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Tbio
NPM3
Nucleoplasmin-3

Protein Classes
Protein Summary
Description
May act as a chaperone. The protein encoded by this gene is related to the nuclear chaperone phosphoproteins, nucleoplasmin and nucleophosmin. This protein is strongly expressed in diverse cell types where it localizes primarily to the nucleus. Based on its similarity to nucleoplasmin and nucleophosmin, this protein likely functions as a molecular chaperone in the cell nucleus. [provided by RefSeq, Oct 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000370110
  • ENSP00000359128
  • ENSG00000107833

Symbol
  • PORMIN
  • TMEM123
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.77
small molecule perturbation
0.75
drug perturbation
0.71
PubMedID
0.69
tissue sample
0.68


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.61   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 113   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.61   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 113   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
nucleophosmin/nucleoplasmin 3
VGNC:5583
450690
Macaque
nucleophosmin/nucleoplasmin 3
712300
Mouse
MGI:894653
18150
Rat
RGD:1565542
502389
Dog
nucleophosmin/nucleoplasmin 3
VGNC:43923
477801
Species
Name
OMA
EggNOG
Inparanoid
Chimp
nucleophosmin/nucleoplasmin 3
Macaque
nucleophosmin/nucleoplasmin 3
Mouse
Rat
Dog
nucleophosmin/nucleoplasmin 3
Gene Ontology Terms (11)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (39)
1 – 10 of 39
NPM1
Tbio
Novelty: 0.0005485
p_int: 0.98504155
p_ni: 0.014957366
p_wrong: 0.000001083
Score: 0.741
Data Source: BioPlex,STRINGDB
NPM2
Tbio
Novelty: 0.03674672
p_int: 0.984036617
p_ni: 0.015566099
p_wrong: 0.000397284
Score: 0.993
Data Source: BioPlex,STRINGDB
FKBP15
Tbio
Novelty: 0.0570695
Score: 0.848
Data Source: STRINGDB
EEF1D
Tbio
Novelty: 0.02480745
Score: 0.689
Data Source: STRINGDB
DUT
Tchem
Family: Enzyme
Novelty: 0.0026993
Score: 0.686
Data Source: STRINGDB
H2AFZ
Tbio
Novelty: 0.00222512
Score: 0.662
Data Source: STRINGDB
H2AFV
Tbio
Novelty: 0.03561635
Score: 0.645
Data Source: STRINGDB
TRIM55
Tbio
Novelty: 0.06290418
Score: 0.626
Data Source: STRINGDB
CHD1
Tbio
Family: Epigenetic
Novelty: 0.00498132
Score: 0.625
Data Source: STRINGDB
FGF8
Tbio
Novelty: 0.00155113
Score: 0.615
Data Source: STRINGDB
Publication Statistics
PubMed Score  8.61

PubMed score by year
PubTator Score  6.64

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer