Tbio SURF6 Surfeit locus protein 6

Protein Summary

Description

Binds to both DNA and RNA in vitro, with a stronger binding capacity for RNA. May represent a nucleolar constitutive protein involved in ribosomal biosynthesis or assembly (By similarity). This gene encodes a conserved protein that is localized to the nucleolus. The encoded protein may function as a nucleolar-matrix protein with nucleic acid-binding properties. There is a pseudogene for this gene on chromosome Y. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Uniprot Accession IDs

• O75683
• Q5T8U1
• Q9BRK9
• Q9BTZ5
• Q9UK24

Gene Name

• SURF6

Ensembl ID

• ENST00000372022
• ENSP00000361092
• ENSG00000148296
• ENST00000629980
• ENSP00000485909
• ENSG00000281309

Symbol

• SURF-6
• RRP14

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor binding site profile	0.78
cell type or tissue	0.72
tissue sample	0.66
transcription factor	0.66
cellular component	0.63

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Surfeit Locus Protein 6

DTO Classes

Protein / Nucleic Acid Binding / Surfeit Locus Protein 6

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.17   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 115   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.17   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 115   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0