Tbio ERAL1 GTPase Era, mitochondrial

Protein Summary

Description

Probable GTPase that plays a role in the mitochondrial ribosomal small subunit assembly. Specifically binds the 12S mitochondrial rRNA (12S mt-rRNA) to a 33 nucleotide section delineating the 3' terminal stem-loop region. May act as a chaperone that protects the 12S mt-rRNA on the 28S mitoribosomal subunit during ribosomal small subunit assembly. The protein encoded by this gene is a GTPase that localizes to the mitochondrion. The encoded protein binds to the 3' terminal stem loop of 12S mitochondrial rRNA and is required for proper assembly of the 28S small mitochondrial ribosomal subunit. Deletion of this gene has been shown to cause mitochondrial dysfunction, growth retardation, and apoptosis. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]

Uniprot Accession IDs

• O75616
• B3KN21
• C9JEC6
• O75617
• Q8WUY4
• Q96LE2
• Q96TC0
• H-ERA

Gene Name

• ERAL1

Ensembl ID

• ENST00000254928
• ENSP00000254928
• ENSG00000132591

Symbol

• HERA
• ERA
• CEGA
• ERA-W
• H-ERA
• ERAL1A
• ERAL1B
• HERA-A
• HERA-B
• PRLTS6

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.95
protein domain	0.92
histone modification site profile	0.91
molecular function	0.91
interacting protein	0.87

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / G-protein / Small Gtpase / Gtpase Era, Mitochondrial

DTO Classes

Protein / Enzyme Modulator / G-protein / Small Gtpase / Gtpase Era, Mitochondrial

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 455.41   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 201   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 455.41   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 201   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0