Tbio CRCP DNA-directed RNA polymerase III subunit RPC9

Protein Summary

Description

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity). Accessory protein for the calcitonin gene-related peptide (CGRP) receptor. It modulates CGRP responsiveness in a variety of tissues. This gene encodes a membrane protein that functions as part of a receptor complex for a small neuropeptide that increases intracellular cAMP levels. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O75575
• A8MUZ4
• A8MW23
• B2R4H4
• B4E198
• Q3KRA3
• Q5HYF1
• Q8IXL4
• RNA polymerase III subunit C9

Gene Name

• CRCP

Ensembl ID

• ENST00000338592
• ENSP00000340044
• ENSG00000241258
• ENST00000395326
• ENSP00000378736
• ENST00000398684
• ENSP00000381674
• ENST00000431089
• ENSP00000388653

Symbol

• RCP
• RCP9
• RPC9
• CGRPRCP
• CGRP-RCP

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.93
molecular function	0.84
virus perturbation	0.79
cell type or tissue	0.76
transcription factor binding site profile	0.75

Protein Classes

PANTHER Classes

Protein / Receptor / G-protein Coupled Receptor / Dna-directed Rna Polymerase Iii Subunit Rpc9

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 133.44   (req: < 5)

Gene RIFs: 14   (req: <= 3)

Antibodies: 78   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 133.44   (req: >= 5)

Gene RIFs: 14   (req: > 3)

Antibodies: 78   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0