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Tbio
TRMU
Mitochondrial tRNA-specific 2-thiouridylase 1

Protein Summary
Description
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). Required for the formation of 5-taurinomethyl-2-thiouridine (tm5s2U) of mitochondrial tRNA(Lys), tRNA(Glu), and tRNA(Gln) at the wobble position. ATP is required to activate the C2 atom of the wobble base. This nuclear gene encodes a mitochondrial tRNA-modifying enzyme. The encoded protein catalyzes the 2-thiolation of uridine on the wobble positions of tRNA(Lys), tRNA(Glu), and tRNA(Gln), resulting in the formation of 5-taurinomethyl-2-thiouridine moieties. Mutations in this gene may cause transient infantile liver failure. Polymorphisms in this gene may also influence the severity of deafness caused by mitochondrial 12S ribosomal RNA mutations. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000290846
  • ENSP00000290846
  • ENSG00000100416
  • ENST00000381019
  • ENSP00000370407
  • ENST00000457572
  • ENSP00000407700
  • ENST00000645190
  • ENSP00000496496

Symbol
  • MTU1
  • TRMT1
  • MTO2
  • MTU1
  • TRMT
  • LCAL3
  • TRMT1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.9
tissue sample
0.68
small molecule perturbation
0.64
virus perturbation
0.64
cell type or tissue
0.6


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 64.76   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 167   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 64.76   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 167   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (3)
Metabolism of RNA (R-HSA-8953854)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
tRNA modification in the mitochondrion
Reactome
tRNA processing
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
tRNA modification in the mitochondrion
tRNA processing
Gene Ontology Terms (6)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (144)
1 – 10 of 144
MBL2
Tbio
Novelty: 0.00124156
p_int: 0.999999821
p_ni: 8.2e-8
p_wrong: 9.7e-8
Data Source: BioPlex
FAM219B
Tdark
Novelty: 5.26378794
p_int: 0.999999098
p_ni: 8.34e-7
p_wrong: 6.9e-8
Score: 0.507
Data Source: BioPlex,STRINGDB
THUMPD3
Tdark
Novelty: 0.23224828
p_int: 0.99999306
p_ni: 0.000004161
p_wrong: 0.000002779
Score: 0.445
Data Source: BioPlex,STRINGDB
HSPD1
Tbio
Novelty: 0.00018924
p_int: 0.999981638
p_ni: 0.000018336
p_wrong: 2.6e-8
Score: 0.262
Data Source: BioPlex,STRINGDB
IL1R2
Tbio
Novelty: 0.00820359
p_int: 0.999910981
p_ni: 0.000037765
p_wrong: 0.000051254
Data Source: BioPlex
HOXC10
Tbio
Family: TF
Novelty: 0.02817778
p_int: 0.999885982
p_ni: 0.000045949
p_wrong: 0.000068069
Score: 0.309
Data Source: BioPlex,STRINGDB
GPSM3
Tbio
Novelty: 0.01632501
p_int: 0.999775412
p_ni: 0.000214152
p_wrong: 0.000010436
Data Source: BioPlex
YBEY
Tdark
Family: Enzyme
Novelty: 0.02778029
p_int: 0.999569314
p_ni: 0.000047476
p_wrong: 0.00038321
Score: 0.345
Data Source: BioPlex,STRINGDB
CARTPT
Tbio
Novelty: 0.00224864
p_int: 0.998089884
p_ni: 0.00168422
p_wrong: 0.000225896
Data Source: BioPlex
RNF181
Tbio
Family: Enzyme
Novelty: 0.27482636
p_int: 0.980191782
p_ni: 0.016426909
p_wrong: 0.003381309
Data Source: BioPlex
Publication Statistics
PubMed Score  64.76

PubMed score by year
PubTator Score  24.6

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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