MED6
Mediator of RNA polymerase II transcription subunit 6
Protein Summary
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
- ENST00000256379
- ENSP00000256379
- ENSG00000133997
- ENST00000430055
- ENSP00000413343
- ENST00000440435
- ENSP00000394502
- ARC33
- ARC33
- NY-REN-28
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
kinase perturbation | 0.97 | ||
histone modification site profile | 0.89 | ||
cell type or tissue | 0.75 | ||
protein complex | 0.72 | ||
hub protein | 0.71 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 25.52 (req: < 5)
Gene RIFs: 2 (req: <= 3)
Antibodies: 275 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 25.52 (req: >= 5)
Gene RIFs: 2 (req: > 3)
Antibodies: 275 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0