You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
ERAL1
GTPase Era, mitochondrial

Protein Summary
Description
Probable GTPase that plays a role in the mitochondrial ribosomal small subunit assembly. Specifically binds the 12S mitochondrial rRNA (12S mt-rRNA) to a 33 nucleotide section delineating the 3' terminal stem-loop region. May act as a chaperone that protects the 12S mt-rRNA on the 28S mitoribosomal subunit during ribosomal small subunit assembly. The protein encoded by this gene is a GTPase that localizes to the mitochondrion. The encoded protein binds to the 3' terminal stem loop of 12S mitochondrial rRNA and is required for proper assembly of the 28S small mitochondrial ribosomal subunit. Deletion of this gene has been shown to cause mitochondrial dysfunction, growth retardation, and apoptosis. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000254928
  • ENSP00000254928
  • ENSG00000132591

Symbol
  • HERA
  • ERA
  • CEGA
  • ERA-W
  • H-ERA
  • ERAL1A
  • ERAL1B
  • HERA-A
  • HERA-B
  • PRLTS6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.95
protein domain
0.92
histone modification site profile
0.91
molecular function
0.91
interacting protein
0.87


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 59.48   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 201   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 59.48   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 201   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
5
5
5
98.9
red blood cell distribution width
4
4
4
98.8
reticulocyte count
4
3
4
94
reticulocyte measurement
2
2
2
89.1
hemoglobin measurement
2
2
2
84.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
5
98.9
red blood cell distribution width
4
98.8
reticulocyte count
4
94
reticulocyte measurement
2
89.1
hemoglobin measurement
2
84.3
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Era like 12S mitochondrial rRNA chaperone 1
VGNC:9425
454536
Macaque
Era like 12S mitochondrial rRNA chaperone 1
716483
Mouse
MGI:1889295
57837
Rat
RGD:1304714
363646
Dog
Era like 12S mitochondrial rRNA chaperone 1
VGNC:40432
480629
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Era like 12S mitochondrial rRNA chaperone 1
Macaque
Era like 12S mitochondrial rRNA chaperone 1
Mouse
Rat
Dog
Era like 12S mitochondrial rRNA chaperone 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O75616-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (7)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Mitochondrial translation
Reactome
Mitochondrial translation elongation
Reactome
Mitochondrial translation initiation
Reactome
Mitochondrial translation termination
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Mitochondrial translation
Mitochondrial translation elongation
Mitochondrial translation initiation
Mitochondrial translation termination
Gene Ontology Terms (11)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (160)
1 – 10 of 160
COL1A2
Tbio
Novelty:  0.00048334
p_int:  0.99999197
p_ni:  4.06e-7
p_wrong:  0.000007624
Score:  0.309
Data Source:  BioPlex,STRINGDB
COL1A1
Tbio
Novelty:  0.00063584
p_int:  0.998085454
p_ni:  0.001914541
p_wrong:  5e-9
Score:  0.188
Data Source:  BioPlex,STRINGDB
ATPAF1
Tbio
Family:  Enzyme
Novelty:  0.04032579
p_int:  0.951473988
p_ni:  0.048526012
Score:  0.513
Data Source:  BioPlex,STRINGDB
MRPS17
Tdark
Novelty:  0.46103276
p_int:  0.895285676
p_ni:  0.104714324
Score:  0.21
Data Source:  BioPlex,STRINGDB
HNRNPDL
Tbio
Novelty:  0.00222179
p_int:  0.828767198
p_ni:  0.171232802
Score:  0.53
Data Source:  BioPlex,STRINGDB
ZNF777
Tdark
Family:  TF
Novelty:  1.20195224
p_int:  0.818318761
p_ni:  0.181681239
Data Source:  BioPlex
LRP1
Tbio
Novelty:  0.00200788
p_int:  0.787488876
p_ni:  0.212511124
Data Source:  BioPlex
COL3A1
Tbio
Novelty:  0.00197327
p_int:  0.752029338
p_ni:  0.00000333
p_wrong:  0.247967332
Score:  0.513
Data Source:  BioPlex,STRINGDB
MRRF
Tbio
Novelty:  0.00269663
Score:  0.974
Data Source:  STRINGDB
MRPL58
Tbio
Family:  Enzyme
Novelty:  0.00178011
Score:  0.972
Data Source:  STRINGDB
Publication Statistics
PubMed Score  59.48

PubMed score by year
PubTator Score  3255.41

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: