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Tbio
MTRF1
Peptide chain release factor 1, mitochondrial

Protein Summary
Description
Mitochondrial peptide chain release factor that directs the termination of translation in response to the peptide chain non-cognate termination stop codons AGG and AGA. The protein encoded by this gene was determined by in silico methods to be a mitochondrial protein with similarity to the peptide chain release factors (RFs) discovered in bacteria and yeast. The peptide chain release factors direct the termination of translation in response to the peptide chain termination codons. Initially thought to have a role in the termination of mitochondria protein synthesis, a recent publication found no mitochondrial translation release functionality. Multiple alternatively spliced transcript variants have been suggested by mRNA and EST data; however, their full-length natures are not clear. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000379477
  • ENSP00000368790
  • ENSG00000120662
  • ENST00000379480
  • ENSP00000368793

Symbol
  • RF1
  • MRF1
  • MTTRF1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.92
cell type or tissue
0.71
kinase perturbation
0.71
tissue sample
0.6
interacting protein
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.33   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 124   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.33   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 124   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (150)
1 – 10 of 150
MTMR2
Tbio
Family:  Enzyme
Novelty:  0.01403122
p_int:  0.999998681
p_ni:  0.000001316
p_wrong:  3e-9
Data Source:  BioPlex
PALB2
Tbio
Novelty:  0.00320056
p_int:  0.999998396
p_ni:  0.000001588
p_wrong:  1.5e-8
Data Source:  BioPlex
ACTA1
Tbio
Novelty:  0.00111813
p_int:  0.999967655
p_ni:  0.000032345
Data Source:  BioPlex
ATF7IP
Tbio
Novelty:  0.04269323
p_int:  0.999957454
p_ni:  0.000042544
p_wrong:  1e-9
Data Source:  BioPlex
TYW3
Tdark
Novelty:  0.15183348
p_int:  0.999938974
p_ni:  0.000060971
p_wrong:  5.4e-8
Data Source:  BioPlex
ASB7
Tdark
Novelty:  0.21883348
p_int:  0.999879622
p_ni:  0.000120377
p_wrong:  2e-9
Data Source:  BioPlex
XRCC4
Tbio
Novelty:  0.00305644
p_int:  0.999427273
p_ni:  0.000572196
p_wrong:  5.31e-7
Data Source:  BioPlex
CADM4
Tbio
Novelty:  0.05034541
p_int:  0.998644406
p_ni:  0.001355082
p_wrong:  5.12e-7
Data Source:  BioPlex
DBT
Tbio
Family:  Enzyme
Novelty:  0.0070589
p_int:  0.995717118
p_ni:  0.004282882
Data Source:  BioPlex
VAMP3
Tbio
Novelty:  0.00694332
p_int:  0.944628035
p_ni:  0.053086503
p_wrong:  0.002285462
Data Source:  BioPlex
Gene Ontology Terms (5)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intraocular pressure measurement
1
1
1
21.5
systolic blood pressure
1
1
1
12.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intraocular pressure measurement
1
21.5
systolic blood pressure
1
12.7
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mitochondrial translation release factor 1
VGNC:14518
452558
Mouse
MGI:2384815
211253
Rat
RGD:1584329
686234
Dog
mitochondrial translation release factor 1
VGNC:43492
485465
Horse
mitochondrial translation release factor 1
VGNC:20436
100051407
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mitochondrial translation release factor 1
Mouse
Rat
Dog
mitochondrial translation release factor 1
Horse
mitochondrial translation release factor 1
Publication Statistics
PubMed Score 9.33
PubMed score by year
PubTator Score 118.74
PubTator score by year