Protein Summary
Enzyme with a broad specificity. Dephosphorylates CDK2 and CDK6 in vitro. Dephosphorylates PRKAA1 and PRKAA2. Inhibits TBK1-mediated antiviral signaling by dephosphorylating it at 'Ser-172'. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB. The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase has been shown to dephosphorylate cyclin-dependent kinases (CDKs), and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to cause cell-growth arrest or cell death. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional transcript variants have been described, but currently do not represent full-length sequences. [provided by RefSeq, Jul 2008]
- ENST00000282412
- ENSP00000282412
- ENSG00000138032
- ENST00000345249
- ENSP00000326089
- ENST00000378551
- ENSP00000367813
- ENST00000409432
- ENSP00000387287
- PP2CB
- PP2CB
- PP2CBETA
- PP2C-beta
- PPC2BETAX
- PP2C-beta-X
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
transcription factor perturbation | 0.98 | ||
virus perturbation | 0.98 | ||
kinase perturbation | 0.95 | ||
interacting protein | 0.93 | ||
disease perturbation | 0.87 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 44.03 (req: < 5)
Gene RIFs: 15 (req: <= 3)
Antibodies: 315 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 44.03 (req: >= 5)
Gene RIFs: 15 (req: > 3)
Antibodies: 315 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 10
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 5
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (5)
Protein-Protein Interactions (135)
HEATR5A
Novelty: 4.84461801
p_int: 0.999999977
p_ni: 2.3e-8
p_wrong: 1e-9
Score: 0.199
Data Source: BioPlex,STRINGDB
PPM1A
Family: Enzyme
Novelty: 0.01464968
p_int: 0.999999759
p_ni: 2.41e-7
Score: 0.719
Data Source: BioPlex,STRINGDB
FEZ2
Novelty: 0.1716508
p_int: 0.999986837
p_ni: 0.000013155
p_wrong: 7e-9
Score: 0.188
Data Source: BioPlex,STRINGDB
BPGM
Family: Enzyme
Novelty: 0.03437401
p_int: 0.999875829
p_ni: 0.000124171
Score: 0.183
Data Source: BioPlex,STRINGDB
CERKL
Family: Enzyme
Novelty: 0.04190552
p_int: 0.997141055
p_ni: 0.002858945
Score: 0.582
Data Source: BioPlex,STRINGDB
PAXX
Novelty: 0.03754932
p_int: 0.997104803
p_ni: 0.002893647
p_wrong: 0.00000155
Score: 0.204
Data Source: BioPlex,STRINGDB
MINDY2
Novelty: 0.46783751
p_int: 0.975941726
p_ni: 0.024058274
Score: 0.192
Data Source: BioPlex,STRINGDB
COX4I1
Family: Enzyme
Novelty: 0.00208873
p_int: 0.962754848
p_ni: 0.037245152
Data Source: BioPlex
Nearest Tclin Targets
Pathways (8)
Reactome (5)
KEGG (1)
WikiPathways (2)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Antiviral mechanism by IFN-stimulated genes | ||||
Reactome | Cytokine Signaling in Immune system | ||||
Reactome | ISG15 antiviral mechanism | ||||
Reactome | Immune System | ||||
Reactome | Interferon Signaling | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Antiviral mechanism by IFN-stimulated genes | ||||
Cytokine Signaling in Immune system | ||||
ISG15 antiviral mechanism | ||||
Immune System | ||||
Interferon Signaling | ||||
Viral Interactions (0)
Gene Ontology Terms (13)
Functions (3)
Components (3)
Processes (7)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations ()
GWAS Traits (13)
Items per page:
1 – 5 of 13
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
body height | 1 | 1 | 1 | 68.6 | |||||
chronotype measurement | 2 | 2 | 2 | 65.4 | |||||
alcohol consumption measurement | 4 | 3 | 4 | 49.1 | |||||
daytime rest measurement | 1 | 1 | 1 | 46.9 | |||||
self reported educational attainment | 1 | 1 | 1 | 21.5 | |||||
Items per page:
1 – 5 of 13
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
body height | 1 | 68.6 | |||||
chronotype measurement | 2 | 65.4 | |||||
alcohol consumption measurement | 4 | 49.1 | |||||
daytime rest measurement | 1 | 46.9 | |||||
self reported educational attainment | 1 | 21.5 | |||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | protein phosphatase, Mg2+/Mn2+ dependent 1B | VGNC:8255 | 470365 | |||||
Macaque | protein phosphatase, Mg2+/Mn2+ dependent 1B | 713918 | ||||||
Mouse | MGI:101841 | 19043 | ||||||
Rat | RGD:3374 | 24667 | ||||||
Dog | protein phosphatase, Mg2+/Mn2+ dependent 1B | VGNC:44863 | 474573 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | protein phosphatase, Mg2+/Mn2+ dependent 1B | |||||
Macaque | protein phosphatase, Mg2+/Mn2+ dependent 1B | |||||
Mouse | ||||||
Rat | ||||||
Dog | protein phosphatase, Mg2+/Mn2+ dependent 1B | |||||
Publication Statistics
PubMed Score 44.03
PubMed score by year
PubTator Score 23.41
PubTator score by year
Related Publications
Text Mined References (36)
GeneRif Annotations (15)
Items per page:
0 of 0
PMID | Year | Title |
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