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Tbio
GPX5
Epididymal secretory glutathione peroxidase

Protein Summary
Description
Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione. May constitute a glutathione peroxidase-like protective system against peroxide damage in sperm membrane lipids. This gene belongs to the glutathione peroxidase family. It is specifically expressed in the epididymis in the mammalian male reproductive tract, and is androgen-regulated. Unlike several other characterized glutathione peroxidases, this enzyme is not a selenoprotein, lacking the selenocysteine residue. Thus, it is selenium-independent, and has been proposed to play a role in protecting the membranes of spermatozoa from the damaging effects of lipid peroxidation and/or preventing premature acrosome reaction. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000412168
  • ENSP00000392398
  • ENSG00000224586
  • ENST00000469384
  • ENSP00000419935
  • ENST00000550775
  • ENSP00000450365
  • ENSG00000257770
  • ENST00000551639
  • ENSP00000449271

Symbol
  • EGLP
  • GPx-5
  • GSHPx-5
  • HEL-S-75p
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue
0.69
gene perturbation
0.64
protein domain
0.58
disease
0.53
disease perturbation
0.49


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 83.61   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 88   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 83.61   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 88   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (86)
SOD1
Tchem
Family:  Enzyme
Novelty:  0.00039653
Score:  0.97
Data Source:  STRINGDB
SOD2
Tbio
Family:  Enzyme
Novelty:  0.00084288
Score:  0.967
Data Source:  STRINGDB
SOD3
Tbio
Family:  Enzyme
Novelty:  0.0015758
Score:  0.96
Data Source:  STRINGDB
GSS
Tbio
Family:  Enzyme
Novelty:  0.03002278
Score:  0.951
Data Source:  STRINGDB
ALOX5
Tclin
Family:  Enzyme
Novelty:  0.00062988
Score:  0.909
Data Source:  STRINGDB
GSTM3
Tbio
Family:  Enzyme
Novelty:  0.0078192
Score:  0.888
Data Source:  STRINGDB
CAT
Tbio
Family:  Enzyme
Novelty:  0.00181888
Score:  0.883
Data Source:  STRINGDB
GSR
Tclin
Family:  Enzyme
Novelty:  0.00040107
Score:  0.881
Data Source:  STRINGDB
GSTM2
Tchem
Family:  Enzyme
Novelty:  0.00334543
Score:  0.87
Data Source:  STRINGDB
GSTA4
Tbio
Family:  Enzyme
Novelty:  0.01099229
Score:  0.87
Data Source:  STRINGDB
Nearest Tclin Targets (5)
Explore Nearest Tclin Targets
1 – 4 of 4
PTGS2
Tclin
Family:  Enzyme
KEGG Distance:  2
Common Pathways:  2
PTGS1
Tclin
Family:  Enzyme
KEGG Distance:  2
Common Pathways:  2
ALOX5
Tclin
Family:  Enzyme
KEGG Distance:  2
Common Pathways:  2
Pathways (14)
Cellular responses to external stimuli (R-HSA-8953897)

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Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Reactome
Detoxification of Reactive Oxygen Species
Name
Explore in Pharos
Explore in Source
Cellular responses to external stimuli
Cellular responses to stress
Detoxification of Reactive Oxygen Species
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (44)
Items per page:
1 – 5 of 44
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
3
0
1.1
89.1
2
3
0
1.1
89.1
adolescent idiopathic scoliosis
1
1
0
1.2
72.5
adolescent idiopathic scoliosis
1
1
0
1.2
72.5
BMI-adjusted hip circumference
1
3
3
67.4
Items per page:
1 – 5 of 44
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
89.1
0
1.1
89.1
adolescent idiopathic scoliosis
0
1.2
72.5
adolescent idiopathic scoliosis
0
1.2
72.5
BMI-adjusted hip circumference
3
67.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
glutathione peroxidase 5
VGNC:52012
100611241
Macaque
glutathione peroxidase 5
708014
Mouse
MGI:104886
14780
Rat
RGD:69227
113919
Dog
glutathione peroxidase 5
VGNC:41464
403877
Species
Name
OMA
EggNOG
Inparanoid
Chimp
glutathione peroxidase 5
Macaque
glutathione peroxidase 5
Mouse
Rat
Dog
glutathione peroxidase 5
Publication Statistics
PubMed Score 83.61
PubMed score by year
PubTator Score 12.45
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title