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Tbio
FOXH1
Forkhead box protein H1

Protein Summary
Description
Transcriptional activator. Recognizes and binds to the DNA sequence 5'-TGT[GT][GT]ATT-3'. Required for induction of the goosecoid (GSC) promoter by TGF-beta or activin signaling. Forms a transcriptionally active complex containing FOXH1/SMAD2/SMAD4 on a site on the GSC promoter called TARE (TGF-beta/activin response element). FOXH1 encodes a human homolog of Xenopus forkhead activin signal transducer-1. FOXH1 protein binds SMAD2 and activates an activin response element via binding the DNA motif TGT(G/T)(T/G)ATT. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000377317
  • ENSP00000366534
  • ENSG00000160973

Symbol
  • FAST1
  • FAST2
  • FAST1
  • FAST-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.97
biological process
0.92
cellular component
0.71
transcription factor binding site profile
0.66
gene perturbation
0.6


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 129.1   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 230   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 129.1   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 230   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 29
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
1
1
1
58.6
self reported educational attainment
1
1
1
57.4
cognitive function measurement
1
1
1
47.8
blood metabolite measurement
1
1
4
13.8
smoking status measurement
1
1
1
11.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
1
58.6
self reported educational attainment
1
57.4
cognitive function measurement
1
47.8
blood metabolite measurement
4
13.8
smoking status measurement
1
11.2
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
forkhead box H1
VGNC:12013
464468
Macaque
forkhead box H1
714987
Mouse
MGI:1347465
14106
Rat
RGD:1311275
300054
Dog
forkhead box H1
VGNC:51772
482098
Species
Name
OMA
EggNOG
Inparanoid
Chimp
forkhead box H1
Macaque
forkhead box H1
Mouse
Rat
Dog
forkhead box H1
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O75593-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (13)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Signal Transduction
Reactome
Signaling by Activin
Reactome
Signaling by NODAL
Reactome
Signaling by TGF-beta family members
Name
Explore in Pharos
Explore in Source
Developmental Biology
Signal Transduction
Signaling by Activin
Signaling by NODAL
Signaling by TGF-beta family members
Gene Ontology Terms (34)
Items per page:
10
1 – 10 of 12
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Mutant Phenotype (IMP)
BHF-UCL
Inferred from Mutant Phenotype (IMP)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence Alignment (ISA)
NTNU_SB
Non-traceable Author Statement (NAS)
BHF-UCL
Protein-Protein Interactions (66)
1 – 10 of 66
SMAD2
Tbio
Family: TF
Novelty: 0.00040166
Score: 0.991
Data Source: Reactome,STRINGDB
DRAP1
Tbio
Novelty: 0.05872031
Score: 0.984
Data Source: Reactome,STRINGDB
SMAD4
Tbio
Family: TF
Novelty: 0.00047069
Score: 0.978
Data Source: Reactome,STRINGDB
NKX2-5
Tbio
Family: TF
Novelty: 0.00125993
Score: 0.974
Data Source: STRINGDB
SMAD3
Tbio
Family: TF
Novelty: 0.00048058
Score: 0.97
Data Source: Reactome,STRINGDB
EP300
Tchem
Family: Epigenetic
Novelty: 0.00055009
Score: 0.947
Data Source: STRINGDB
DCP1A
Tbio
Novelty: 0.02038933
Score: 0.902
Data Source: STRINGDB
MIXL1
Tbio
Family: TF
Novelty: 0.0196256
Score: 0.835
Data Source: STRINGDB
TDGF1
Tbio
Novelty: 0.00527099
Score: 0.818
Data Source: STRINGDB
CFC1
Tbio
Novelty: 0.01787772
Score: 0.721
Data Source: STRINGDB
Publication Statistics
PubMed Score  129.10

PubMed score by year
PubTator Score  85.44

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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