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Tchem
RPS6KA4
Ribosomal protein S6 kinase alpha-4

Protein Summary
Description
Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factor RELA, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes. Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin. Plays an essential role in the control of RELA transcriptional activity in response to TNF. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate 'Ser-28' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14). In lipopolysaccharide-stimulated primary macrophages, acts downstre ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000334205
  • ENSP00000333896
  • ENSG00000162302

Symbol
  • MSK2
  • MSK2
  • RSK-B
  • S6K-alpha-4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
drug perturbation
0.99
molecular function
0.99
protein domain
0.97
disease perturbation
0.93


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.9   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 240   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.9   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 240   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 4
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (16)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Developmental Biology
Reactome
L1CAM interactions
Reactome
Recycling pathway of L1
Name
Explore in Pharos
Explore in Source
Axon guidance
Developmental Biology
L1CAM interactions
Recycling pathway of L1
Protein-Protein Interactions (65)
1 – 10 of 65
MAPK14
Tchem
Family: Kinase
Novelty: 0.00018655
p_int: 0.999999903
p_ni: 9.7e-8
Score: 0.965
Data Source: BioPlex,STRINGDB
HSP90AB3P
Tdark
p_int: 0.999999751
p_ni: 2.49e-7
Data Source: BioPlex
MYLK2
Tchem
Family: Kinase
Novelty: 0.00918962
p_int: 0.999999632
p_ni: 3.68e-7
Score: 0.537
Data Source: BioPlex,STRINGDB
HSP90AA4P
Tdark
p_int: 0.999999338
p_ni: 6.62e-7
Data Source: BioPlex
HSP90AB4P
Tdark
p_int: 0.99999927
p_ni: 7.3e-7
Data Source: BioPlex
CSNK2B
Tbio
Family: Kinase
Novelty: 0.00171173
p_int: 0.999991027
p_ni: 0.000008972
p_wrong: 1e-9
Score: 0.177
Data Source: BioPlex,STRINGDB
HSP90AA5P
Tdark
p_int: 0.999987399
p_ni: 0.000012601
Data Source: BioPlex
KLHDC3
Tdark
Novelty: 0.27149321
p_int: 0.999901648
p_ni: 0.000098342
p_wrong: 1e-8
Score: 0.191
Data Source: BioPlex,STRINGDB
MAPK4
Tbio
Family: Kinase
Novelty: 0.04156197
p_int: 0.999878617
p_ni: 0.000121189
p_wrong: 1.93e-7
Score: 0.352
Data Source: BioPlex,STRINGDB
FKBP5
Tchem
Family: Enzyme
Novelty: 0.00252437
p_int: 0.999676564
p_ni: 0.000323436
Data Source: BioPlex
Publication Statistics
PubMed Score  14.90

PubMed score by year
PubTator Score  20.94

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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