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Tbio
TIPRL
TIP41-like protein

Protein Summary
Description
May be a allosteric regulator of serine/threonine-protein phosphatase 2A (PP2A). Isoform 1 inhibits catalytic activity of the PP2A(D) core complex in vitro. The PP2A(C):TIPRL complex does not show phosphatase activity. Acts as negative regulator of serine/threonine-protein phosphatase 4 probably by inhibiting the formation of the active PPP4C:PPP4R2 complex; the function is proposed to implicate it in DNA damage response by promoting H2AFX phosphorylated on Ser-140 (gamma-H2AFX). May play a role in the regulation of ATM/ATR signaling pathway controlling DNA replication and repair. TIPRL is an inhibitory regulator of protein phosphatase-2A (PP2A) (see PPP2CA; MIM 176915), PP4 (see PPP4C; MIM 602035), and PP6 (see PPP6C; MIM 612725) (McConnell et al., 2007 [PubMed 17384681]).[supplied by OMIM, Nov 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000367830
  • ENSP00000356804
  • ENSG00000143155
  • ENST00000367833
  • ENSP00000356807

Symbol
  • TIP
  • TIP41
  • TIPRL1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
disease perturbation
0.93
transcription factor binding site profile
0.86
histone modification site profile
0.85
virus perturbation
0.64


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.02   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 215   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.02   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 215   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
3
3
3
90.7
testosterone measurement
2
1
2
11.5
HbA1c measurement
1
1
1
8.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
3
90.7
testosterone measurement
2
11.5
HbA1c measurement
1
8.8
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
TOR signaling pathway regulator
VGNC:1674
457493
Macaque
TOR signaling pathway regulator
699058
Mouse
MGI:1915087
226591
Rat
RGD:1310442
360869
Dog
TOR signaling pathway regulator
VGNC:47383
480084
Species
Name
OMA
EggNOG
Inparanoid
Chimp
TOR signaling pathway regulator
Macaque
TOR signaling pathway regulator
Mouse
Rat
Dog
TOR signaling pathway regulator
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O75663-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (5)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (79)
1 – 10 of 79
PPP4R2
Tbio
Family:  Enzyme
Novelty:  0.15136638
p_int:  0.999789788
p_ni:  0.000210212
Score:  0.746
Data Source:  BioPlex,STRINGDB
FUCA1
Tchem
Family:  Enzyme
Novelty:  0.00961721
p_int:  0.966179706
p_ni:  0.033820283
p_wrong:  1.1e-8
Score:  0.29
Data Source:  BioPlex,STRINGDB
ITLN1
Tbio
Novelty:  0.00299735
p_int:  0.807496517
p_ni:  0.192503449
p_wrong:  3.4e-8
Score:  0.29
Data Source:  BioPlex,STRINGDB
IGBP1
Tbio
Novelty:  0.00288273
Score:  0.978
Data Source:  STRINGDB
PPP4C
Tbio
Family:  Enzyme
Novelty:  0.00705824
Score:  0.939
Data Source:  STRINGDB
PPP6C
Tbio
Family:  Enzyme
Novelty:  0.00230341
Score:  0.934
Data Source:  STRINGDB
PPP2R1A
Tbio
Family:  Enzyme
Novelty:  0.01134139
Score:  0.912
Data Source:  STRINGDB
MCMBP
Tbio
Novelty:  0.13330215
Score:  0.872
Data Source:  STRINGDB
PPP2CA
Tchem
Family:  Enzyme
Novelty:  0.00496839
Score:  0.872
Data Source:  STRINGDB
TPP2
Tchem
Family:  Enzyme
Novelty:  0.00803674
Score:  0.871
Data Source:  STRINGDB
Publication Statistics
PubMed Score  55.02

PubMed score by year
PubTator Score  1086.15

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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