You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
RPS6KA4
Ribosomal protein S6 kinase alpha-4

Protein Summary
Description
Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factor RELA, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes. Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin. Plays an essential role in the control of RELA transcriptional activity in response to TNF. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate 'Ser-28' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14). In lipopolysaccharide-stimulated primary macrophages, acts downstre ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000334205
  • ENSP00000333896
  • ENSG00000162302

Symbol
  • MSK2
  • MSK2
  • RSK-B
  • S6K-alpha-4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
drug perturbation
0.99
molecular function
0.99
protein domain
0.97
disease perturbation
0.93


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.82   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 240   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.82   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 240   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 6
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (65)
MAPK14
Tchem
Family:  Kinase
Novelty:  0.00045138
p_int:  0.999999903
p_ni:  9.7e-8
Score:  0.965
Data Source:  BioPlex,STRINGDB
HSP90AB3P
Tdark
p_int:  0.999999751
p_ni:  2.49e-7
Data Source:  BioPlex
MYLK2
Tchem
Family:  Kinase
Novelty:  0.0080273
p_int:  0.999999632
p_ni:  3.68e-7
Score:  0.537
Data Source:  BioPlex,STRINGDB
HSP90AA4P
Tdark
p_int:  0.999999338
p_ni:  6.62e-7
Data Source:  BioPlex
HSP90AB4P
Tdark
p_int:  0.99999927
p_ni:  7.3e-7
Data Source:  BioPlex
CSNK2B
Tbio
Family:  Kinase
Novelty:  0.00152367
p_int:  0.999991027
p_ni:  0.000008972
p_wrong:  1e-9
Score:  0.177
Data Source:  BioPlex,STRINGDB
HSP90AA5P
Tdark
p_int:  0.999987399
p_ni:  0.000012601
Data Source:  BioPlex
KLHDC3
Tbio
Novelty:  0.63840156
p_int:  0.999901648
p_ni:  0.000098342
p_wrong:  1e-8
Score:  0.191
Data Source:  BioPlex,STRINGDB
MAPK4
Tbio
Family:  Kinase
Novelty:  0.0223868
p_int:  0.999878617
p_ni:  0.000121189
p_wrong:  1.93e-7
Score:  0.352
Data Source:  BioPlex,STRINGDB
FKBP5
Tchem
Family:  Enzyme
Novelty:  0.00214511
p_int:  0.999676564
p_ni:  0.000323436
Data Source:  BioPlex
Pathways (16)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Developmental Biology
Reactome
L1CAM interactions
Reactome
Recycling pathway of L1
Name
Explore in Pharos
Explore in Source
Axon guidance
Developmental Biology
L1CAM interactions
Recycling pathway of L1
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (52)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
6
5
12
94.2
2
2
0
1.2
90
high density lipoprotein cholesterol measurement
8
1
8
88.7
urate measurement
1
4
4
86.1
1
1
0
1.2
77.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
12
94.2
0
1.2
90
high density lipoprotein cholesterol measurement
8
88.7
urate measurement
4
86.1
0
1.2
77.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ribosomal protein S6 kinase A4
VGNC:8305
451715
Macaque
ribosomal protein S6 kinase A4
717574
Mouse
MGI:1930076
56613
Rat
RGD:1307277
361715
Dog
ribosomal protein S6 kinase A4
VGNC:45741
612105
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ribosomal protein S6 kinase A4
Macaque
ribosomal protein S6 kinase A4
Mouse
Rat
Dog
ribosomal protein S6 kinase A4
Publication Statistics
PubMed Score 22.82
PubMed score by year
PubTator Score 20.94
PubTator score by year
Patents
Patents by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title