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Tbio
GJB3
Gap junction beta-3 protein

Protein Summary
Description
One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. This gene is a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. Mutations in this gene can cause non-syndromic deafness or erythrokeratodermia variabilis, a skin disorder. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000373362
  • ENSP00000362460
  • ENSG00000188910
  • ENST00000373366
  • ENSP00000362464

Symbol
  • CX31
  • EKV
  • CX31
  • DFNA2
  • EKVP1
  • DFNA2B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.9
PubMedID
0.89
transcription factor perturbation
0.74
protein domain
0.73
tissue sample
0.71


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 131.56   (req: < 5)
Gene RIFs: 37   (req: <= 3)
Antibodies: 292   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 131.56   (req: >= 5)
Gene RIFs: 37   (req: > 3)
Antibodies: 292   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (6)
Gap junction assembly (R-HSA-190861)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gap junction assembly
Reactome
Gap junction trafficking
Reactome
Gap junction trafficking and regulation
Reactome
Membrane Trafficking
Reactome
Vesicle-mediated transport
Name
Explore in Pharos
Explore in Source
Gap junction assembly
Gap junction trafficking
Gap junction trafficking and regulation
Membrane Trafficking
Vesicle-mediated transport
Gene Ontology Terms (13)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Non-traceable Author Statement (NAS)
UniProtKB
Protein-Protein Interactions (64)
1 – 10 of 64
KCNQ4
Tclin
Family: IC
Novelty: 0.00818066
Score: 0.8
Data Source: STRINGDB
RPL34
Tbio
Novelty: 0.00119451
Score: 0.8
Data Source: STRINGDB
SLC26A4
Tbio
Family: Transporter
Novelty: 0.00186048
Score: 0.791
Data Source: STRINGDB
COCH
Tbio
Novelty: 0.00294091
Score: 0.731
Data Source: STRINGDB
GJB2
Tbio
Novelty: 0.00063266
Score: 0.699
Data Source: STRINGDB
GJE1
Tdark
Novelty: 0.29459902
Score: 0.661
Data Source: STRINGDB
PKP1
Tbio
Novelty: 0.01427015
Score: 0.61
Data Source: STRINGDB
GJB4
Tbio
Novelty: 0.0238431
Score: 0.593
Data Source: STRINGDB
GJA1
Tbio
Novelty: 0.00023576
Score: 0.591
Data Source: STRINGDB
GJB5
Tbio
Novelty: 0.06776391
Score: 0.584
Data Source: STRINGDB
Publication Statistics
PubMed Score  131.56

PubMed score by year
PubTator Score  112.44

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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