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Tbio
ADAP1
Arf-GAP with dual PH domain-containing protein 1

Protein Summary
Description
GTPase-activating protein for the ADP ribosylation factor family (Probable). Binds phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and inositol 1,3,4,5-tetrakisphosphate (InsP4).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265846
  • ENSP00000265846
  • ENSG00000105963
  • ENST00000449296
  • ENSP00000407267
  • ENST00000539900
  • ENSP00000442682
  • ENST00000611167
  • ENSP00000481154

Symbol
  • CENTA1
  • GCS1L
  • CENTA1
  • p42IP4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.79
transcription factor binding site profile
0.66
tissue
0.57
interacting protein
0.52
tissue sample
0.51


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.58   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 210   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.58   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 210   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (4)
1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (6)
Nuclear signaling by ERBB4 (R-HSA-1251985)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Nuclear signaling by ERBB4
Reactome
Signal Transduction
Reactome
Signaling by ERBB4
Reactome
Signaling by Receptor Tyrosine Kinases
Name
Explore in Pharos
Explore in Source
Nuclear signaling by ERBB4
Signal Transduction
Signaling by ERBB4
Signaling by Receptor Tyrosine Kinases
Gene Ontology Terms (11)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (56)
1 – 10 of 56
KIF13B
Tbio
Novelty: 0.04039443
Score: 0.985
Data Source: STRINGDB
ARF6
Tbio
Family: Enzyme
Novelty: 0.00305495
Score: 0.976
Data Source: STRINGDB
MYADML2
Tdark
Score: 0.747
Data Source: STRINGDB
CNP
Tbio
Family: Enzyme
Novelty: 0.00738449
Score: 0.723
Data Source: STRINGDB
LMF1
Tbio
Family: Enzyme
Novelty: 0.04721405
Score: 0.703
Data Source: STRINGDB
COPS3
Tbio
Novelty: 0.07789318
Score: 0.692
Data Source: STRINGDB
NCL
Tbio
Novelty: 0.00135718
Score: 0.675
Data Source: STRINGDB
LRRC18
Tdark
Novelty: 1.47887324
Score: 0.647
Data Source: STRINGDB
VSTM4
Tdark
Novelty: 0.95454545
Score: 0.625
Data Source: STRINGDB
RASD1
Tbio
Family: Enzyme
Novelty: 0.00720111
Score: 0.62
Data Source: STRINGDB
Publication Statistics
PubMed Score  25.58

PubMed score by year
PubTator Score  17.65

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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