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Tbio
LRP6
Low-density lipoprotein receptor-related protein 6

Protein Summary
Description
Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Required for posterior patterning of the epiblast during gastrulation (By similarity). This gene encodes a member of the low density lipoprotein (LDL) receptor gene family. LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands. The protein encoded by this gene functions as a receptor or, with Frizzled, a co-receptor for Wnt and thereby transmits the canonical Wnt/bet ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261349
  • ENSP00000261349
  • ENSG00000070018
  • ENST00000628182
  • ENSP00000486315
  • ENSG00000281324

Symbol
  • ADCAD2
  • STHAG7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
virus perturbation
0.98
molecular function
0.91
microRNA
0.88
kinase
0.85


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 324.66   (req: < 5)
Gene RIFs: 142   (req: <= 3)
Antibodies: 539   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 324.66   (req: >= 5)
Gene RIFs: 142   (req: > 3)
Antibodies: 539   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 63
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
Items per page:
1 – 5 of 6
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
4
4
94.5
heel bone mineral density
2
4
4
94.5
balding measurement
1
2
2
84.5
balding measurement
1
1
1
78.8
self reported educational attainment
1
1
1
57.1
Items per page:
1 – 5 of 6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
4
94.5
heel bone mineral density
4
94.5
balding measurement
2
84.5
balding measurement
1
78.8
self reported educational attainment
1
57.1
Protein Data Bank (14)
1 – 5 of 14
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (57)
Disassembly of the destruction complex and recruitment of AXIN to the membrane (R-HSA-4641262)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Reactome
Disease
Reactome
Diseases of signal transduction
Reactome
Negative regulation of TCF-dependent signaling by WNT ligand antagonists
Reactome
RNF mutants show enhanced WNT signaling and proliferation
Name
Explore in Pharos
Explore in Source
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Disease
Diseases of signal transduction
Negative regulation of TCF-dependent signaling by WNT ligand antagonists
RNF mutants show enhanced WNT signaling and proliferation
Gene Ontology Terms (75)
Items per page:
10
1 – 10 of 12
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
MGI
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Mutant Phenotype (IMP)
BHF-UCL
Inferred from Mutant Phenotype (IMP)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (186)
1 – 10 of 186
SOST
Tclin
Novelty: 0.0009273
p_int: 0.999955988
p_ni: 0.000044012
Score: 0.991
Data Source: BioPlex,Reactome,STRINGDB
TGIF2LY
Tdark
Family: TF
p_int: 0.999944524
p_ni: 0.000055476
Data Source: BioPlex
DKK1
Tchem
Novelty: 0.00117121
p_int: 0.999914749
p_ni: 0.000085251
Score: 0.998
Data Source: BioPlex,Reactome,STRINGDB
RASD2
Tbio
Family: Enzyme
Novelty: 0.00490468
p_int: 0.999438072
p_ni: 0.000561928
Score: 0.209
Data Source: BioPlex,STRINGDB
POMK
Tbio
Family: Kinase
Novelty: 0.09340344
p_int: 0.999273004
p_ni: 0.000726996
Data Source: BioPlex
GPATCH2
Tdark
Novelty: 0.03284393
p_int: 0.997534825
p_ni: 0.002465175
Data Source: BioPlex
PARP16
Tbio
Family: Enzyme
Novelty: 0.09651799
p_int: 0.997033402
p_ni: 0.002966598
Data Source: BioPlex
ETV6
Tbio
Family: TF
Novelty: 0.00151718
p_int: 0.994126413
p_ni: 0.005873587
Score: 0.404
Data Source: BioPlex,STRINGDB
TAZ
Tbio
Novelty: 0.00372301
p_int: 0.991121004
p_ni: 0.008878996
Data Source: BioPlex
RASSF1
Tbio
Novelty: 0.00137149
p_int: 0.987425779
p_ni: 0.012574221
Data Source: BioPlex
Publication Statistics
PubMed Score  324.66

PubMed score by year
PubTator Score  273.94

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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