STK16
Serine/threonine-protein kinase 16
Protein Summary
Membrane-associated protein kinase that phosphorylates on serine and threonine residues. In vitro substrates include DRG1, ENO1 and EIF4EBP1. Also autophosphorylates. May be involved in secretory vesicle trafficking or intracellular signaling. May have a role in regulating stromal-epithelial interactions that occur during ductal morphogenesis in the mammary gland. May be involved in TGF-beta signaling. Able to autophosphorylate on Tyr residue; it is however unclear whether it has tyrosine-protein kinase toward other proteins.
- ENST00000396738
- ENSP00000379964
- ENSG00000115661
- ENST00000409638
- ENSP00000386928
- MPSK1
- PKL12
- TSF1
- PSK
- KRCT
- MPSK
- TSF1
- hPSK
- PKL12
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
molecular function | 0.98 | ||
small molecule | 0.89 | ||
transcription factor binding site profile | 0.72 | ||
small molecule perturbation | 0.7 | ||
microRNA | 0.68 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 73.49 (req: < 5)
Gene RIFs: 3 (req: <= 3)
Antibodies: 267 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 73.49 (req: >= 5)
Gene RIFs: 3 (req: > 3)
Antibodies: 267 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 6
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 2
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (2)
Active Ligands (6)
Protein-Protein Interactions (48)
C5orf30
Novelty: 0.2072045
p_int: 0.999998445
p_ni: 0.00000137
p_wrong: 1.85e-7
Score: 0.239
Data Source: BioPlex,STRINGDB
ATG4B
Family: Enzyme
Novelty: 0.0088416
p_int: 0.999993406
p_ni: 0.00000353
p_wrong: 0.000003065
Score: 0.269
Data Source: BioPlex,STRINGDB
UHRF1BP1
Novelty: 0.1588079
p_int: 0.999824893
p_ni: 0.000175107
Score: 0.188
Data Source: BioPlex,STRINGDB
TUBB8
Novelty: 0.06403117
p_int: 0.932631074
p_ni: 0.067368781
p_wrong: 1.46e-7
Data Source: BioPlex
FLG
Novelty: 0.00072986
p_int: 0.839456504
p_ni: 0.160543496
Score: 0.188
Data Source: BioPlex,STRINGDB
NCCRP1
Novelty: 0.04688327
p_int: 0.817149758
p_ni: 0.182850242
Score: 0.173
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (0)
Viral Interactions (0)
Gene Ontology Terms (10)
Functions (4)
Components (4)
Processes (2)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-EC | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations ()
GWAS Traits (16)
Items per page:
1 – 5 of 16
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
reticulocyte count | 6 | 3 | 8 | 95.7 | |||||
reticulocyte measurement | 3 | 2 | 5 | 92.7 | |||||
vitamin C measurement | 1 | 1 | 1 | 79.9 | |||||
mean reticulocyte volume | 1 | 2 | 2 | 77.5 | |||||
red blood cell distribution width | 2 | 1 | 2 | 75.3 | |||||
Items per page:
1 – 5 of 16
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
reticulocyte count | 8 | 95.7 | |||||
reticulocyte measurement | 5 | 92.7 | |||||
vitamin C measurement | 1 | 79.9 | |||||
mean reticulocyte volume | 2 | 77.5 | |||||
red blood cell distribution width | 2 | 75.3 | |||||
Find similar targets by:
IDG Resources
Orthologs (15)
1 – 5 of 15
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | serine/threonine kinase 16 | VGNC:14439 | 743108 | |||||
Macaque | serine/threonine kinase 16 | 702715 | ||||||
Mouse | MGI:1313271 | 20872 | ||||||
Rat | RGD:629474 | 286927 | ||||||
Dog | serine/threonine kinase 16 | VGNC:46906 | 488536 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | serine/threonine kinase 16 | |||||
Macaque | serine/threonine kinase 16 | |||||
Mouse | ||||||
Rat | ||||||
Dog | serine/threonine kinase 16 | |||||
Publication Statistics
PubMed Score 73.49
PubMed score by year
PubTator Score 22.53
PubTator score by year
Patents
Patents by year
Related Publications
Text Mined References (22)
GeneRif Annotations (3)
Items per page:
0 of 0
PMID | Year | Title |
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