GPX5
Epididymal secretory glutathione peroxidase
Protein Summary
Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione. May constitute a glutathione peroxidase-like protective system against peroxide damage in sperm membrane lipids. This gene belongs to the glutathione peroxidase family. It is specifically expressed in the epididymis in the mammalian male reproductive tract, and is androgen-regulated. Unlike several other characterized glutathione peroxidases, this enzyme is not a selenoprotein, lacking the selenocysteine residue. Thus, it is selenium-independent, and has been proposed to play a role in protecting the membranes of spermatozoa from the damaging effects of lipid peroxidation and/or preventing premature acrosome reaction. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2016]
- ENST00000412168
- ENSP00000392398
- ENSG00000224586
- ENST00000469384
- ENSP00000419935
- ENST00000550775
- ENSP00000450365
- ENSG00000257770
- ENST00000551639
- ENSP00000449271
- EGLP
- GPx-5
- GSHPx-5
- HEL-S-75p
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
tissue | 0.69 | ||
gene perturbation | 0.64 | ||
protein domain | 0.58 | ||
disease | 0.53 | ||
disease perturbation | 0.49 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 83.61 (req: < 5)
Gene RIFs: 3 (req: <= 3)
Antibodies: 88 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 83.61 (req: >= 5)
Gene RIFs: 3 (req: > 3)
Antibodies: 88 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 3
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (86)
Nearest Tclin Targets (5)
Upstream (4)
Downstream (1)
1 – 4 of 4
Pathways (14)
Reactome (3)
KEGG (4)
PathwayCommons (1)
WikiPathways (6)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cellular responses to external stimuli | ||||
Reactome | Cellular responses to stress | ||||
Reactome | Detoxification of Reactive Oxygen Species | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cellular responses to external stimuli | ||||
Cellular responses to stress | ||||
Detoxification of Reactive Oxygen Species | ||||
Viral Interactions (0)
Gene Ontology Terms (4)
Functions (1)
Components (1)
Processes (2)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Traceable Author Statement (TAS) | Reactome | |||
Disease Associations ()
GWAS Traits (44)
Items per page:
1 – 5 of 44
GWAS Trait | EFO ID | ENSG ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|---|
2 | 3 | 0 | 1.1 | 89.1 | ||||||
2 | 3 | 0 | 1.1 | 89.1 | ||||||
adolescent idiopathic scoliosis | 1 | 1 | 0 | 1.2 | 72.5 | |||||
adolescent idiopathic scoliosis | 1 | 1 | 0 | 1.2 | 72.5 | |||||
BMI-adjusted hip circumference | 1 | 3 | 3 | 67.4 | ||||||
Items per page:
1 – 5 of 44
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
0 | 1.1 | 89.1 | |||||
0 | 1.1 | 89.1 | |||||
adolescent idiopathic scoliosis | 0 | 1.2 | 72.5 | ||||
adolescent idiopathic scoliosis | 0 | 1.2 | 72.5 | ||||
BMI-adjusted hip circumference | 3 | 67.4 | |||||
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IDG Resources
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | glutathione peroxidase 5 | VGNC:52012 | 100611241 | |||||
Macaque | glutathione peroxidase 5 | 708014 | ||||||
Mouse | MGI:104886 | 14780 | ||||||
Rat | RGD:69227 | 113919 | ||||||
Dog | glutathione peroxidase 5 | VGNC:41464 | 403877 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | glutathione peroxidase 5 | |||||
Macaque | glutathione peroxidase 5 | |||||
Mouse | ||||||
Rat | ||||||
Dog | glutathione peroxidase 5 | |||||
Publication Statistics
PubMed Score 83.61
PubMed score by year
PubTator Score 12.45
PubTator score by year
Related Publications
Text Mined References (17)
GeneRif Annotations (3)
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0 of 0
PMID | Year | Title |
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