Tbio ITGA10 Integrin alpha-10

Protein Summary

Description

Integrin alpha-10/beta-1 is a receptor for collagen. Integrins are integral transmembrane glycoproteins composed of noncovalently linked alpha and beta chains. They participate in cell adhesion as well as cell-surface mediated signalling. This gene encodes an integrin alpha chain and is expressed at high levels in chondrocytes, where it is transcriptionally regulated by AP-2epsilon and Ets-1. The protein encoded by this gene binds to collagen. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]

Uniprot Accession IDs

• O75578
• B2RAM4
• B2RTV5
• Q6UXJ6
• Q9UHZ8

Gene Name

• ITGA10

Ensembl ID

• ENST00000369304
• ENSP00000358310
• ENSG00000143127
• ENST00000539363
• ENSP00000439894

Symbol

• PRO827

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
microRNA	0.64
cell line	0.61
protein domain	0.58
tissue	0.57
tissue sample	0.57

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.17   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 30   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.17   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 30   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0