Tbio NPM3 Nucleoplasmin-3

Protein Summary

Description

May act as a chaperone. The protein encoded by this gene is related to the nuclear chaperone phosphoproteins, nucleoplasmin and nucleophosmin. This protein is strongly expressed in diverse cell types where it localizes primarily to the nucleus. Based on its similarity to nucleoplasmin and nucleophosmin, this protein likely functions as a molecular chaperone in the cell nucleus. [provided by RefSeq, Oct 2008]

Uniprot Accession IDs

• O75607
• Q9UNY6

Gene Name

• NPM3

Ensembl ID

• ENST00000370110
• ENSP00000359128
• ENSG00000107833

Symbol

• PORMIN
• TMEM123

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.77
small molecule perturbation	0.75
drug perturbation	0.71
PubMedID	0.69
tissue sample	0.68

Protein Classes

PANTHER Classes

Protein / Chaperone / Nucleoplasmin-3

DTO Classes

Protein / Chaperone / Nucleoplasmin-3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.28   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 113   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.28   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 113   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0