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Tchem
PPM1B
Protein phosphatase 1B

Protein Summary
Description
Enzyme with a broad specificity. Dephosphorylates CDK2 and CDK6 in vitro. Dephosphorylates PRKAA1 and PRKAA2. Inhibits TBK1-mediated antiviral signaling by dephosphorylating it at 'Ser-172'. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB. The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase has been shown to dephosphorylate cyclin-dependent kinases (CDKs), and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to cause cell-growth arrest or cell death. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional transcript variants have been described, but currently do not represent full-length sequences. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000282412
  • ENSP00000282412
  • ENSG00000138032
  • ENST00000345249
  • ENSP00000326089
  • ENST00000378551
  • ENSP00000367813
  • ENST00000409432
  • ENSP00000387287

Symbol
  • PP2CB
  • PP2CB
  • PP2CBETA
  • PP2C-beta
  • PPC2BETAX
  • PP2C-beta-X
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.98
virus perturbation
0.98
kinase perturbation
0.95
interacting protein
0.93
disease perturbation
0.87


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.89   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 315   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.89   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 315   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 5
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
1
1
52
body height
1
1
1
47.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
52
body height
1
47.8
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protein phosphatase, Mg2+/Mn2+ dependent 1B
VGNC:8255
470365
Macaque
protein phosphatase, Mg2+/Mn2+ dependent 1B
713918
Mouse
MGI:101841
19043
Rat
RGD:3374
24667
Dog
protein phosphatase, Mg2+/Mn2+ dependent 1B
VGNC:44863
474573
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protein phosphatase, Mg2+/Mn2+ dependent 1B
Macaque
protein phosphatase, Mg2+/Mn2+ dependent 1B
Mouse
Rat
Dog
protein phosphatase, Mg2+/Mn2+ dependent 1B
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (8)
Antiviral mechanism by IFN-stimulated genes (R-HSA-1169410)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Antiviral mechanism by IFN-stimulated genes
Reactome
Cytokine Signaling in Immune system
Reactome
ISG15 antiviral mechanism
Reactome
Immune System
Reactome
Interferon Signaling
Name
Explore in Pharos
Explore in Source
Antiviral mechanism by IFN-stimulated genes
Cytokine Signaling in Immune system
ISG15 antiviral mechanism
Immune System
Interferon Signaling
Protein-Protein Interactions (135)
1 – 10 of 135
HEATR5A
Tdark
Novelty: 4.84461801
p_int: 0.999999977
p_ni: 2.3e-8
p_wrong: 1e-9
Score: 0.199
Data Source: BioPlex,STRINGDB
PPM1A
Tchem
Family: Enzyme
Novelty: 0.01464968
p_int: 0.999999759
p_ni: 2.41e-7
Score: 0.719
Data Source: BioPlex,STRINGDB
FEZ2
Tbio
Novelty: 0.1716508
p_int: 0.999986837
p_ni: 0.000013155
p_wrong: 7e-9
Score: 0.188
Data Source: BioPlex,STRINGDB
BPGM
Tbio
Family: Enzyme
Novelty: 0.03437401
p_int: 0.999875829
p_ni: 0.000124171
Score: 0.183
Data Source: BioPlex,STRINGDB
THUMPD3
Tdark
Novelty: 0.23224828
p_int: 0.998116084
p_ni: 0.001883916
Data Source: BioPlex
CERKL
Tbio
Family: Enzyme
Novelty: 0.04190552
p_int: 0.997141055
p_ni: 0.002858945
Score: 0.582
Data Source: BioPlex,STRINGDB
PAXX
Tbio
Novelty: 0.03754932
p_int: 0.997104803
p_ni: 0.002893647
p_wrong: 0.00000155
Score: 0.204
Data Source: BioPlex,STRINGDB
MINDY2
Tbio
Novelty: 0.46783751
p_int: 0.975941726
p_ni: 0.024058274
Score: 0.192
Data Source: BioPlex,STRINGDB
PVR
Tbio
Novelty: 0.00215811
p_int: 0.963327662
p_ni: 0.036672338
Data Source: BioPlex
COX4I1
Tbio
Family: Enzyme
Novelty: 0.00208873
p_int: 0.962754848
p_ni: 0.037245152
Data Source: BioPlex
Publication Statistics
PubMed Score  41.89

PubMed score by year
PubTator Score  23.41

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer