Tbio CTAG2 Cancer/testis antigen 2

Protein Summary

Description

This gene encodes an autoimmunogenic tumor antigen that belongs to the ESO/LAGE family of cancer-testis antigens. This protein is expressed in a wide array of cancers including melanoma, breast cancer, bladder cancer and prostate cancer. This protein is also expressed in normal testis tissue. An alternative open reading frame product of this gene has been described in PMID:10399963. This alternate protein, termed CAMEL, is a tumor antigen that is recognized by melanoma-specific cytotoxic T-lymphocytes. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

Uniprot Accession IDs

• O75638
• O75637
• Q0VIL6
• Q14CD6
• Q2Z1N4
• Q9BU80
• Q9UJ89
• Q9Y479
• CT2

Gene Name

• CTAG2

Ensembl ID

• ENST00000247306
• ENSP00000247306
• ENSG00000126890
• ENST00000369585
• ENSP00000358598

Symbol

• ESO2
• LAGE1
• CT2
• ESO2
• CAMEL
• CT6.2
• CT6.2a
• CT6.2b
• LAGE-1
• LAGE2B

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cellular component	0.59
cell type or tissue	0.58
tissue	0.47
tissue sample	0.47
biological term	0.46

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.55   (req: < 5)

Gene RIFs: 15   (req: <= 3)

Antibodies: 140   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.55   (req: >= 5)

Gene RIFs: 15   (req: > 3)

Antibodies: 140   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

GWAS Traits (4)

• Explore on Target Illumination GWAS Analytics (TIGA)

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1 – 4 of 4

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
HbA1c measurement	EFO_0004541	2	2	2		88.8
lymphocyte percentage of leukocytes	EFO_0007993	1	1	1		30.2
type I diabetes mellitus	EFO_0001359	1	1	0	1.2	26.6
mean corpuscular volume	EFO_0004526	1	1	1		6.4

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 4 of 4

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
HbA1c measurement	EFO_0004541	2		88.8
lymphocyte percentage of leukocytes	EFO_0007993	1		30.2
type I diabetes mellitus	EFO_0001359	0	1.2	26.6
mean corpuscular volume	EFO_0004526	1		6.4

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Protein Structure (0 Structures, 1 AlphaFold Model)

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Representation

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Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

AF-O75638-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (1)

Components (1)

Find Similar Targets

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10

1 – 1 of 1

GO Term	Evidence	Assigned by
centrosome	Inferred from Direct Assay (IDA)	LIFEdb

Protein-Protein Interactions (60)

Explore Interacting Targets

1 – 10 of 60

• See Interactions on String-DB

ADD2

Tbio

Family:  Enzyme

Novelty:  0.01097975

p_int:  0.99999978

p_ni:  2.2e-7

Data Source:  BioPlex

SEC23IP

Tbio

Novelty:  0.0925721

p_int:  0.999999737

p_ni:  2.63e-7

Data Source:  BioPlex

FLCN

Tbio

Novelty:  0.0022007

p_int:  0.999997128

p_ni:  0.000002871

p_wrong:  1e-9

Data Source:  BioPlex

TBC1D9B

Tdark

Novelty:  0.66719861

p_int:  0.999981446

p_ni:  0.000018549

p_wrong:  5e-9

Data Source:  BioPlex

PCNT

Tbio

Novelty:  0.00369505

p_int:  0.999959888

p_ni:  0.000040112

Score:  0.435

Data Source:  BioPlex,STRINGDB

TBC1D9

Tbio

Novelty:  0.20059899

p_int:  0.999900636

p_ni:  0.000099338

p_wrong:  2.6e-8

Data Source:  BioPlex

MELK

Tchem

Family:  Kinase

Novelty:  0.00762154

p_int:  0.999568637

p_ni:  0.000431363

Data Source:  BioPlex

RNF31

Tbio

Family:  Enzyme

Novelty:  0.01394304

p_int:  0.994994102

p_ni:  0.004919017

p_wrong:  0.000086881

Data Source:  BioPlex

CDK5RAP2

Tbio

Novelty:  0.00956263

p_int:  0.986999303

p_ni:  0.01300063

p_wrong:  6.6e-8

Data Source:  BioPlex

SASS6

Tbio

Novelty:  0.00680548

p_int:  0.986351943

p_ni:  0.012508104

p_wrong:  0.001139953

Data Source:  BioPlex

Publication Statistics

PubMed Score  30.55

PubMed score by year

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PubTator Score  203.11

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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Alternative splicing
Complete proteome
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GWAS Trait Find Similar Targets

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HbA1c measurement
lymphocyte percentage of leukocytes
mean corpuscular volume
type I diabetes mellitus