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Tbio
WDHD1
WD repeat and HMG-box DNA-binding protein 1

Protein Summary
Description
Acts as a replication initiation factor that brings together the MCM2-7 helicase and the DNA polymerase alpha/primase complex in order to initiate DNA replication. The protein encoded by this gene contains multiple N-terminal WD40 domains and a C-terminal high mobility group (HMG) box. WD40 domains are found in a variety of eukaryotic proteins and may function as adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly. HMG boxes are found in many eukaryotic proteins involved in chromatin assembly, transcription and replication. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000360586
  • ENSP00000353793
  • ENSG00000198554
  • ENST00000420358
  • ENSP00000399349

Symbol
  • AND1
  • AND1
  • CTF4
  • AND-1
  • CHTF4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.94
protein domain
0.92
histone modification site profile
0.83
transcription factor perturbation
0.8
hub protein
0.79


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 74.06   (req: < 5)
Gene RIFs: 19   (req: <= 3)
Antibodies: 155   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 74.06   (req: >= 5)
Gene RIFs: 19   (req: > 3)
Antibodies: 155   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
1
1
1
25.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
1
25.4
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
WD repeat and HMG-box DNA binding protein 1
VGNC:7041
452918
Macaque
WD repeat and HMG-box DNA binding protein 1
695910
Mouse
MGI:2443514
218973
Rat
RGD:1310200
305827
Dog
WD repeat and HMG-box DNA binding protein 1
VGNC:48347
490701
Species
Name
OMA
EggNOG
Inparanoid
Chimp
WD repeat and HMG-box DNA binding protein 1
Macaque
WD repeat and HMG-box DNA binding protein 1
Mouse
Rat
Dog
WD repeat and HMG-box DNA binding protein 1
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O75717-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (4)
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Mesodermal Commitment Pathway
WikiPathways
Mesodermal Commitment Pathway
WikiPathways
Endoderm Differentiation
WikiPathways
Endoderm Differentiation
Name
Explore in Pharos
Explore in Source
Mesodermal Commitment Pathway
Mesodermal Commitment Pathway
Endoderm Differentiation
Endoderm Differentiation
Protein-Protein Interactions (272)
1 – 10 of 272
NUP50
Tbio
Novelty: 0.03424725
p_int: 0.999999385
p_ni: 6.15e-7
Score: 0.201
Data Source: BioPlex,STRINGDB
CA10
Tbio
Family: Enzyme
Novelty: 0.01053152
p_int: 0.999998758
p_ni: 0.00000122
p_wrong: 2.2e-8
Score: 0.175
Data Source: BioPlex,STRINGDB
IMP3
Tbio
Novelty: 0.42681287
p_int: 0.999946724
p_ni: 0.000053263
p_wrong: 1.3e-8
Data Source: BioPlex
GREM2
Tbio
Novelty: 0.01839564
p_int: 0.99935448
p_ni: 0.000645511
p_wrong: 9e-9
Data Source: BioPlex
ATXN7L1
Tdark
Novelty: 0.43694835
p_int: 0.997500073
p_ni: 0.002499921
p_wrong: 6e-9
Data Source: BioPlex
SPIN2B
Tdark
Novelty: 0.23202718
p_int: 0.995968326
p_ni: 0.004031641
p_wrong: 3.3e-8
Score: 0.187
Data Source: BioPlex,STRINGDB
LMO1
Tbio
Novelty: 0.01670419
p_int: 0.984339331
p_ni: 0.015659233
p_wrong: 0.000001436
Data Source: BioPlex
MGME1
Tbio
Family: Enzyme
Novelty: 0.05284418
p_int: 0.949773984
p_ni: 0.050225378
p_wrong: 6.39e-7
Score: 0.287
Data Source: BioPlex,STRINGDB
CCL26
Tbio
Novelty: 0.00556498
p_int: 0.948204261
p_ni: 0.051784315
p_wrong: 0.000011424
Data Source: BioPlex
C10orf82
Tdark
Novelty: 7.20110868
p_int: 0.92377345
p_ni: 0.072816034
p_wrong: 0.003410516
Data Source: BioPlex
Publication Statistics
PubMed Score  74.06

PubMed score by year
PubTator Score  1285.97

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer