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Tchem
RPS6KA5
Ribosomal protein S6 kinase alpha-5

Protein Summary
Description
Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factors RELA, STAT3 and ETV1/ER81, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes (PubMed:11909979, PubMed:12569367, PubMed:12763138, PubMed:9687510, PubMed:18511904, PubMed:9873047). Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin (PubMed:11909979, PubMed:9873047). Plays an essential role in the control of RELA transcriptional activity in response to TNF and upon glucocorticoid, associates in the cytoplasm with the glucocorticoid receptor NR3C1 and contributes to RELA inhibition and repression of inflammatory gene expression (PubMed:12628924, PubMed:18511904). In skeletal myoblasts is required for phosphorylation of RELA at 'Ser-276' ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000418736
  • ENSP00000402787
  • ENSG00000100784
  • ENST00000536315
  • ENSP00000442803
  • ENST00000614987
  • ENSP00000479667

Symbol
  • MSK1
  • MSK1
  • RLPK
  • MSPK1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.98
co-expressed gene
0.97
molecular function
0.97
protein domain
0.97
interacting protein
0.89


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 109.31   (req: < 5)
Gene RIFs: 43   (req: <= 3)
Antibodies: 854   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 109.31   (req: >= 5)
Gene RIFs: 43   (req: > 3)
Antibodies: 854   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 33
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
sunitinib
chemical structure image
Active Ligands (33)
1 – 10 of 33
CHEMBL388978
chemical structure image
CHEMBL2347053
chemical structure image
CHEMBL6291,CHEMBL1591531
chemical structure image
CHEMBL1956071
chemical structure image
CHEMBL2023841
chemical structure image
CHEMBL2023714
chemical structure image
CHEMBL189657
chemical structure image
CHEMBL493911
chemical structure image
CHEMBL188433,CHEMBL189231
chemical structure image
CHEMBL2023845
chemical structure image
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
2
3
95.3
body mass index
2
2
2
92.5
femoral neck bone mineral density
2
2
2
81.3
bone fracture
1
1
0
1.1
76.4
bone density
1
3
3
70.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
95.3
body mass index
2
92.5
femoral neck bone mineral density
2
81.3
bone fracture
0
1.1
76.4
bone density
3
70.5
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (87)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 37
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
C-type lectin receptors (CLRs)
Reactome
CD209 (DC-SIGN) signaling
Reactome
CREB phosphorylation
Reactome
Cytokine Signaling in Immune system
Name
Explore in Pharos
Explore in Source
Axon guidance
C-type lectin receptors (CLRs)
CD209 (DC-SIGN) signaling
CREB phosphorylation
Cytokine Signaling in Immune system
Protein-Protein Interactions (87)
1 – 10 of 87
CHCHD4
Tbio
Novelty: 0.01204944
p_int: 0.999999996
p_ni: 4e-9
Data Source: BioPlex
MAPK14
Tchem
Family: Kinase
Novelty: 0.00045138
p_int: 0.99999934
p_ni: 6.6e-7
Score: 0.963
Data Source: BioPlex,Reactome,STRINGDB
HSP90AA4P
Tdark
p_int: 0.888006954
p_ni: 0.111992488
p_wrong: 5.58e-7
Data Source: BioPlex
CREB1
Tbio
Family: TF
Novelty: 0.00018059
Score: 0.985
Data Source: Reactome,STRINGDB
RELA
Tchem
Family: TF
Novelty: 0.0007137
Score: 0.979
Data Source: Reactome,STRINGDB
ATF1
Tchem
Family: TF
Novelty: 0.01450941
Score: 0.976
Data Source: Reactome,STRINGDB
EIF4EBP1
Tbio
Novelty: 0.00098313
Score: 0.972
Data Source: STRINGDB
MAPK1
Tchem
Family: Kinase
Novelty: 0.00061058
Score: 0.964
Data Source: Reactome,STRINGDB
MAPK11
Tchem
Family: Kinase
Novelty: 0.00545217
Score: 0.963
Data Source: Reactome,STRINGDB
HMGN1
Tbio
Novelty: 0.00492501
Score: 0.96
Data Source: STRINGDB
Publication Statistics
PubMed Score  109.31

PubMed score by year
PubTator Score  90.06

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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