Tchem STK16 Serine/threonine-protein kinase 16

Protein Classes

DTO Classes

Protein / Kinase / Protein Kinase / Other Group / Nak Family / Serine/threonine-protein Kinase 16

Protein Summary

Description

Membrane-associated protein kinase that phosphorylates on serine and threonine residues. In vitro substrates include DRG1, ENO1 and EIF4EBP1. Also autophosphorylates. May be involved in secretory vesicle trafficking or intracellular signaling. May have a role in regulating stromal-epithelial interactions that occur during ductal morphogenesis in the mammary gland. May be involved in TGF-beta signaling. Able to autophosphorylate on Tyr residue; it is however unclear whether it has tyrosine-protein kinase toward other proteins.

Uniprot Accession IDs

• O75716
• A8K9H9
• Q5U0F8
• Q96KI2
• Q9BUH4
• Q9UEN3
• Q9UP78

Gene Name

• STK16

Ensembl ID

• ENST00000396738
• ENSP00000379964
• ENSG00000115661
• ENST00000409638
• ENSP00000386928

Symbol

• MPSK1
• PKL12
• TSF1
• PSK
• KRCT
• MPSK
• TSF1
• hPSK
• PKL12

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.98
small molecule	0.89
transcription factor binding site profile	0.72
small molecule perturbation	0.7
microRNA	0.68

Related Tools

ProKinO

The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.

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Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 73.49   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 267   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 73.49   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 267   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 6

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2

Approved Drugs (2)

Explore Approved Drugs

1 – 2 of 2

nintedanib

STK16Tchem Kinase

Kd : 7.74

fedratinib

STK16Tchem Kinase

Kd : 8.18

Active Ligands (6)

Explore Active Ligands

1 – 6 of 6

lestaurtinib

STK16Tchem Kinase

Kd : 7.72

tamatinib

STK16Tchem Kinase

Kd : 8.77

KW-2449

STK16Tchem Kinase

Kd : 7.54

JNJ-28312141

STK16Tchem Kinase

Kd : 7.75

STK16-IN-1

STK16Tchem Kinase

IC50 : 6.53000021

CHEMBL516312

STK16Tchem Kinase

Kd : 7.62

GWAS Traits (16)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 16

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
reticulocyte count	EFO_0007986	6	3	8		95.7
reticulocyte measurement	EFO_0010700	3	2	5		92.7
vitamin C measurement	EFO_0600003	1	1	1		79.9
mean reticulocyte volume	EFO_0010701	1	2	2		77.5
red blood cell distribution width	EFO_0005192	2	1	2		75.3

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 16

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
reticulocyte count	EFO_0007986	8		95.7
reticulocyte measurement	EFO_0010700	5		92.7
vitamin C measurement	EFO_0600003	1		79.9
mean reticulocyte volume	EFO_0010701	2		77.5
red blood cell distribution width	EFO_0005192	2		75.3

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Orthologs (15)

1 – 5 of 15

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	serine/threonine kinase 16	VGNC:14439	743108
Macaque	serine/threonine kinase 16		702715
Mouse	serine/threonine kinase 16	MGI:1313271	20872
Rat	serine/threonine kinase 16	RGD:629474	286927
Dog	serine/threonine kinase 16	VGNC:46906	488536

Species	Name	OMA	EggNOG	Inparanoid
Chimp	serine/threonine kinase 16
Macaque	serine/threonine kinase 16
Mouse	serine/threonine kinase 16
Rat	serine/threonine kinase 16
Dog	serine/threonine kinase 16

Protein Structure (1 Structure, 1 AlphaFold Model)

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Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O75716-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1

PDB Structure Id	Ligand	Method	Resolution (Å)	Residues	Fraction of Total Protein	Pub Year	Title

PDB Structure Id	Fraction of Total Protein	Resolution	Pub Year

Gene Ontology Terms (10)

Functions (4)

Components (4)

Processes (2)

Find Similar Targets

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10

1 – 4 of 4

GO Term	Evidence	Assigned by
ATP binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
non-membrane spanning protein tyrosine kinase activity	Inferred from Electronic Annotation (IEA)	UniProtKB-EC
protein serine/threonine kinase activity	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific	Inferred from Electronic Annotation (IEA)	Ensembl

Protein-Protein Interactions (48)

Explore Interacting Targets

1 – 10 of 48

• See Interactions on String-DB

C5orf30

Tdark

Novelty:  0.2072045

p_int:  0.999998445

p_ni:  0.00000137

p_wrong:  1.85e-7

Score:  0.239

Data Source:  BioPlex,STRINGDB

ATG4B

Tchem

Family:  Enzyme

Novelty:  0.0088416

p_int:  0.999993406

p_ni:  0.00000353

p_wrong:  0.000003065

Score:  0.269

Data Source:  BioPlex,STRINGDB

UHRF1BP1

Tbio

Novelty:  0.1588079

p_int:  0.999824893

p_ni:  0.000175107

Score:  0.188

Data Source:  BioPlex,STRINGDB

TUBB3

Tclin

Novelty:  0.00195963

p_int:  0.93375548

p_ni:  0.06624452

Data Source:  BioPlex

TUBB8

Tclin

Novelty:  0.06403117

p_int:  0.932631074

p_ni:  0.067368781

p_wrong:  1.46e-7

Data Source:  BioPlex

POF1B

Tbio

Novelty:  0.1232792

p_int:  0.92502201

p_ni:  0.07497799

Data Source:  BioPlex

DCAF10

Tdark

Novelty:  2.6713128

p_int:  0.908359092

p_ni:  0.091640908

Data Source:  BioPlex

FLG

Tbio

Novelty:  0.00072986

p_int:  0.839456504

p_ni:  0.160543496

Score:  0.188

Data Source:  BioPlex,STRINGDB

NCCRP1

Tbio

Novelty:  0.04688327

p_int:  0.817149758

p_ni:  0.182850242

Score:  0.173

Data Source:  BioPlex,STRINGDB

FAAH2

Tchem

Family:  Enzyme

Novelty:  0.06197067

Score:  0.754

Data Source:  STRINGDB

Publication Statistics

PubMed Score  73.49

PubMed score by year

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PubTator Score  22.53

PubTator score by year

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Patents

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Amino Acid Sequence

Residue Counts

Protein Sequence

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Ortholog Sequence Conservation

WebLogo Color Code

PolarG S T Y C

NeutralQ N

BasicK R H

AcidicD E

HydrophobicA V L I P W F M

Compare across kinases on ProKinO

Structural Annotations

Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
ATP-binding
Complete proteome
Cytoplasm
Kinase
Lipoprotein
Membrane
Myristate
Nucleotide-binding
Palmitate

GWAS Trait Find Similar Targets

No Header	No Header
BMI-adjusted waist circumference
body height
body mass index
leukocyte count
lymphocyte percentage of leukocytes
mean corpuscular volume
mean reticulocyte volume
monocyte count
neutrophil count
platelet count

MGI Phenotype Find Similar Targets

No Header	No Header
behavior/neurological phenotype
nervous system phenotype