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Tbio
ITGA10
Integrin alpha-10

Protein Summary
Description
Integrin alpha-10/beta-1 is a receptor for collagen. Integrins are integral transmembrane glycoproteins composed of noncovalently linked alpha and beta chains. They participate in cell adhesion as well as cell-surface mediated signalling. This gene encodes an integrin alpha chain and is expressed at high levels in chondrocytes, where it is transcriptionally regulated by AP-2epsilon and Ets-1. The protein encoded by this gene binds to collagen. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000369304
  • ENSP00000358310
  • ENSG00000143127
  • ENST00000539363
  • ENSP00000439894

Symbol
  • PRO827
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.64
cell line
0.61
protein domain
0.58
tissue
0.57
tissue sample
0.57


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.5   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 30   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.5   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 30   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
myeloid white cell count
1
1
1
70.8
apolipoprotein A 1 measurement
1
1
1
21.4
high density lipoprotein cholesterol measurement
1
1
1
20.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
myeloid white cell count
1
70.8
apolipoprotein A 1 measurement
1
21.4
high density lipoprotein cholesterol measurement
1
20.9
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
integrin subunit alpha 10
VGNC:6890
457982
Macaque
integrin subunit alpha 10
100428484
Mouse
MGI:2153482
213119
Rat
RGD:1305152
310683
Dog
integrin subunit alpha 10
VGNC:42121
608287
Species
Name
OMA
EggNOG
Inparanoid
Chimp
integrin subunit alpha 10
Macaque
integrin subunit alpha 10
Mouse
Rat
Dog
integrin subunit alpha 10
Pathways (28)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
CHL1 interactions
Reactome
Developmental Biology
Reactome
Extracellular matrix organization
Reactome
Hemostasis
Name
Explore in Pharos
Explore in Source
Axon guidance
CHL1 interactions
Developmental Biology
Extracellular matrix organization
Hemostasis
Protein-Protein Interactions (100)
1 – 10 of 100
ITGB1
Tclin
Novelty: 0.00055626
Score: 0.975
Data Source: Reactome,STRINGDB
ITGB8
Tbio
Novelty: 0.01564348
Score: 0.97
Data Source: STRINGDB
ITGB5
Tbio
Novelty: 0.01455909
Score: 0.967
Data Source: STRINGDB
ITGB7
Tclin
Novelty: 0.01290005
Score: 0.962
Data Source: STRINGDB
ITGB3
Tclin
Novelty: 0.00067255
Score: 0.96
Data Source: STRINGDB
ITGB2
Tclin
Novelty: 0.00185859
Score: 0.954
Data Source: STRINGDB
ITGB6
Tbio
Novelty: 0.01118242
Score: 0.94
Data Source: STRINGDB
COL2A1
Tbio
Novelty: 0.0011102
Score: 0.925
Data Source: STRINGDB
ITGA8
Tbio
Novelty: 0.0220023
Score: 0.923
Data Source: STRINGDB
ITGAV
Tchem
Novelty: 0.00148589
Score: 0.919
Data Source: STRINGDB
Publication Statistics
PubMed Score  27.50

PubMed score by year
PubTator Score  12.4

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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