collagen prolyl residues. The protein encoded by this gene is similar to the chicken and mouse CRTAP genes. The encoded protein is a scaffolding protein that may influence the activity of at least one member of the cytohesin/ARNO family in response to specific cellular stimuli. Defects in this gene are associated with osteogenesis imperfecta, a connective tissue disorder characterized by bone fragility and low bone mass. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O75718
• B2RBL6

Gene Name

• CRTAP

Ensembl ID

• ENST00000320954
• ENSP00000323696
• ENSG00000170275

Symbol

• CASP
• OI7
• CASP
• P3H5
• LEPREL3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.98
kinase perturbation	0.97
transcription factor perturbation	0.88
microRNA	0.78
cellular component	0.67

Protein Classes

PANTHER Classes

Protein / Extracellular Matrix Protein / Cartilage-associated Protein

DTO Classes

Protein / Extracellular Structure / Cartilage-associated Protein

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.05   (req: < 5)

Gene RIFs: 15   (req: <= 3)

Antibodies: 241   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.05   (req: >= 5)

Gene RIFs: 15   (req: > 3)

Antibodies: 241   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0