Tbio FCN3 Ficolin-3

Protein Summary

Description

May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent and GlcNAc-binding lectin. Has affinity with GalNAc, GlcNAc, D-fucose, as mono/oligosaccharide and lipopolysaccharides from S.typhimurium and S.minnesota. Ficolins are a group of proteins which consist of a collagen-like domain and a fibrinogen-like domain. In human serum, there are two types of ficolins, both of which have lectin activity. The protein encoded by this gene is a thermolabile beta-2-macroglycoprotein found in all human serum and is a member of the ficolin/opsonin p35 lectin family. The protein, which was initially identified based on its reactivity with sera from patients with systemic lupus erythematosus, has been shown to have a calcium-independent lectin activity. The protein can activate the complement pathway in association with MASPs and sMAP, thereby aiding in host defense through the activation of the lectin pathway. Alternative splicing occurs at this locus and two variants, each encoding a distinct isoform, have been identified. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O75636
• Q6IBJ5
• Q8WW86

Gene Name

• FCN3

Ensembl ID

• ENST00000270879
• ENSP00000270879
• ENSG00000142748
• ENST00000354982
• ENSP00000347077

Symbol

• FCNH
• HAKA1
• FCNH
• HAKA1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.73
tissue sample	0.65
biological process	0.58
biological term	0.53
tissue	0.47

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Ficolin-3

DTO Classes

Protein / Signaling / Ficolin-3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 156.76   (req: < 5)

Gene RIFs: 59   (req: <= 3)

Antibodies: 227   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 156.76   (req: >= 5)

Gene RIFs: 59   (req: > 3)

Antibodies: 227   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0