Tbio GPX5 Epididymal secretory glutathione peroxidase

Protein Summary

Description

Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione. May constitute a glutathione peroxidase-like protective system against peroxide damage in sperm membrane lipids. This gene belongs to the glutathione peroxidase family. It is specifically expressed in the epididymis in the mammalian male reproductive tract, and is androgen-regulated. Unlike several other characterized glutathione peroxidases, this enzyme is not a selenoprotein, lacking the selenocysteine residue. Thus, it is selenium-independent, and has been proposed to play a role in protecting the membranes of spermatozoa from the damaging effects of lipid peroxidation and/or preventing premature acrosome reaction. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2016]

Uniprot Accession IDs

• O75715
• A1A4Y0

Gene Name

• GPX5

Ensembl ID

• ENST00000412168
• ENSP00000392398
• ENSG00000224586
• ENST00000469384
• ENSP00000419935
• ENST00000550775
• ENSP00000450365
• ENSG00000257770
• ENST00000551639
• ENSP00000449271

Symbol

• EGLP
• GPx-5
• GSHPx-5
• HEL-S-75p

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
tissue	0.69
gene perturbation	0.64
protein domain	0.58
disease	0.53
disease perturbation	0.49

Protein Classes

PANTHER Classes

Protein / Oxidoreductase / Peroxidase / Epididymal Secretory Glutathione Peroxidase

DTO Classes

Protein / Enzyme / Oxidoreductase / Peroxidase / Epididymal Secretory Glutathione Peroxidase

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 92.33   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 88   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 92.33   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 88   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0