Tchem LYPLA1 Acyl-protein thioesterase 1

Protein Summary

Description

Hydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS. Has depalmitoylating activity toward KCNMA1. Has low lysophospholipase activity. This gene encodes a member of the alpha/beta hydrolase superfamily. The encoded protein functions as a homodimer, exhibiting both depalmitoylating as well as lysophospholipase activity, and may be involved in Ras localization and signaling. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene have been defined on chromosomes 4, 6, and 7. [provided by RefSeq, Jul 2013]

Uniprot Accession IDs

• O75608
• O43202
• Q9UQF9
• APT-1

Gene Name

• LYPLA1

Ensembl ID

• ENST00000316963
• ENSP00000320043
• ENSG00000120992
• ENST00000343231
• ENSP00000344477

Symbol

• APT1
• LPL1
• APT1
• LPL1
• APT-1
• LPL-I
• hAPT1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
co-expressed gene	1
virus perturbation	0.9
gene perturbation	0.81
interacting protein	0.77
metabolite	0.75

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 110.67   (req: < 5)

Gene RIFs: 13   (req: <= 3)

Antibodies: 286   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 110.67   (req: >= 5)

Gene RIFs: 13   (req: > 3)

Antibodies: 286   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 7

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0