Tchem PPM1B Protein phosphatase 1B

Protein Classes

PANTHER Classes

Protein / Hydrolase / Phosphatase / Protein Phosphatase / Protein Phosphatase 1B

Protein / Enzyme Modulator / Kinase Modulator / Kinase Inhibitor / Protein Phosphatase 1B

DTO Classes

Protein / Enzyme / Hydrolase / Phosphatase / Protein Phosphatase / Protein Phosphatase 1B

Protein Summary

Description

Enzyme with a broad specificity. Dephosphorylates CDK2 and CDK6 in vitro. Dephosphorylates PRKAA1 and PRKAA2. Inhibits TBK1-mediated antiviral signaling by dephosphorylating it at 'Ser-172'. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB. The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase has been shown to dephosphorylate cyclin-dependent kinases (CDKs), and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to cause cell-growth arrest or cell death. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional transcript variants have been described, but currently do not represent full-length sequences. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O75688
• Q461Q2
• Q4J6C1
• Q4J6C2
• Q658R4
• Q96ER6
• Q9HAY8

Gene Name

• PPM1B

Ensembl ID

• ENST00000282412
• ENSP00000282412
• ENSG00000138032
• ENST00000345249
• ENSP00000326089
• ENST00000378551
• ENSP00000367813
• ENST00000409432
• ENSP00000387287

Symbol

• PP2CB
• PP2CB
• PP2CBETA
• PP2C-beta
• PPC2BETAX
• PP2C-beta-X

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.98
virus perturbation	0.98
kinase perturbation	0.95
interacting protein	0.93
disease perturbation	0.87

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Target Illumination GWAS Analytics (TIGA)

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GENEVA

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.89   (req: < 5)

Gene RIFs: 15   (req: <= 3)

Antibodies: 315   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.89   (req: >= 5)

Gene RIFs: 15   (req: > 3)

Antibodies: 315   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 5

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Active Ligands (5)

Explore Active Ligands

1 – 5 of 5

CHEMBL280487

PPM1BTchem Enzyme

IC50 : 6.9

CHEMBL318253

PPM1BTchem Enzyme

IC50 : 6

CHEMBL1237212

PPM1BTchem Enzyme

IC50 : 6.24

CHEMBL48449

PPM1BTchem Enzyme

IC50 : 6.37

CHEMBL421377

PPM1BTchem Enzyme

IC50 : 9.52

GWAS Traits (2)

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GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
self reported educational attainment	EFO_0004784	1	1	1		52
body height	EFO_0004339	1	1	1		47.8

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
self reported educational attainment	EFO_0004784	1		52
body height	EFO_0004339	1		47.8

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Orthologs (12)

1 – 5 of 12

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	protein phosphatase, Mg2+/Mn2+ dependent 1B	VGNC:8255	470365
Macaque	protein phosphatase, Mg2+/Mn2+ dependent 1B		713918
Mouse	protein phosphatase 1B, magnesium dependent, beta isoform	MGI:101841	19043
Rat	protein phosphatase, Mg2+/Mn2+ dependent, 1B	RGD:3374	24667
Dog	protein phosphatase, Mg2+/Mn2+ dependent 1B	VGNC:44863	474573

Species	Name	OMA	EggNOG	Inparanoid
Chimp	protein phosphatase, Mg2+/Mn2+ dependent 1B
Macaque	protein phosphatase, Mg2+/Mn2+ dependent 1B
Mouse	protein phosphatase 1B, magnesium dependent, beta isoform
Rat	protein phosphatase, Mg2+/Mn2+ dependent, 1B
Dog	protein phosphatase, Mg2+/Mn2+ dependent 1B

Protein Data Bank (1)

1 – 1 of 1

PDB Structure Id	Ligand	Method	Resolution (Å)	M.W. (kDa)	Pub Year	Title

PDB Structure Id	M.W.	Resolution	Pub Year

Pathways (8)

Reactome (5)

KEGG (1)

WikiPathways (2)

Antiviral mechanism by IFN-stimulated genes (R-HSA-1169410)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Antiviral mechanism by IFN-stimulated genes	82 targets	R-HSA-1169410
Reactome	Cytokine Signaling in Immune system	922 targets	R-HSA-1280215
Reactome	ISG15 antiviral mechanism	74 targets	R-HSA-1169408
Reactome	Immune System	2246 targets	R-HSA-168256
Reactome	Interferon Signaling	280 targets	R-HSA-913531

Name	Explore in Pharos	Explore in Source
Antiviral mechanism by IFN-stimulated genes	82 targets	R-HSA-1169410
Cytokine Signaling in Immune system	922 targets	R-HSA-1280215
ISG15 antiviral mechanism	74 targets	R-HSA-1169408
Immune System	2246 targets	R-HSA-168256
Interferon Signaling	280 targets	R-HSA-913531

Gene Ontology Terms (13)

Functions (3)

Components (3)

Processes (7)

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1 – 3 of 3

GO Term	Evidence	Assigned by
protein serine/threonine phosphatase activity	Inferred from Direct Assay (IDA)	UniProtKB
magnesium ion binding	Inferred from Electronic Annotation (IEA)	InterPro
manganese ion binding	Inferred from Electronic Annotation (IEA)	InterPro

Protein-Protein Interactions (135)

Explore Interacting Targets

1 – 10 of 135

• See Interactions on String-DB

HEATR5A

Tdark

Novelty: 4.84461801

p_int: 0.999999977

p_ni: 2.3e-8

p_wrong: 1e-9

Score: 0.199

Data Source: BioPlex,STRINGDB

PPM1A

Tchem

Family: Enzyme

Novelty: 0.01464968

p_int: 0.999999759

p_ni: 2.41e-7

Score: 0.719

Data Source: BioPlex,STRINGDB

FEZ2

Tbio

Novelty: 0.1716508

p_int: 0.999986837

p_ni: 0.000013155

p_wrong: 7e-9

Score: 0.188

Data Source: BioPlex,STRINGDB

BPGM

Tbio

Family: Enzyme

Novelty: 0.03437401

p_int: 0.999875829

p_ni: 0.000124171

Score: 0.183

Data Source: BioPlex,STRINGDB

THUMPD3

Tdark

Novelty: 0.23224828

p_int: 0.998116084

p_ni: 0.001883916

Data Source: BioPlex

CERKL

Tbio

Family: Enzyme

Novelty: 0.04190552

p_int: 0.997141055

p_ni: 0.002858945

Score: 0.582

Data Source: BioPlex,STRINGDB

PAXX

Tbio

Novelty: 0.03754932

p_int: 0.997104803

p_ni: 0.002893647

p_wrong: 0.00000155

Score: 0.204

Data Source: BioPlex,STRINGDB

MINDY2

Tbio

Novelty: 0.46783751

p_int: 0.975941726

p_ni: 0.024058274

Score: 0.192

Data Source: BioPlex,STRINGDB

PVR

Tbio

Novelty: 0.00215811

p_int: 0.963327662

p_ni: 0.036672338

Data Source: BioPlex

COX4I1

Tbio

Family: Enzyme

Novelty: 0.00208873

p_int: 0.962754848

p_ni: 0.037245152

Data Source: BioPlex

Publication Statistics

PubMed Score  41.89

PubMed score by year

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PubTator Score  23.41

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

3D-structure
Alternative splicing
Complete proteome
Cytoplasm
Hydrolase
Isopeptide bond
Lipoprotein
Magnesium
Manganese
Membrane

GWAS Trait Find Similar Targets

body height
self reported educational attainment

MGI Phenotype Find Similar Targets

cellular phenotype
embryo phenotype
mortality/aging