Tbio NPM3 Nucleoplasmin-3

Protein Classes

PANTHER Classes

Protein / Chaperone / Nucleoplasmin-3

Protein Summary

Description

May act as a chaperone. The protein encoded by this gene is related to the nuclear chaperone phosphoproteins, nucleoplasmin and nucleophosmin. This protein is strongly expressed in diverse cell types where it localizes primarily to the nucleus. Based on its similarity to nucleoplasmin and nucleophosmin, this protein likely functions as a molecular chaperone in the cell nucleus. [provided by RefSeq, Oct 2008]

Uniprot Accession IDs

• O75607
• Q9UNY6

Gene Name

• NPM3

Ensembl ID

• ENST00000370110
• ENSP00000359128
• ENSG00000107833

Symbol

• PORMIN
• TMEM123

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.77
small molecule perturbation	0.75
drug perturbation	0.71
PubMedID	0.69
tissue sample	0.68

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.13   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 113   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.13   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 113   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Gene Ontology Terms (11)

Functions (3)

Components (5)

Processes (3)

Items per page:

10

1 – 3 of 3

GO Term	Evidence	Assigned by
RNA binding	Inferred from High Throughput Direct Assay (HDA)	UniProtKB
chromatin binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
histone binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

Protein-Protein Interactions (39)

Explore Interacting Targets

1 – 10 of 39

• See Interactions on String-DB

NPM1

Tbio

Novelty: 0.00069185

p_int: 0.98504155

p_ni: 0.014957366

p_wrong: 0.000001083

Score: 0.741

Data Source: BioPlex,STRINGDB

NPM2

Tbio

Novelty: 0.05245308

p_int: 0.984036617

p_ni: 0.015566099

p_wrong: 0.000397284

Score: 0.993

Data Source: BioPlex,STRINGDB

FKBP15

Tbio

Novelty: 0.07897873

Score: 0.848

Data Source: STRINGDB

EEF1D

Tbio

Novelty: 0.0317015

Score: 0.689

Data Source: STRINGDB

DUT

Tchem

Family: Enzyme

Novelty: 0.003979

Score: 0.686

Data Source: STRINGDB

H2AFZ

Tbio

Novelty: 0.00281312

Score: 0.662

Data Source: STRINGDB

H2AFV

Tbio

Novelty: 0.06257527

Score: 0.645

Data Source: STRINGDB

TRIM55

Tbio

Novelty: 0.09248041

Score: 0.626

Data Source: STRINGDB

CHD1

Tbio

Family: Epigenetic

Novelty: 0.00683301

Score: 0.625

Data Source: STRINGDB

FGF8

Tbio

Novelty: 0.00182042

Score: 0.615

Data Source: STRINGDB

Publication Statistics

PubMed Score  5.13

PubMed score by year

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PubTator Score  6.64

PubTator score by year

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Amino Acid Sequence

Residue Counts

Sequence

MAAGTAAALAFLSQESRTRAGGVGGLRVPAPVTMDSFFFGCELSGHTRSFTFKVEEEDDAEHVLALTMLC

1-70

LTEGAKDECNVVEVVARNHDHQEIAVPVANLKLSCQPMLSLDDFQLQPPVTFRLKSGSGPVRITGRHQIV

70-140

TMSNDVSEEESEEEEEDSDEEEVELCPILPAKKQGGRP

140-178

MAAGTAAALAFLSQESRTRAGGVGGLRVPAPVTMDSFFFGCELSGHTRSFTFKVEEEDDAEHVLALTMLCLTEGAKDECNVVEVVARNHDHQEIAVPVANLKLSCQPMLSLDDFQLQPPVTFRLKSGSGPVRITGRHQIVTMSNDVSEEESEEEEEDSDEEEVELCPILPAKKQGGRP

Find similar targets by:

Uniprot Keyword

Acetylation
Chaperone
Complete proteome
Direct protein sequencing
Methylation
Nucleus
Phosphoprotein
Polymorphism
Reference proteome