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Tchem
LYPLA1
Acyl-protein thioesterase 1

Protein Summary
Description
Hydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS. Has depalmitoylating activity toward KCNMA1. Has low lysophospholipase activity. This gene encodes a member of the alpha/beta hydrolase superfamily. The encoded protein functions as a homodimer, exhibiting both depalmitoylating as well as lysophospholipase activity, and may be involved in Ras localization and signaling. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene have been defined on chromosomes 4, 6, and 7. [provided by RefSeq, Jul 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000316963
  • ENSP00000320043
  • ENSG00000120992
  • ENST00000343231
  • ENSP00000344477

Symbol
  • APT1
  • LPL1
  • APT1
  • LPL1
  • APT-1
  • LPL-I
  • hAPT1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
virus perturbation
0.9
gene perturbation
0.81
interacting protein
0.77
metabolite
0.75


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 87.22   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 286   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 87.22   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 286   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 7
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
lysophospholipase I
693700
Mouse
MGI:1344588
18777
Rat
RGD:3025
25514
Dog
lysophospholipase I
VGNC:42890
609018
Horse
lysophospholipase I [Source:HGNC Symbol;Acc:HGNC:6737]
Species
Name
OMA
EggNOG
Inparanoid
Macaque
lysophospholipase I
Mouse
Rat
Dog
lysophospholipase I
Horse
lysophospholipase I [Source:HGNC Symbol;Acc:HGNC:6737]
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O75608-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (5)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of nitric oxide: eNOS activation and regulation
Reactome
eNOS activation
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of nitric oxide: eNOS activation and regulation
eNOS activation
Protein-Protein Interactions (125)
1 – 10 of 125
TRIM11
Tbio
Family: Enzyme
Novelty: 0.02243955
p_int: 0.999856072
p_ni: 0.000143928
Data Source: BioPlex
CTSO
Tbio
Family: Enzyme
Novelty: 0.09963965
p_int: 0.999749531
p_ni: 0.000184712
p_wrong: 0.000065758
Score: 0.517
Data Source: BioPlex,STRINGDB
TEAD4
Tbio
Family: TF
Novelty: 0.0114979
p_int: 0.994353418
p_ni: 0.005630099
p_wrong: 0.000016482
Score: 0.228
Data Source: BioPlex,STRINGDB
USP47
Tchem
Family: Enzyme
Novelty: 0.07579226
p_int: 0.988325753
p_ni: 0.011531866
p_wrong: 0.000142381
Data Source: BioPlex
GTF2E2
Tbio
Novelty: 0.18033153
p_int: 0.986984862
p_ni: 0.012948987
p_wrong: 0.000066152
Data Source: BioPlex
MTRF1
Tbio
Family: Enzyme
Novelty: 0.11037387
p_int: 0.89644456
p_ni: 0.09982255
p_wrong: 0.00373289
Data Source: BioPlex
FCF1
Tdark
Novelty: 0.04202976
p_int: 0.852644907
p_ni: 0.081237414
p_wrong: 0.066117679
Data Source: BioPlex
NOS3
Tchem
Family: Enzyme
Novelty: 0.00012407
Score: 0.923
Data Source: Reactome,STRINGDB
GPCPD1
Tdark
Family: Enzyme
Novelty: 0.03548168
Score: 0.918
Data Source: STRINGDB
LCAT
Tbio
Family: Enzyme
Novelty: 0.00307544
Score: 0.914
Data Source: STRINGDB
Publication Statistics
PubMed Score  87.22

PubMed score by year
PubTator Score  75.66

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer