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Tbio
TOM1L1
TOM1-like protein 1

Protein Summary
Description
Probable adapter protein involved in signaling pathways. Interacts with the SH2 and SH3 domains of various signaling proteins when it is phosphorylated. May promote FYN activation, possibly by disrupting intramolecular SH3-dependent interactions (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000348161
  • ENSP00000343901
  • ENSG00000141198
  • ENST00000536554
  • ENSP00000443099
  • ENST00000570371
  • ENSP00000458553
  • ENST00000575333
  • ENSP00000458918
  • ENST00000575882
  • ENSP00000460823

Symbol
  • SRCASM
  • SRCASM
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.92
protein domain
0.85
transcription factor perturbation
0.84
histone modification site profile
0.77
biological process
0.71


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.87   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 229   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.87   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 229   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
target of myb1 like 1 membrane trafficking protein
VGNC:9730
455138
Macaque
target of myb1 like 1 membrane trafficking protein
710262
Mouse
MGI:1919193
71943
Rat
RGD:1562626
287622
Dog
target of myb1 like 1 membrane trafficking protein
VGNC:47708
491093
Species
Name
OMA
EggNOG
Inparanoid
Chimp
target of myb1 like 1 membrane trafficking protein
Macaque
target of myb1 like 1 membrane trafficking protein
Mouse
Rat
Dog
target of myb1 like 1 membrane trafficking protein
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Protein-Protein Interactions (61)
1 – 10 of 61
TOLLIP
Tbio
Novelty: 0.01032371
p_int: 0.999999981
p_ni: 1e-9
p_wrong: 1.8e-8
Score: 0.689
Data Source: BioPlex,STRINGDB
CUEDC1
Tbio
Novelty: 0.14401061
p_int: 0.999999973
p_ni: 2.3e-8
p_wrong: 4e-9
Score: 0.627
Data Source: BioPlex,STRINGDB
MANSC1
Tdark
Novelty: 0.91681036
p_int: 0.99998893
p_ni: 0.000011024
p_wrong: 4.7e-8
Data Source: BioPlex
AGPAT3
Tbio
Family: Enzyme
Novelty: 0.06139822
p_int: 0.99985949
p_ni: 0.000131982
p_wrong: 0.000008529
Score: 0.187
Data Source: BioPlex,STRINGDB
CTLA4
Tclin
Novelty: 0.00012781
p_int: 0.998092793
p_ni: 0.001907206
p_wrong: 1e-9
Data Source: BioPlex
CAV3
Tbio
Novelty: 0.00190092
p_int: 0.979184476
p_ni: 0.000098281
p_wrong: 0.020717243
Score: 0.177
Data Source: BioPlex,STRINGDB
MRPS7
Tbio
Novelty: 0.00153134
p_int: 0.978916076
p_ni: 0.000123985
p_wrong: 0.020959939
Score: 0.179
Data Source: BioPlex,STRINGDB
CAV1
Tbio
Novelty: 0.00035244
p_int: 0.972265692
p_ni: 0.027733429
p_wrong: 8.79e-7
Data Source: BioPlex
PCDHGB4
Tdark
Novelty: 0.25018904
p_int: 0.943125477
p_ni: 0.000080354
p_wrong: 0.056794169
Data Source: BioPlex
TSG101
Tbio
Novelty: 0.00211746
Score: 0.801
Data Source: STRINGDB
Publication Statistics
PubMed Score  12.87

PubMed score by year
PubTator Score  8.62

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer