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Tchem
STK16
Serine/threonine-protein kinase 16

Protein Summary
Description
Membrane-associated protein kinase that phosphorylates on serine and threonine residues. In vitro substrates include DRG1, ENO1 and EIF4EBP1. Also autophosphorylates. May be involved in secretory vesicle trafficking or intracellular signaling. May have a role in regulating stromal-epithelial interactions that occur during ductal morphogenesis in the mammary gland. May be involved in TGF-beta signaling. Able to autophosphorylate on Tyr residue; it is however unclear whether it has tyrosine-protein kinase toward other proteins.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000396738
  • ENSP00000379964
  • ENSG00000115661
  • ENST00000409638
  • ENSP00000386928

Symbol
  • MPSK1
  • PKL12
  • TSF1
  • PSK
  • KRCT
  • MPSK
  • TSF1
  • hPSK
  • PKL12
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.98
small molecule
0.89
transcription factor binding site profile
0.72
small molecule perturbation
0.7
microRNA
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 73.41   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 267   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 73.41   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 267   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 6
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
2
1
2
26.3
reticulocyte count
2
1
2
22.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
2
26.3
reticulocyte count
2
22.3
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Gene Ontology Terms (10)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (48)
1 – 10 of 48
C5orf30
Tdark
Novelty: 0.2072045
p_int: 0.999998445
p_ni: 0.00000137
p_wrong: 1.85e-7
Score: 0.239
Data Source: BioPlex,STRINGDB
ATG4B
Tchem
Family: Enzyme
Novelty: 0.0088416
p_int: 0.999993406
p_ni: 0.00000353
p_wrong: 0.000003065
Score: 0.269
Data Source: BioPlex,STRINGDB
UHRF1BP1
Tbio
Novelty: 0.1588079
p_int: 0.999824893
p_ni: 0.000175107
Score: 0.188
Data Source: BioPlex,STRINGDB
TUBB3
Tclin
Novelty: 0.00195963
p_int: 0.93375548
p_ni: 0.06624452
Data Source: BioPlex
TUBB8
Tclin
Novelty: 0.06403117
p_int: 0.932631074
p_ni: 0.067368781
p_wrong: 1.46e-7
Data Source: BioPlex
POF1B
Tbio
Novelty: 0.1232792
p_int: 0.92502201
p_ni: 0.07497799
Data Source: BioPlex
DCAF10
Tdark
Novelty: 2.6713128
p_int: 0.908359092
p_ni: 0.091640908
Data Source: BioPlex
FLG
Tbio
Novelty: 0.00072986
p_int: 0.839456504
p_ni: 0.160543496
Score: 0.188
Data Source: BioPlex,STRINGDB
NCCRP1
Tbio
Novelty: 0.04688327
p_int: 0.817149758
p_ni: 0.182850242
Score: 0.173
Data Source: BioPlex,STRINGDB
FAAH2
Tchem
Family: Enzyme
Novelty: 0.06197067
Score: 0.754
Data Source: STRINGDB
Publication Statistics
PubMed Score  73.41

PubMed score by year
PubTator Score  22.53

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer