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Tbio
UTP20
Small subunit processome component 20 homolog

Protein Summary
Description
Involved in 18S pre-rRNA processing. Associates with U3 snoRNA. UTP20 is a component of the U3 small nucleolar RNA (snoRNA) (SNORD3A; MIM 180710) protein complex (U3 snoRNP) and is involved in 18S rRNA processing (Wang et al., 2007 [PubMed 17498821]).[supplied by OMIM, Jun 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261637
  • ENSP00000261637
  • ENSG00000120800

Symbol
  • DRIM
  • DRIM
  • 1A6/DRIM
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.98
virus perturbation
0.9
histone modification site profile
0.89
kinase perturbation
0.81
hub protein
0.75


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.76   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 41   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.76   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 41   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.4
33.6
age at onset
1
1
0
1.4
33.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.4
33.6
age at onset
0
1.4
33.6
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
UTP20, small subunit processome component
VGNC:8589
452169
Macaque
UTP20, small subunit processome component
696472
Mouse
MGI:1917933
70683
Rat
RGD:1560606
314713
Dog
UTP20, small subunit processome component
VGNC:48211
475441
Species
Name
OMA
EggNOG
Inparanoid
Chimp
UTP20, small subunit processome component
Macaque
UTP20, small subunit processome component
Mouse
Rat
Dog
UTP20, small subunit processome component
Protein Structure (0 Structures, 8 AlphaFold Models)
RepresentationColor Scheme

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (5)
Major pathway of rRNA processing in the nucleolus and cytosol (R-HSA-6791226)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Major pathway of rRNA processing in the nucleolus and cytosol
Reactome
Metabolism of RNA
Reactome
rRNA modification in the nucleus and cytosol
Reactome
rRNA processing
Reactome
rRNA processing in the nucleus and cytosol
Name
Explore in Pharos
Explore in Source
Major pathway of rRNA processing in the nucleolus and cytosol
Metabolism of RNA
rRNA modification in the nucleus and cytosol
rRNA processing
rRNA processing in the nucleus and cytosol
Gene Ontology Terms (13)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Protein-Protein Interactions (219)
1 – 10 of 219
GYPB
Tbio
Novelty: 0.00442195
p_int: 0.999985255
p_ni: 0.000014745
Data Source: BioPlex
OPALIN
Tdark
Novelty: 0.08221612
p_int: 0.999972505
p_ni: 0.000027494
p_wrong: 1e-9
Data Source: BioPlex
SCN3B
Tbio
Family: IC
Novelty: 0.0438123
p_int: 0.999913449
p_ni: 0.000086551
Data Source: BioPlex
BSG
Tbio
Novelty: 0.0010285
p_int: 0.999823662
p_ni: 0.000176338
Data Source: BioPlex
CD70
Tbio
Novelty: 0.00420393
p_int: 0.999723741
p_ni: 0.000276259
Data Source: BioPlex
TNFRSF1A
Tchem
Novelty: 0.00037847
p_int: 0.999685128
p_ni: 0.000314872
Data Source: BioPlex
PBXIP1
Tbio
Novelty: 0.15404864
p_int: 0.999672066
p_ni: 0.000327934
Data Source: BioPlex
JTB
Tbio
Novelty: 0.06646216
p_int: 0.998927541
p_ni: 0.001072458
Data Source: BioPlex
CD274
Tclin
Novelty: 0.00013449
p_int: 0.997525367
p_ni: 0.002474633
Data Source: BioPlex
CLMP
Tbio
Novelty: 0.01435374
p_int: 0.995119163
p_ni: 0.004880837
Score: 0.239
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  12.76

PubMed score by year
PubTator Score  9.06

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer