Tchem STK16 Serine/threonine-protein kinase 16

Protein Classes

DTO Classes

Protein / Kinase / Protein Kinase / Other Group / Nak Family / Serine/threonine-protein Kinase 16

Protein Summary

Description

Membrane-associated protein kinase that phosphorylates on serine and threonine residues. In vitro substrates include DRG1, ENO1 and EIF4EBP1. Also autophosphorylates. May be involved in secretory vesicle trafficking or intracellular signaling. May have a role in regulating stromal-epithelial interactions that occur during ductal morphogenesis in the mammary gland. May be involved in TGF-beta signaling. Able to autophosphorylate on Tyr residue; it is however unclear whether it has tyrosine-protein kinase toward other proteins.

Uniprot Accession IDs

• O75716
• A8K9H9
• Q5U0F8
• Q96KI2
• Q9BUH4
• Q9UEN3
• Q9UP78

Gene Name

• STK16

Ensembl ID

• ENST00000396738
• ENSP00000379964
• ENSG00000115661
• ENST00000409638
• ENSP00000386928

Symbol

• MPSK1
• PKL12
• TSF1
• PSK
• KRCT
• MPSK
• TSF1
• hPSK
• PKL12

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.98
small molecule	0.89
transcription factor binding site profile	0.72
small molecule perturbation	0.7
microRNA	0.68

IDG Partner Tools

GlyGen

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 73.41   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 267   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 73.41   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 267   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 6

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2

Approved Drugs (2)

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1 – 2 of 2

nintedanib

STK16Tchem Kinase

Kd: 7.74

fedratinib

STK16Tchem Kinase

Kd: 8.18

Active Ligands (6)

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1 – 6 of 6

CHEMBL603469

STK16Tchem Kinase

Kd: 7.72

CHEMBL475251

STK16Tchem Kinase

Kd: 8.77

CHEMBL1908395,CHEMBL1908842

STK16Tchem Kinase

Kd: 7.75

CHEMBL1908397

STK16Tchem Kinase

Kd: 7.54

STK16-IN-1

STK16Tchem Kinase

IC50: 6.53000021

CHEMBL516312

STK16Tchem Kinase

Kd: 7.62

GWAS Traits (2)

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5

1 – 2 of 2

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
reticulocyte measurement	EFO_0010700	2	1	2		26.3
reticulocyte count	EFO_0007986	2	1	2		22.3

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 2 of 2

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
reticulocyte measurement	EFO_0010700	2		26.3
reticulocyte count	EFO_0007986	2		22.3

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Protein Data Bank (1)

1 – 1 of 1

PDB Structure Id	Ligand	Method	Resolution (Å)	M.W. (kDa)	Pub Year	Title

PDB Structure Id	M.W.	Resolution	Pub Year

Gene Ontology Terms (10)

Functions (4)

Components (4)

Processes (2)

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Items per page:

10

1 – 4 of 4

GO Term	Evidence	Assigned by
ATP binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
non-membrane spanning protein tyrosine kinase activity	Inferred from Electronic Annotation (IEA)	UniProtKB-EC
protein serine/threonine kinase activity	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific	Inferred from Electronic Annotation (IEA)	Ensembl

Protein-Protein Interactions (48)

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1 – 10 of 48

• See Interactions on String-DB

C5orf30

Tdark

Novelty: 0.2072045

p_int: 0.999998445

p_ni: 0.00000137

p_wrong: 1.85e-7

Score: 0.239

Data Source: BioPlex,STRINGDB

ATG4B

Tchem

Family: Enzyme

Novelty: 0.0088416

p_int: 0.999993406

p_ni: 0.00000353

p_wrong: 0.000003065

Score: 0.269

Data Source: BioPlex,STRINGDB

UHRF1BP1

Tbio

Novelty: 0.1588079

p_int: 0.999824893

p_ni: 0.000175107

Score: 0.188

Data Source: BioPlex,STRINGDB

TUBB3

Tclin

Novelty: 0.00195963

p_int: 0.93375548

p_ni: 0.06624452

Data Source: BioPlex

TUBB8

Tclin

Novelty: 0.06403117

p_int: 0.932631074

p_ni: 0.067368781

p_wrong: 1.46e-7

Data Source: BioPlex

POF1B

Tbio

Novelty: 0.1232792

p_int: 0.92502201

p_ni: 0.07497799

Data Source: BioPlex

DCAF10

Tdark

Novelty: 2.6713128

p_int: 0.908359092

p_ni: 0.091640908

Data Source: BioPlex

FLG

Tbio

Novelty: 0.00072986

p_int: 0.839456504

p_ni: 0.160543496

Score: 0.188

Data Source: BioPlex,STRINGDB

NCCRP1

Tbio

Novelty: 0.04688327

p_int: 0.817149758

p_ni: 0.182850242

Score: 0.173

Data Source: BioPlex,STRINGDB

FAAH2

Tchem

Family: Enzyme

Novelty: 0.06197067

Score: 0.754

Data Source: STRINGDB

Publication Statistics

PubMed Score  73.41

PubMed score by year

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PubTator Score  22.53

PubTator score by year

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Patents

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Amino Acid Sequence

Residue Counts

Protein Sequence

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Ortholog Sequence Conservation

WebLogo Color Code

PolarG S T Y C

NeutralQ N

BasicK R H

AcidicD E

HydrophobicA V L I P W F M

Compare across kinases on ProKinO

Structural Annotations

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UniProt Keyword Find Similar Targets

3D-structure
ATP-binding
Complete proteome
Cytoplasm
Kinase
Lipoprotein
Membrane
Myristate
Nucleotide-binding
Palmitate

GWAS Trait Find Similar Targets

reticulocyte count
reticulocyte measurement

MGI Phenotype Find Similar Targets

behavior/neurological phenotype
nervous system phenotype