You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
SURF6
Surfeit locus protein 6

Protein Summary
Description
Binds to both DNA and RNA in vitro, with a stronger binding capacity for RNA. May represent a nucleolar constitutive protein involved in ribosomal biosynthesis or assembly (By similarity). This gene encodes a conserved protein that is localized to the nucleolus. The encoded protein may function as a nucleolar-matrix protein with nucleic acid-binding properties. There is a pseudogene for this gene on chromosome Y. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000372022
  • ENSP00000361092
  • ENSG00000148296
  • ENST00000629980
  • ENSP00000485909
  • ENSG00000281309

Symbol
  • SURF-6
  • RRP14
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.78
cell type or tissue
0.72
tissue sample
0.66
transcription factor
0.66
cellular component
0.63


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.62   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 115   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.62   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 115   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:98447
20935
Dog
surfeit 6
100856018
Horse
surfeit 6
VGNC:23770
100066565
Cow
surfeit 6
VGNC:35485
511610
Xenopus
surfeit 6
XB-GENE-969953
493251
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Dog
surfeit 6
Horse
surfeit 6
Cow
surfeit 6
Xenopus
surfeit 6
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O75683-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (8)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Protein-Protein Interactions (234)
1 – 10 of 234
H1FOO
Tbio
Novelty: 0.02189067
p_int: 0.954481147
p_ni: 0.045518853
Data Source: BioPlex
RPL11
Tbio
Novelty: 0.00448962
p_int: 0.951324195
p_ni: 0.048675805
Score: 0.608
Data Source: BioPlex,STRINGDB
HIST1H1A
Tbio
Novelty: 0.00123818
p_int: 0.912942671
p_ni: 0.087057329
Score: 0.514
Data Source: BioPlex,STRINGDB
E4F1
Tbio
Family: TF
Novelty: 0.02192338
p_int: 0.905953629
p_ni: 0.094046371
Data Source: BioPlex
DGCR8
Tbio
Novelty: 0.00271221
p_int: 0.863937427
p_ni: 0.136062573
Data Source: BioPlex
RPL6
Tbio
Novelty: 0.01742007
p_int: 0.856815996
p_ni: 0.143184003
Score: 0.799
Data Source: BioPlex,STRINGDB
CNBP
Tbio
Novelty: 0.00404247
p_int: 0.856216492
p_ni: 0.143783508
Score: 0.438
Data Source: BioPlex,STRINGDB
PUM3
Tbio
Novelty: 0.02344206
p_int: 0.849942329
p_ni: 0.150057666
p_wrong: 5e-9
Score: 0.923
Data Source: BioPlex,STRINGDB
MAP7
Tbio
Novelty: 0.01976296
p_int: 0.84891171
p_ni: 0.15108829
Data Source: BioPlex
PRDM5
Tbio
Family: TF; Epigenetic
Novelty: 0.01689997
p_int: 0.817913658
p_ni: 0.182086342
Data Source: BioPlex
Publication Statistics
PubMed Score  22.62

PubMed score by year
PubTator Score  9.56

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer