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Tbio
CTAG2
Cancer/testis antigen 2

Protein Summary
Description
This gene encodes an autoimmunogenic tumor antigen that belongs to the ESO/LAGE family of cancer-testis antigens. This protein is expressed in a wide array of cancers including melanoma, breast cancer, bladder cancer and prostate cancer. This protein is also expressed in normal testis tissue. An alternative open reading frame product of this gene has been described in PMID:10399963. This alternate protein, termed CAMEL, is a tumor antigen that is recognized by melanoma-specific cytotoxic T-lymphocytes. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000247306
  • ENSP00000247306
  • ENSG00000126890
  • ENST00000369585
  • ENSP00000358598

Symbol
  • ESO2
  • LAGE1
  • CT2
  • ESO2
  • CAMEL
  • CT6.2
  • CT6.2a
  • CT6.2b
  • LAGE-1
  • LAGE2B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.59
cell type or tissue
0.58
tissue
0.47
tissue sample
0.47
biological term
0.46


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.55   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 140   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.55   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 140   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
HbA1c measurement
2
2
2
88.8
lymphocyte percentage of leukocytes
1
1
1
30.2
1
1
0
1.2
26.6
mean corpuscular volume
1
1
1
6.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
HbA1c measurement
2
88.8
lymphocyte percentage of leukocytes
1
30.2
0
1.2
26.6
mean corpuscular volume
1
6.4
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O75638-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (1)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
LIFEdb
Protein-Protein Interactions (60)
1 – 10 of 60
ADD2
Tbio
Family:  Enzyme
Novelty:  0.01097975
p_int:  0.99999978
p_ni:  2.2e-7
Data Source:  BioPlex
SEC23IP
Tbio
Novelty:  0.0925721
p_int:  0.999999737
p_ni:  2.63e-7
Data Source:  BioPlex
FLCN
Tbio
Novelty:  0.0022007
p_int:  0.999997128
p_ni:  0.000002871
p_wrong:  1e-9
Data Source:  BioPlex
TBC1D9B
Tdark
Novelty:  0.66719861
p_int:  0.999981446
p_ni:  0.000018549
p_wrong:  5e-9
Data Source:  BioPlex
PCNT
Tbio
Novelty:  0.00369505
p_int:  0.999959888
p_ni:  0.000040112
Score:  0.435
Data Source:  BioPlex,STRINGDB
TBC1D9
Tbio
Novelty:  0.20059899
p_int:  0.999900636
p_ni:  0.000099338
p_wrong:  2.6e-8
Data Source:  BioPlex
MELK
Tchem
Family:  Kinase
Novelty:  0.00762154
p_int:  0.999568637
p_ni:  0.000431363
Data Source:  BioPlex
RNF31
Tbio
Family:  Enzyme
Novelty:  0.01394304
p_int:  0.994994102
p_ni:  0.004919017
p_wrong:  0.000086881
Data Source:  BioPlex
CDK5RAP2
Tbio
Novelty:  0.00956263
p_int:  0.986999303
p_ni:  0.01300063
p_wrong:  6.6e-8
Data Source:  BioPlex
SASS6
Tbio
Novelty:  0.00680548
p_int:  0.986351943
p_ni:  0.012508104
p_wrong:  0.001139953
Data Source:  BioPlex
Publication Statistics
PubMed Score  30.55

PubMed score by year
PubTator Score  203.11

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer