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Tbio
PGLYRP1
Peptidoglycan recognition protein 1

Protein Summary
Description
Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. Has bactericidal activity towards Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Binds also to Gram-negative bacteria, and has bacteriostatic activity towards Gram-negative bacteria. Plays a role in innate immunity.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000008938
  • ENSP00000008938
  • ENSG00000008438

Symbol
  • PGLYRP
  • PGRP
  • TNFSF3L
  • PGRP
  • TAG7
  • PGRPS
  • PGLYRP
  • PGRP-S
  • TNFSF3L
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.76
molecular function
0.76
disease perturbation
0.74
gene perturbation
0.67
protein domain
0.58


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 499.73   (req: < 5)
Gene RIFs: 25   (req: <= 3)
Antibodies: 343   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 499.73   (req: >= 5)
Gene RIFs: 25   (req: > 3)
Antibodies: 343   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
peptidoglycan recognition protein 1
VGNC:2289
468926
Macaque
peptidoglycan recognition protein 1
718480
Mouse
MGI:1345092
21946
Rat
RGD:621429
84387
Dog
peptidoglycan recognition protein 1
VGNC:44461
612209
Species
Name
OMA
EggNOG
Inparanoid
Chimp
peptidoglycan recognition protein 1
Macaque
peptidoglycan recognition protein 1
Mouse
Rat
Dog
peptidoglycan recognition protein 1
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O75594-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (4)
Antimicrobial peptides (R-HSA-6803157)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Antimicrobial peptides
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Antimicrobial peptides
Immune System
Innate Immune System
Neutrophil degranulation
Protein-Protein Interactions (118)
1 – 10 of 118
IFNA2
Tbio
Novelty: 0.00032935
p_int: 0.992465304
p_ni: 0.007251264
p_wrong: 0.000283432
Score: 0.53
Data Source: BioPlex,STRINGDB
CNRIP1
Tbio
Novelty: 0.06888531
p_int: 0.89799899
p_ni: 0.101998752
p_wrong: 0.000002258
Score: 0.54
Data Source: BioPlex,STRINGDB
CAMP
Tbio
Novelty: 0.00064433
Score: 0.968
Data Source: STRINGDB
DEFA4
Tbio
Novelty: 0.04566082
Score: 0.964
Data Source: STRINGDB
BPI
Tbio
Novelty: 0.00229665
Score: 0.96
Data Source: STRINGDB
LTF
Tbio
Novelty: 0.00114254
Score: 0.951
Data Source: STRINGDB
LCN2
Tbio
Family: Enzyme
Novelty: 0.00034678
Score: 0.934
Data Source: STRINGDB
ELANE
Tclin
Family: Enzyme
Novelty: 0.00026112
Score: 0.932
Data Source: STRINGDB
TOLLIP
Tbio
Novelty: 0.01032371
Score: 0.932
Data Source: STRINGDB
RETN
Tbio
Novelty: 0.00062517
Score: 0.931
Data Source: STRINGDB
Publication Statistics
PubMed Score  499.73

PubMed score by year
PubTator Score  74.21

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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