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Tbio
NUP155
Nuclear pore complex protein Nup155

Protein Summary
Description
Essential component of nuclear pore complex. Could be essessential for embryogenesis. Nucleoporins may be involved both in binding and translocating proteins during nucleocytoplasmic transport. Nucleoporins are proteins that play an important role in the assembly and functioning of the nuclear pore complex (NPC) which regulates the movement of macromolecules across the nuclear envelope (NE). The protein encoded by this gene plays a role in the fusion of NE vesicles and formation of the double membrane NE. The protein may also be involved in cardiac physiology and may be associated with the pathogenesis of atrial fibrillation. Alternative splicing results in multiple transcript variants of this gene. A pseudogene associated with this gene is located on chromosome 6. [provided by RefSeq, May 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000231498
  • ENSP00000231498
  • ENSG00000113569
  • ENST00000381843
  • ENSP00000371265

Symbol
  • KIAA0791
  • N155
  • ATFB15
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
pathway
0.99
transcription factor perturbation
0.91
transcription factor binding site profile
0.88
biological process
0.77


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.28   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 137   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.28   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 137   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (242)
PNOC
Tbio
Novelty:  0.00132014
p_int:  0.99998099
p_ni:  0.00001901
Data Source:  BioPlex
HOXB5
Tbio
Family:  TF
Novelty:  0.01119871
p_int:  0.921895438
p_ni:  0.078104562
Score:  0.244
Data Source:  BioPlex,STRINGDB
ALDH3B1
Tbio
Family:  Enzyme
Novelty:  0.03330389
p_int:  0.904131897
p_ni:  0.095868103
Score:  0.235
Data Source:  BioPlex,STRINGDB
TMEM206
Tdark
Novelty:  0.17311172
p_int:  0.778661763
p_ni:  0.221338237
Data Source:  BioPlex
NUP107
Tbio
Novelty:  0.01994155
Score:  0.999
Data Source:  STRINGDB
NUP205
Tbio
Novelty:  0.06778513
Score:  0.999
Data Source:  Reactome,STRINGDB
NUP133
Tbio
Novelty:  0.02115225
Score:  0.999
Data Source:  STRINGDB
NUP93
Tbio
Novelty:  0.0248311
Score:  0.999
Data Source:  Reactome,STRINGDB
NUP160
Tbio
Novelty:  0.03667026
Score:  0.998
Data Source:  STRINGDB
NUP188
Tbio
Novelty:  0.0698477
Score:  0.998
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (69)
Antiviral mechanism by IFN-stimulated genes (R-HSA-1169410)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 68
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Antiviral mechanism by IFN-stimulated genes
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Cellular response to heat stress
Reactome
Cellular responses to external stimuli
Name
Explore in Pharos
Explore in Source
Antiviral mechanism by IFN-stimulated genes
Cell Cycle
Cell Cycle, Mitotic
Cellular response to heat stress
Cellular responses to external stimuli
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
1
1
1
12.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
1
12.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (17)
1 – 5 of 17
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
nucleoporin 155
VGNC:4110
461913
Macaque
nucleoporin 155
100426110
Mouse
MGI:2181182
170762
Rat
RGD:621199
117021
Dog
nucleoporin 155
VGNC:44046
479360
Species
Name
OMA
EggNOG
Inparanoid
Chimp
nucleoporin 155
Macaque
nucleoporin 155
Mouse
Rat
Dog
nucleoporin 155
Publication Statistics
PubMed Score 24.28
PubMed score by year
PubTator Score 7.61
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title